Patients who have experienced a first cerebral ischemic event are at increased risk of recurrent stroke. There is strong evidence that low-level inflammation as measured by high sensitivity C-reactive protein (hs-CRP) predictor further events. Other mechanisms implicated in the pathogenesis stroke may play role determining secondary events, including oxidative stress and adaptive response to it activation neuroprotective pathways hypoxia, for instance through induction erythropoietin (EPO)....

To investigate the correlation between sarcopenia and arterial stiffness in Caucasians, centering on relationship skeletal mass index (SMI) cardio-ankle vascular (CAVI) to assess use of CAVI predicting sarcopenia.United Kingdom.UK adults aged 45 years over (N = 366, n 177 male, 189 female).Bioimpedance analysis was used derive SMI. score calculated using a screening system. Handgrip strength measured standard dynamometer.Average significantly correlated with SMI (correlation coefficient (r)...

Objectives: The risk profile of white-coat hypertension/effect (WCH/E) remains unclear. This study aimed to investigate the relationship between WCH/E, markers cardiovascular and cerebrovascular events. Methods: is a sub-group analysis Arterial Stiffness In lacunar Stroke Transient ischemic attack (ASIST) study, which recruited 96 patients aged at least 40 years old with diagnosis transient or stroke in preceding 14 days. Thirty-two target blood pressure (clinic <140/90 mmHg daytime...

A young woman with systemic lupus erythematosus (SLE) developed recurrent enterovirus meningoencephalitis while taking prednisolone, azathioprine and rituximab. After reducing the immunosuppression, she a central nervous system (CNS) flare of SLE, still present in cerebrospinal fluid (CSF). There are no evidence-based specific treatments for encephalitis, but responded well to intravenous immunoglobulin alongside pulsed methylprednisolone This case highlights difficulties managing people...

Sarcopenia is associated with poor outcomes, and evidence suggests an inverse relationship between skeletal muscle mass cardiovascular risk. has been studied after stroke, but its value as a risk factor for stroke not examined. This prospective cohort study measured sarcopenia in stroke/TIA patients at baseline to explore role predicting recurrent events.The Arterial Stiffness In lacunar Stroke TIA (ASIST) included 96 TIA/lacunar of which 82 (mean age 71.2±10.8 years) had bioimpedance...

A 56-year-old man presented with evolving symptoms of left-sided weakness and fatigue over six months. Examination revealed spastic hemiparesis. MR brain imaging confluent, oedematous white matter lesions in the right hemisphere without restricted diffusion or enhancement. Initial CSF analysis was unremarkable, including negative JC virus. Blood screen a mild lymphopaenia. CT scanning viscera showed pulmonary changes which revealed, via transbronchial biopsy, non-caseating granulomata...

Objective: Small vessel disease, as measured by white matter hyperintensity (WMH) in the brain, is known to be associated with increased stroke risk and cognitive impairment. This study explored relationship between WMH on computerised tomography (CT) coat hypertension/effect (WCH/E) patients recent transient ischaemic attack (TIA) or lacunar (LS). Design method: Ninety-six recruited for ASIST trial (Arterial Stiffness Lacunar Stroke TIA) underwent measurement of clinic blood pressure (BP)...

Introduction Historically, single tissue vasculitis has been managed with steroid monotherapy. Recent data from large longitudinal databases on systemic suggest Non-Systemic Vasculitic Neuropathy (NSVN) higher rates of relapse, recommending that more aggressive immunotherapy is employed. Aim To investigate the relapse rate in NSVN response to Methods A retrospective case note review clinically and/or pathologically defined cases (Systemic Neuropathy) SVN and two London specialist peripheral...

Introduction: Transient Ischaemic Attacks (TIA) carry a significant risk of subsequent TIA and stroke. Identifying high patients who are likely to sustain another event is crucial. Arterial stiffness an independent predictor cardiovascular events including stroke, however its ability predict yet be investigated. Central aortic pressure emerging as rather than peripheral blood (BP). This study investigated the prevalence arterial BP characteristics in population have suffered TIA. Methods:...

Background: The ABCD2 score is a clinical tool currently categorising transient ischaemic attack (TIA) patients as low or high risk. Arterial stiffness, novel physiological parameter predicting future cardiovascular events, has not been explored in TIA populations. Methods: following arterial stiffness parameters were measured aged >40 years: carotid-femoral pulse wave velocity (C-F PWV), carotid-radial (C-R PWV) using Complior® and central peripheral blood pressure (BP) Arteriograph®....

Natalizumab is an established treatment for highly active Relapsing-Remitting Multiple Sclerosis (RRMS). Two-year efficacy in the AFFIRM trial showed No Evidence of Disease Activity(NEDA) – no relapses, disability progression, new MRI lesions 37% patients compared with 7% placebo group. NEDA increasingly used as a goal RRMS. Methodology We performed retrospective analysis RRMS our centre. assessed proportion achieving typical clinical setting at least 1 year duration and analysed predictors...

We report a 52-year old female who initially presented with episodes of vertigo, headache and diplopia. Vestibular migraine or Meniere9s disease was diagnosed. Two-years later she reported sensory symptoms in her upper limbs. Normal investigations led to functional diagnosis being considered. However worsened an acute-onset sensorineural hearing loss Examination revealed evidence brainstem signs ataxia. MRI showed enhancing right dorsal pontine lesion, CSF normal. She diagnosed primary CNS...

<h3>Background</h3> Idiopathic intracranial hypertension (IIH) is classically diagnosed in overweight, adolescent females and consists of secondary visual symptoms signs usually, but not exclusively, the context headache. Relationships between CSF opening pressure clinical features are straightforward, however, as recent IIH treatment trial has shown. <h3>Methods</h3> patients with pressures above 50 cm (“extreme IH”) were identified from first 100 referrals to our Neuro-Ophthalmology...

<h3></h3> Idiopathic Parkinson's disease (IPD) is more common in men than women, with a relative risk 1.5 times greater males[1]. Additionally, IPD tends to present later women [2, 3] and progress slowly, as females are likely the tremor-dominant PD phenotype[2]. Attempts have been made establish if female gonadal hormones explain these observed differences, exerting neuro-protective effect on dopaminergic transmission neuronal degeneration, however results inconsistent [4]. There shared...

Objective: Sarcopenia, the loss of lean mass and increase in fat with age, is associated increased cardiovascular risk. Sarcopenic muscle atrophy has been correlated arterial stiffness (measured via brachial-ankle pulse wave velocity) large-scale studies predominately Asian patients. Our study investigated correlation between sarcopenia Caucasians, centring on relationship skeletal index (SMI) cardio-ankle vascular (CAVI), to assess use CAVI predicting sarcopenia. Design method: 366 UK...

Objective: International guidelines advocate conservative management of post-stroke white coat hypertension. The aims this study were; i) does WCH/E result in increased stroke risk? and ii) is associated with surrogate markers cardiovascular Design method: Arterial Stiffness In Lacunar Stroke TIA (ASIST) recruited 96 patients, age >40-year-old, a confirmed diagnosis transient ischaemic attack (TIA) or lacunar the preceding 14 days. Patients were grouped by BP phenotypes. Thirty-four patients...

Abstract Objective White coat hypertension/effect (WCH/E) describes an elevated clinic blood pressure (BP) with normal daytime ambulatory BP (ABPM) values. It is not clear whether WCH/E associated adverse vascular risk. This study aimed to determine the relationship between and arterial stiffness in a cohort of patients who had transient ischaemic attack (TIA) or lacunar stroke (LS). Design Method The Arterial Stiffness In Lacunar Stroke TIA (ASIST) recruited 96 patients, aged over 40 years...

A previous evaluation of concomitant nerve and muscle biopsy in the Centre for Neuromuscular Diseases, NHNN suggested that addition (vastus lateralis) to (sural) tissue examination did not improve diagnostic yield suspected vasculitis. Here we assess it may be beneficial other circumstances. We reviewed from combined biopsies performed between 2013 2018. Basic demographic, clinical histological information was collected retrospectively complete list locally during study period. 230 49 were...

Objective: White coat hypertension/effect (WCH/E) describes an elevated clinic blood pressure (BP) with normal daytime ambulatory BP (ABPM) values. It is not clear whether WCH/E associated adverse vascular risk. This study aimed to determine the relationship between and arterial stiffness in a cohort of patients who had transient ischaemic attack (TIA) or lacunar stroke (LS). Design method: The Arterial Stiffness In Lacunar Stroke TIA (ASIST) recruited 96 patients, age >40-years-old,...