A5110226440- Acute Kidney Injury Research
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Cardiac Imaging and Diagnostics
- Dialysis and Renal Disease Management
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Acute Ischemic Stroke Management
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Phagocytosis and Immune Regulation
- Natural product bioactivities and synthesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gout, Hyperuricemia, Uric Acid
Nanjing Medical University
2019-2025
First Affiliated Hospital of Anhui Medical University
2015-2025
Anhui Medical University
2015-2025
Bengbu Medical College
2019-2025
Shenzhen Pingle Orthopedic Hospital
2022-2024
Guangzhou University of Chinese Medicine
2022-2024
Macau University of Science and Technology
2024
Zhengzhou University
2022
Ferroptosis is a newly identified form of non-apoptotic programmed cell death, characterized by the iron-dependent accumulation lethal lipid reactive oxygen species (ROS) and peroxidation membrane polyunsaturated fatty acid phospholipids (PUFA-PLs). unique among other death modalities in many aspects. It initiated excessive oxidative damage due to iron overload compromised antioxidant defense systems, including system Xc-/ glutathione (GSH)/glutathione peroxidase 4 (GPX4) pathway...
Acute kidney injury (AKI) is a clinical syndrome associated with multitude of conditions. Although renal replacement therapy (RRT) remains the cornerstone treatment for advanced AKI, its implementation can potentially pose risks and may not be readily accessible across all healthcare settings regions. Elevated lactate levels are implicated in sepsis-induced AKI; however, it unclear whether increased directly induces AKI or elucidates underlying mechanisms. For human, measurement arterial...
Hepatocellular carcinoma (HCC) is a lethal malignancy. Although considerable efforts have been made in recent years regarding treatments, effective therapeutic drugs for HCC remain insufficient. In the present study, polyphyllin VI was identified as potential drug by screening natural herbal compounds. The effects of were assessed using Cell Counting Kit‑8, lactate dehydrogenase release and colony formation assays. occurrence ferroptosis determined assessing lipid peroxidation reactive...
Abstract Background and Aims Remote ischaemic pre-conditioning (RIPC) delivered shortly prior to an angiographic procedure may reduce contrast-associated acute kidney injury (CA-AKI). Whether a longer interval between RIPC contrast administration also reduces CA-AKI post-procedural complications after coronary angiography (CAG) or percutaneous intervention (PCI) is unknown. Methods This was multicentre, randomized trial of patients at risk undergoing elective CAG PCI comparing delayed (four...
Liver cancer is a highly lethal malignancy. Despite considerable efforts made in recent years, the prognosis of patients with liver remains poor. Curcuma zedoaria (known as Ezhu Chinese) widely prescribed traditional Chinese medicine. Germacrone (GM) sesquiterpene constituent derived from essential oil Ezhu, and exerts anti-carcinogenic effects by inducing apoptosis various cells. The present study investigated potential mechanism GM HepG2 Cell Counting Kit-8, colony-formation lactate...
The significance of uric acid (UA) and high-density lipoprotein cholesterol (HDL-C) in the prognosis acute myocardial infarction (AMI) remains controversial. This study investigated effect interaction between UA HDL-C on patients with AMI.In total, 480 AMI were included this study. Baseline follow-up data collected, primary endpoint was major adverse cardiovascular events (MACE). secondary all-cause death. Both additive multiplicative interactions calculated to evaluate their prognosis....
<b><i>Introduction:</i></b> As disorder of tryptophan metabolism is common in CKD, the rate-limiting enzyme tryptophan, indoleamine-2,3-dioxygenase (IDO), has been reported to be involved while accurate mechanism remains unknown. This study was designed explore correlations between IDO and kidney fibrosis after ischemia-reperfusion injury (IRI). <b><i>Methods:</i></b> Wild-type (WT) mice knockout (IDO<sup>−/−</sup>) were divided...
Acute liver injury (ALI) is an acute inflammatory disease with a high mortality rate. Alternatively, activated macrophages (AAMs) have been linked to the inflammation and recovery of ALI. However, mechanism underlying AAM death in ALI has not studied sufficiently. We used liensinine (Lie) as drug choice after screening library small-molecule monomers 1488 compounds from traditional Chinese remedies. In ALI, we evaluated potential therapeutic effects mechanisms action found that it...
Some studies indicated that histone modification may be involved in depression disorder (DD). The maintenance of the acetylation state is work acetyltransferase (HAT) and deacetylase (HDAC), which thought to a potential diagnostic biomarker depression. However, it still unknown how acetylation-related genes (HAC-RGs) contribute onset progression DD. GSE76826 GSE98793were obtained from Gene Expression Omnibus (GEO) database, HAC-RGs were acquired GeneCards database. Initially, differentially...
Atherosclerosis (AS)‑related coronary artery disease is the main cause of morbidity and mortality around globe. Eburicoic acid, a triterpenoid compound from Antrodia camphorata, exerts anti‑inflammatory anti‑hyperlipidemic effects, although its role in atherogenesis remains unknown. Endothelial cell pyroptosis‑caused chronic inflammatory response within vessel walls critical initial event atherogenesis, making it promising target to prevent AS. The present study was designed investigate...
Abstract Objective Long non-coding RNAs (lncRNAs) play critically in the pathogenesis of myocardial ischemia–reperfusion (I/R) injury. Thus, it was proposed to investigate mechanism LINC00461 disease through mediating microRNA-185-3p (miR-185-3p)/myeloid differentiation primary response gene 88 (Myd88) axis. Methods miR-185-3p, and Myd88 expression mice with I/R injury measured. Mice were injected expression-modified vectors, after which cardiac function, hemodynamics, enzyme, oxidative...
Abstract Background In patients undergoing percutaneous coronary intervention (PCI), contrast-induced acute kidney injury (CIAKI) is a frequent complication, especially in diabetics, and connected with severe mortality morbidity the short long term. Therefore, we aimed to develop CIAKI predictive model for diabetic patients. Methods 3514 diabetes from four hospitals were separated into three cohorts: training, internal validation, external validation. We developed six machine learning (ML)...
Abstract Aims Long non‐coding RNA HOXA11‐AS participated in heart disease. In this study, we aim to evaluate the potential roles of atherosclerosis and its underlying mechanisms. Methods results The expression levels ox‐LDL‐treated HUVECs arch tissues high‐fat diet‐fed ApoE −/− mice ( n = 10) were assessed by qRT‐PCR. effects knockdown on development evaluated using vitro vivo models. Luciferase reporter immunoprecipitation (RIP) assays verified relationships between or ROCK1 miR‐515‐5p....
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and characterized by insidious onset, rapid progression, poor prognosis. Immunotherapy a first-line treatment for advanced HCC. The identification immune-related prognostic markers may be an effective strategy to predict improve clinical response rate immunotherapy. DESeq2, edgeR, limma R packages were used compare transcriptomes HCC with different prognoses. Cancer-related databases such as UALCAN,...