A5071205078- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Cardiovascular Syncope and Autonomic Disorders
- Acute Ischemic Stroke Management
- Lymphatic System and Diseases
- Family Caregiving in Mental Illness
- Schizophrenia research and treatment
- Hip and Femur Fractures
- Nutrition and Health in Aging
- Child and Adolescent Psychosocial and Emotional Development
- Cardiovascular Function and Risk Factors
- Adolescent and Pediatric Healthcare
- Frailty in Older Adults
- Neurological Disorders and Treatments
- Mental Health Treatment and Access
- Effects of Vibration on Health
- Antioxidant Activity and Oxidative Stress
- Body Composition Measurement Techniques
- Bipolar Disorder and Treatment
University Hospitals Sussex NHS Foundation Trust
2019-2023
University College London
2019
University College Hospital
2019
University of Birmingham
2014-2016
Queen Elizabeth Hospital Birmingham
2016
NIHR Surgical Reconstruction and Microbiology Research Centre
2014
Abstract Lymphangiogenesis associated with tertiary lymphoid structure (TLS) has been reported in numerous studies. However, the kinetics and dynamic changes occurring to lymphatic vascular network during TLS development have not studied. Using a viral-induced, resolving model of formation salivary glands adult mice we demonstrate that expansion is tightly regulated. Lymphatic vessel occurs two distinct phases. The first wave dependent on IL-7. second phase, responsible for leukocyte exit...
Carer burden is high during First Episode Psychosis (FEP) and evidence suggests that this a predictor of poor long-term outcome. However our understanding factors associated with higher poor. We propose carers' cultural backgrounds health belief models will influence their perceived care, over above explained by severity illness.Patients FEP primary Carers were recruited from the Early Intervention Service. Patients completed range validated measures, self-report ethnicity demographic...
Childhood abuse is a risk factor for poorer illness course in bipolar disorder, but the reasons why are unclear. Trait-like features such as affective instability and impulsivity could be part of explanation. We aimed to examine whether childhood was associated with clinical associations were mediated by or impulsivity.We analysed data from 923 people I disorder recruited Bipolar Disorder Research Network. Adjusted between abuse, eight variables analysed. A path analysis examined direct...
Objectives: The risk profile of white-coat hypertension/effect (WCH/E) remains unclear. This study aimed to investigate the relationship between WCH/E, markers cardiovascular and cerebrovascular events. Methods: is a sub-group analysis Arterial Stiffness In lacunar Stroke Transient ischemic attack (ASIST) study, which recruited 96 patients aged at least 40 years old with diagnosis transient or stroke in preceding 14 days. Thirty-two target blood pressure (clinic <140/90 mmHg daytime...
Sarcopenia is associated with poor outcomes, and evidence suggests an inverse relationship between skeletal muscle mass cardiovascular risk. has been studied after stroke, but its value as a risk factor for stroke not examined. This prospective cohort study measured sarcopenia in stroke/TIA patients at baseline to explore role predicting recurrent events.The Arterial Stiffness In lacunar Stroke TIA (ASIST) included 96 TIA/lacunar of which 82 (mean age 71.2±10.8 years) had bioimpedance...
Objective: Small vessel disease, as measured by white matter hyperintensity (WMH) in the brain, is known to be associated with increased stroke risk and cognitive impairment. This study explored relationship between WMH on computerised tomography (CT) coat hypertension/effect (WCH/E) patients recent transient ischaemic attack (TIA) or lacunar (LS). Design method: Ninety-six recruited for ASIST trial (Arterial Stiffness Lacunar Stroke TIA) underwent measurement of clinic blood pressure (BP)...
Introduction: Hip fractures cause significant morbidity and mortality in the elderly population. There are over 75′000 per year UK. Despite this, there has been little research on patients' views experiences of hip fractures. This was highlighted as an area where further required NICE guidelines for The aim this study to assess their fracture management. Sampling methods: An interview script created based recommendations made guidance. Approval gained from local patient experience team. A 30...
Objective: International guidelines advocate conservative management of post-stroke white coat hypertension. The aims this study were; i) does WCH/E result in increased stroke risk? and ii) is associated with surrogate markers cardiovascular Design method: Arterial Stiffness In Lacunar Stroke TIA (ASIST) recruited 96 patients, age >40-year-old, a confirmed diagnosis transient ischaemic attack (TIA) or lacunar the preceding 14 days. Patients were grouped by BP phenotypes. Thirty-four patients...
Abstract Objective White coat hypertension/effect (WCH/E) describes an elevated clinic blood pressure (BP) with normal daytime ambulatory BP (ABPM) values. It is not clear whether WCH/E associated adverse vascular risk. This study aimed to determine the relationship between and arterial stiffness in a cohort of patients who had transient ischaemic attack (TIA) or lacunar stroke (LS). Design Method The Arterial Stiffness In Lacunar Stroke TIA (ASIST) recruited 96 patients, aged over 40 years...
Objective: White coat hypertension/effect (WCH/E) describes an elevated clinic blood pressure (BP) with normal daytime ambulatory BP (ABPM) values. It is not clear whether WCH/E associated adverse vascular risk. This study aimed to determine the relationship between and arterial stiffness in a cohort of patients who had transient ischaemic attack (TIA) or lacunar stroke (LS). Design method: The Arterial Stiffness In Lacunar Stroke TIA (ASIST) recruited 96 patients, age >40-years-old,...
Abstract Objective International guidelines advocate conservative management of post-stroke white coat hypertension. The aims this study were to investigate; i) does WCH/E result in increased stroke risk? and ii) is associated with surrogate markers cardiovascular Methods Arterial Stiffness In Lacunar Stroke TIA (ASIST) recruited 96 patients, aged over 40 years old, a confirmed diagnosis transient ischaemic attack (TIA) or lacunar the preceding 14 days. Patients grouped by BP phenotypes....