Tingting Fan

ORCID: 0009-0005-5548-4174
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About
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Research Areas
  • Advanced Photocatalysis Techniques
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Heavy metals in environment
  • Lanthanide and Transition Metal Complexes
  • Fungal Biology and Applications
  • Covalent Organic Framework Applications
  • CRISPR and Genetic Engineering
  • Laser-Matter Interactions and Applications
  • Viral Infections and Immunology Research
  • RNA and protein synthesis mechanisms
  • CO2 Reduction Techniques and Catalysts
  • Metal-Organic Frameworks: Synthesis and Applications
  • Advanced Fiber Laser Technologies
  • Gas Sensing Nanomaterials and Sensors
  • Crystallography and molecular interactions
  • Plant Virus Research Studies
  • Clay minerals and soil interactions
  • Radioactive element chemistry and processing
  • Perovskite Materials and Applications
  • Arsenic contamination and mitigation
  • Adsorption and biosorption for pollutant removal
  • Silymarin and Mushroom Poisoning
  • RNA modifications and cancer
  • RNA regulation and disease

Gansu Agricultural University
2024-2025

Henan Normal University
2024-2025

Hefei University of Technology
2025

Ministry of Ecology and Environment
2019-2024

Xiamen University
2016-2024

University of Electronic Science and Technology of China
2020-2024

Ministry of Agriculture and Rural Affairs
2022-2024

Nationwide Children's Hospital
2024

Hebei University
2022-2024

Xi'an Jiaotong University
2022-2024

We demonstrate, to our knowledge, the first bright circularly polarized high-harmonic beams in soft X-ray region of electromagnetic spectrum, and use them implement magnetic circular dichroism measurements a tabletop-scale setup. Using counterrotating laser fields at 1.3 0.79 µm, we generate harmonics with photon energies exceeding 160 eV. The harmonic spectra emerge as sequence closely spaced pairs left right peaks, determined by conservation energy spin angular momentum. explain...

10.1073/pnas.1519666112 article EN Proceedings of the National Academy of Sciences 2015-11-03

Abstract Electrochemical carbon dioxide reduction reaction (CO 2 RR) using clean electric energy provides a sustainable route to generate highly‐valuable chemicals and fuels, which is beneficial for realizing the carbon‐neutral cycle. Up now, achieving narrow product distribution highly targeted selectivity over Cu‐based electrocatalysts still big challenge. Herein, sulfur modification on different crystal planes of cuprous oxide (Cu O) demonstrated, results in an improvement formate...

10.1002/adfm.202213145 article EN Advanced Functional Materials 2023-01-25

A novel hydrothermal-conjugate-copolymerization strategy has been developed for the preparation of a carbon-rich g-C<sub>3</sub>N<sub>4</sub> photocatalyst.

10.1039/c8ta03303j article EN Journal of Materials Chemistry A 2018-01-01

Abstract Cytosine base editors (CBEs) and adenine (ABEs) enable precise C-to-T A-to-G edits. Recently, ABE8e, derived from TadA-8e, enhances edits in mammalian cells plants. Interestingly, TadA-8e can also be evolved to confer editing. This study compares engineered CBEs rice tomato cells, identifying TadCBEa, TadCBEd, TadCBEd_V106W as efficient with high purity a narrow editing window. A dual editor, TadDE, promotes simultaneous Multiplexed TadCBEa TadDE is demonstrated transgenic rice, no...

10.1038/s41467-024-49473-w article EN cc-by Nature Communications 2024-06-14

Summary CRISPR‐Cas9 is widely used for genome editing, but its PAM sequence requirements limit efficiency. In this study, we explore Faecalibaculum rodentium Cas9 (FrCas9) plant especially in rice. FrCas9 recognizes a concise 5′‐NNTA‐3′ PAM, targeting more abundant palindromic TA sites genomes than the 5′‐NGG‐3′ of most popular SpCas9. shows cleavage activities at all tested with editing outcomes sharing same characteristics typical system. induces high‐efficiency targeted mutagenesis stable...

10.1111/pbi.14363 article EN cc-by-nc Plant Biotechnology Journal 2024-05-07

The CPA gene family regulates ionic balance and pH homeostasis in cells, significantly contributing to plant stress tolerance. In this study, a total of 63 BrCPA members were identified the whole genome Brassica rapa L. (B. rapa), three subfamily BrNHX (9), BrKEA (15), BrCHX (39), respectively. encoded 303-1259 amino acids, with molecular weights range 32,860.39~139,884.73 kDa, distributed on 10 chromosomes, contained 17 conserved motifs, BraKEA, had same chromosomes contain motifs. BraKEA...

10.3390/ijms26073099 article EN International Journal of Molecular Sciences 2025-03-27

EV71 is the primary pathogenic cause of hand-foot-mouth disease (HFMD), but an effective antiviral drug currently unavailable. Rupintrivir, inhibitor against human rhinovirus (HRV), has potent activities EV71. We determined high-resolution crystal structures 3C(pro)/rupintrivir complex, showing that although rupintrivir interacts with 3C(pro) similarly to HRV 3C(pro), C terminus cannot accommodate leaving-group pockets 3C(pro). Our reveal possesses a surface-recessive S2' pocket not present...

10.1128/jvi.05107-11 article EN Journal of Virology 2011-08-04

As a precise genome editing technology, base is broadly used in both basic and applied plant research. Cytosine editors (CBEs) adenine (ABEs) represent the two commonly editor types that mediate C-to-T A-to-G transition changes at target sites, respectively. To date, no transversion have been described plants. Here, we assessed three C-to-G (CGBEs) for targeting sequences with SpCas9’s canonical NGG protospacer adjacent motifs (PAMs) as well PAM-less SpRY-based CGBEs relaxed PAM...

10.3389/fgeed.2021.756766 article EN cc-by Frontiers in Genome Editing 2021-09-15

Abstract Among CRISPR-Cas genome editing systems, Streptococcus pyogenes Cas9 (SpCas9), sourced from a human pathogen, is the most widely used. Here, through in silico data mining, we have established an efficient plant engineering system using CRISPR-Cas9 probiotic Lactobacillus rhamnosus . We confirmed predicted 5’-NGAAA-3’ PAM via bacterial depletion assay and showcased its exceptional efficiency rice, wheat, tomato, Larix cells, surpassing LbCas12a, SpCas9-NG, SpRY when targeting...

10.1038/s41467-023-41802-9 article EN cc-by Nature Communications 2023-09-29
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