A5027884111- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Pharmaceutical Practices and Patient Outcomes
- Smoking Behavior and Cessation
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Education and Critical Thinking Development
- Cholinesterase and Neurodegenerative Diseases
- Student Assessment and Feedback
- Interprofessional Education and Collaboration
- Evaluation of Teaching Practices
- Mast cells and histamine
- Research in Social Sciences
- Biochemical Analysis and Sensing Techniques
- Pharmaceutical Economics and Policy
- Attention Deficit Hyperactivity Disorder
- Malaria Research and Control
- Neuropeptides and Animal Physiology
- Educational Strategies and Epistemologies
- Neuroscience of respiration and sleep
- Parkinson's Disease Mechanisms and Treatments
Ministry of Social Affairs and Health
2024
International Drug Development
2018-2021
University of Helsinki
2012-2021
MRC Weatherall Institute of Molecular Medicine
2021
University of Oxford
1984-2021
Regenerative Medicine Institute
2020
Farmak (Czechia)
2019
Finland University
2011
University of Colorado System
2009
University of Colorado Boulder
2003-2007
Pharmacological evaluation of nicotine-stimulated dopamine release from striatum has yielded data consistent with activation a single population nicotinic acetylcholine receptors (nAChR). However, discovery that α-conotoxin MII (α-CtxMII) partially inhibits the response indicates two classes presynaptic nAChRs mediate release. We have investigated pharmacology and subunit composition these nAChR. Inhibition mouse striatal synaptosomes by α-CtxMII occurs within minutes; recovery is slow. The...
Nigrostriatal dopaminergic neurons express many nicotinic acetylcholine receptor (nAChR) subunits capable of forming multiple nAChR subtypes. These subtypes are expressed differentially along the neuron and presumably mediate diverse responses. beta3 subunit mRNA has restricted expression but is abundant in substantia nigra ventral tegmental areas. To investigate potential role(s) receptors containing tracts, we generated mice with a null mutation gene. We were thereby able to identify...
Subtypes of nicotinic acetylcholine receptors (nAChR) containing α6 subunits comprise 25 to 30% the presynaptic nAChRs expressed in striatal dopaminergic terminals rodents and 70% monkeys. This class receptors, potentially important nicotine addiction, binds α-conotoxin MII (α-CtxMII) with high affinity is heterogeneous, consisting several subtypes mice, possibly an consideration for design compounds that selectively activate or antagonize subclass nAChRs. Selected-null mutant mice were bred...
The well known 2.8 eV luminescence band in quartz has been studied using optically detected magnetic resonance (ODMR). A triplet state with a very large fine-structure splitting is found to contribute the emission. principle axes of are identified. possibility that originates decay self-trapped exciton involving transient oxygen Frenkel pair discussed.
Chronic nicotine treatment elicits a brain region-selective increase in the number of high-affinity agonist binding sites, phenomenon termed up-regulation. Nicotine-induced up-regulation α4β2-nicotinic acetylcholine receptors (nAChRs) cell cultures results from increased assembly and/or decreased degradation nAChRs, leading to nAChR protein levels. To evaluate whether mouse an subunit proteins, C57BL/6 mice were treated with by chronic intravenous infusion. Tissue sections prepared, and...
Journal Article Analysis of Detailed Phenotype Profiles Reveals CHRNA5-CHRNA3-CHRNB4 Gene Cluster Association With Several Nicotine Dependence Traits Get access Ulla Broms, Ph.D., Ph.D. 1Department Public Health, Hjelt Institute, University Helsinki, Finland2Department Mental Health and Substance Abuse Services, National Institute for Welfare, Finland Search other works by this author on: Oxford Academic PubMed Google Scholar Juho Wedenoja, M.D. Finland3Department Chronic Disease Prevention,...
The aim of this study was to examine the emotions higher education teachers associate with assessment and factors in their teaching environment that triggered these emotions. As a starting point, Frenzel's model teacher Pekrun's control-value theory achievement were used. sample consisted 16 experienced pedagogically advanced who participated semi-structured interviews. After abductive content analyses, both positive negative detected corresponding models. main sources validity assessment,...
Based on social cognitive theory, this study focused how self-efficacy beliefs were related to assessment practices among experienced university teachers. The data consisted of 16 thematic interviews teachers from various faculties who had received awards excellence in teaching. content analyzed both inductively and deductively. Academics' experiences four modes: general, diagnostic assessment, formative summative assessment. Sources experience identified by mastery experience, vicarious...
The effects of acute nicotine (0.5 mg/kg, s.c.) on dopamine (DA) metabolism and Fos protein expression in striatal limbic areas rats the seventh day chronic infusion (4 mg · kg<sup>−1</sup> · d<sup>−1</sup>) after 24 or 72 hr withdrawal were investigated. In saline-infused rats, elevated 3,4-dihydroxyphenylacetic acid (DOPAC) homovanillic (HVA) concentrations significantly. During infusion, no such increases seen striatum, but HVA was somewhat elevated. After when found...
Abstract Immunolabeling of β2 and α4 subunits was quantitated in brain sections (14 μm) using [ 125 I]mAb 270 299, respectively. Specificity demonstrated by signal loss −/− sections, Even mild paraformaldehyde fixation severely affected immunolabeling, so this study used unfixed sections. autoradiography to map quantitate the effects subunit‐null mutations on their putative partner subunits' protein expression. 299 labeling nearly eliminated although dorsal interpeduncular nucleus (IPN)...
Nicotinic acetylcholine receptors (nAChR) of the α6β2* subtype (where *indicates possible presence additional subunits) are prominently expressed on dopaminergic neurons. Because this, their role in tobacco use and nicotine dependence has received much attention. Previous studies have demonstrated that α6β2*-nAChR down-regulated following chronic exposure (unlike other subtypes been investigated - most α4β2* nAChR). This study examines, for first time, effects across a comprehensive dose...
In order to meet the expectations act as an expert in health care profession, it is of utmost importance that pharmacy education creates knowledge and skills needed today's working life. Thus, planning curriculum should be based on relevant up-to-date learning outcomes. University Helsinki, a university wide reform called 'the Big Wheel' was launched 2015. After reform, basic degrees are two-cycle (Bachelor-Master) competence-based, where outcomes form solid basis for goals implementation....
Journal Article Associations of Nicotine Intake Measures With CHRN Genes in Finnish Smokers Get access Kaisu Keskitalo-Vuokko, Ph.D., Ph.D. 1Department Public Health, Hjelt Institute, University Helsinki, Finland Search for other works by this author on: Oxford Academic PubMed Google Scholar Janne Pitkäniemi, Ulla Broms, Finland2Department Mental Health and Alcohol Abuse Services, National Institute Welfare (THL), Markku Heliövaara, M.D., 2Department Arpo Aromaa, Markus Perola,...