A5001234998- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Cancer-related gene regulation
- Abdominal Surgery and Complications
- Pelvic and Acetabular Injuries
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Hernia repair and management
- Cancer Mechanisms and Therapy
- Cell Adhesion Molecules Research
- Gastrointestinal Tumor Research and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Intestinal and Peritoneal Adhesions
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- Biopolymer Synthesis and Applications
- Peptidase Inhibition and Analysis
- Muscle and Compartmental Disorders
- Liver Disease and Transplantation
Shanghai Jiao Tong University
2015-2025
Shanghai Ninth People's Hospital
2016-2025
Ruijin Hospital
2022-2025
Guangxi Medical University
2025
Shanxi Datong University
2017-2019
Johns Hopkins Medicine
2019
Johns Hopkins University
2019
Shanghai First People's Hospital
2012-2017
XinHua Hospital
2017
Shanghai Third People's Hospital
2014
Abstract Background and Aims Remote ischaemic pre-conditioning (RIPC) delivered shortly prior to an angiographic procedure may reduce contrast-associated acute kidney injury (CA-AKI). Whether a longer interval between RIPC contrast administration also reduces CA-AKI post-procedural complications after coronary angiography (CAG) or percutaneous intervention (PCI) is unknown. Methods This was multicentre, randomized trial of patients at risk undergoing elective CAG PCI comparing delayed (four...
Metadherin (MTDH) is overexpressed in some malignancies and enhances drug resistance; however, its role gastric cancer (GC) the underlying mechanisms remain largely unexplored. Here, we explore mechanism by which MTDH induces resistance GC.We analysed level of GC adjacent normal mucosal tissues real-time quantitative PCR (q-PCR). We also autophagy western blot analysis, confocal microscopy, transmission electron microscopy after knockdown overexpression, examined fluorouracil (5-FU) Cell...
Growing tumors alter their metabolic profiles to support the increased cell proliferation. SETD1A, a histone lysine methyltransferase which specifically methylates H3K4, plays important roles in both normal and cancer functions. However, function of SETD1A gastric (GC) progression its role GC reprogramming are still largely unknown. In current study, we discovered that expression was higher tumor specimens compared surrounding nontumor tissues. Upregulation proliferation, whereas...
Mesenchymal stem cells (MSC) are potent in immunomodulation. It has been proven that MSC functioned to correct immune disorder several diseases. Here, we tested the hypothesis from human bone marrow (hMSC) can provide a potential therapy for experimental autoimmune myasthenia gravis (EAMG). EAMG mice model was established by subcutaneous injection of synthetic analogue acetylcholine receptor (AchR), then, hMSC were intravenously delivered into these repeatedly. The results showed could...
Contactin-1 (CNTN-1) has been shown to promote cancer metastasis. Previously, we have reported that the expression of CNTN-1 was upregulated in gastric tissues compared with adjacent normal tissues. Here, investigated significance and its underlying mechanism metastasis mediated by epithelial-mesenchymal transition (EMT) cancer.The expressions EMT-related proteins were assayed through immunohistochemical staining pathological specimens from patients cancer. Other methods including reverse...
Abstract Background To investigate on the expressions and clinical significances of hepatocyte growth factor receptor (c-MET), phosphorylated c-MET (p-MET) e2f-1 transcription in primary lesion gastric adenocarcinoma (GC). Method Tissue samples from GC patients who accepted D 2 /D 3 radical gastrectomy with R 0 /R 1 resection were stained by immunohistochemistry c-MET, p-MET, Ki-67. The univariate multivariate analyses involving clinicopathological parameters prognostic factors evaluated....
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
ABSTRACT Background and Aims Lymphangiogenesis is enhanced during the development of liver cirrhosis portal hypertension (PHT). However, hepatic lymphatic vascular system understudied in PHT. Hydrogen sulfide (H 2 S) related compounds have potential prolymphangiogenic effects besides its previously reported vascular‐protective effects. Therefore, we aimed to investigate endogenous H S donor S‐allyl‐cysteine (SAC) on bile duct ligation (BDL)‐induced Methods BDL rats with cholestatic PHT were...
ABSTRACT Introduction Blood stasis syndrome (BSS) is one of the common syndromes in traditional Chinese medicine. The medicine compound composed “Danggui‐Guizhi (DG‐GZ)”as core has effect reducing blood and promoting circulation. However, difference efficacy DG‐GZ decoction dispensing granules are still unclear. Objective Investigation Danggui (DG) Guizhi (GZ) an animal study (Six groups, n = 6). Methodology All rats were randomly divided into six groups: control, model, Danggui—Guizhi...
<title>Abstract</title> <bold>Purpose: </bold>To compare the clinical effect of ruiyun procedure for hemorrhoids (RPH) and prolapse (PPH) treatment mixed with grade Ⅱ-Ⅳ. <bold>Methods: </bold>Total 192 patients Ⅱ-Ⅳ were retrospectively reviewed in Ninth People’s Hospital (North) Affiliated to Shanghai Jiao Tong University School Medicine, 80 cases assigned RPH group, 112 PPH group. The primary efficacy outcome was rate curative at 3 month after operation, 1-year recurrence rate. Secondary...
Abstract Background To study on expressions and clinical significances of CD133 protein mRNA in primary lesion gastric adenocarcinoma (GC). Methods Expressions by immunostaining (99 cases) semi-quantitative RT-PCR (31 were detected noncancerous mucosa tissue (NCGT). Correlations expression with clinicopathological parameters post-operative survival analyzed. Relations level Ki-67 labeling index (LI), lymphatic metastasis assessed too. Results Brown particles indicating positivity occurred...
Background . This study aimed at determining the relationship between vascular endothelial growth factor-C (VEGF-C), factor receptor-3 (VEGFR-3), and contactin-1 (CNTN-1) expression in gastric cancer (GC). Methods The level of CNTN-1 mRNA protein 33 cases was determined using RT-PCR Western Blot. And 105 were immunohistochemically examined for VEGF-C, VEGFR-3, expressions. Assessment lymphatic vessel density (LVD) also performed by D2-40 immunostaining. Then we analyzed relationships CNTN-1,...
Abstract Background In this study, we aimed to identify independent predictive factors for lymph node metastasis (LNM) in T1 colon cancer. Methods Data of 8056 eligible patients were retrospectively collected from the Surveillance, Epidemiology, and End Results (SEER) database during 2004–2012. We performed logistic regression analysis LNM. Both unadjusted adjusted Cox analyses used determine association between LNM patient survival. Finally, competing risks cumulative incidence function...
N6-methyladenosine (m6A) RNA modification plays a critical role in gastric cancer (GC). However, the relationship between m6A "eraser", FTO, and ALKBH5, prognosis of GC still remains unclear. This study aimed to evaluate effect FTO ALKBH5 on patients their potential roles GC.A total 738 samples with clinical information obtained from two independent datasets were included divided into training set testing set. Differential expression analysis "eraser" related genes was performed. The LASSO...
This study investigated the effect of complete reduction and transection hernia sac during laparoscopic indirect inguinal repair on seroma.Retrospective analysis was performed 1763 cases undergoing in three centers from January 2017 to September 2019, among them, 311 patients with 1452 sac, data two groups were tested by t-test. Logistic univariate 233 postoperative seroma, variables p < 0.05 included for multivariate analysis. Then, group matched 1:1 propensity score matching, caliper value...
Aberrant epigenetic modification induces oncogene expression and promotes cancer development. The histone lysine methyltransferase SETD1A, which specifically methylates 3 4 (H3K4), is involved in tumor growth metastasis, its ectopic has been detected aggressive malignancies. Our previous study reported that SETD1A gastric (GC) proliferation tumorigenesis. However, the function molecular mechanisms of GC metastasis remain to be elucidated. In this study, we found overexpression promoted...