A5102849724- Inflammatory mediators and NSAID effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Clinical practice guidelines implementation
- Cancer, Stress, Anesthesia, and Immune Response
- Antibiotic Resistance in Bacteria
- Eicosanoids and Hypertension Pharmacology
- Esophageal Cancer Research and Treatment
- Venous Thromboembolism Diagnosis and Management
- Antibiotic Use and Resistance
- Kruppel-like factors research
- Acute Myeloid Leukemia Research
- RNA Research and Splicing
- Chronic Lymphocytic Leukemia Research
- Antibiotics Pharmacokinetics and Efficacy
- Estrogen and related hormone effects
- Neuroblastoma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Cancer Cells and Metastasis
- Cancer therapeutics and mechanisms
University of Sussex
2018-2025
Bangor University
2023-2024
Cardiff University
2011-2023
Public Health Wales
1997-2022
Hywel Dda University Health Board
2016-2021
Swiss Federal Institute of Sport Magglingen SFISM
2020
University of Bristol
2014-2019
Shionogi (United States)
2016-2018
Cochrane
2012-2016
Cancer Research UK
2015
Abstract Background Carbapenem-resistant (CR) Gram-negative pathogens are recognized as a major health concern. This study examined the prevalence of infections due to 4 CR species (Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli) in United States assessed their impact on hospital stays mortality. Methods Hospitalized patients with laboratory-confirmed infection any were identified from Premier Healthcare Database. Proportions calculated by...
Abstract Aspirin as a possible treatment of cancer has been increasing interest for over 50 years, but the balance risks and benefits remains point contention. We summarise valid published evidence ‘for’ ‘against’ use aspirin we present what believe are relevant ethical implications. Reasons include taken by patients with upon biological mechanisms. These explain observed reductions in metastatic vascular complications patients. Meta-analyses 118 observational studies mortality give...
// Gabriella Cunha Vieira 1, * , S. Chockalingam Zsombor Melegh 2 Alexander Greenhough 3 Sally Malik 1 Marianna Szemes Ji Hyun Park Abderrahmane Kaidi Li Zhou 4 Daniel Catchpoole Rhys Morgan David O. Bates 5 Peter Gabb Karim Cancer Epigenetics Laboratory and, School of Cellular & Molecular Medicine, University Bristol, UK Department Pathology, Southmead Hospital, Colorectal Laboratory, The Kids Research Institute, Children's Hospital at Westmead, New South Wales, Australia Biology, Division...
Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and implicated leukemogenesis. Nuclear-localized β-catenin indicative of active Wnt observed acute leukemia (AML) patients; however, some patients exhibit little or no nuclear even where cytosolic abundant. Control the subcellular localization therefore represents an additional mechanism regulating hematopoietic cells. To investigate factors mediating nuclear-localization β-catenin, we carried out first...
Canonical Wnt signaling regulates the transcription of T-cell factor (TCF)-responsive genes through stabilization and nuclear translocation transcriptional co-activator, β-catenin. Overexpression β-catenin features prominently in acute myeloid leukemia (AML) has previously been associated with poor clinical outcome. γ-catenin mRNA (a close homologue β-catenin) also reported AML linked to pathogenesis this disease, however, relative roles these catenins remains unclear. Here we report that...
PDK1 is a master kinase that activates at least six protein groups including AKT, PKC and S6K potential target in the treatment of range malignancies. Here we show overexpression over 40% myelomonocytic acute leukemia patients. Overexpression occurred uniformly throughout leukemic population, putative leukemia-initiating cells. Clinical outcome analysis revealed was associated with poorer outcome. Primary myeloid blasts over-expressing showed improved vitro survival ectopic expression...
3D tissue culture provides a physiologically relevant and genetically tractable system for studying normal malignant human tissues. Despite this, gene-silencing studies using siRNA has proved difficult. In this study, we have identified cause why traditional transfection techniques are ineffective in eliciting gene silencing situ within cultures proposed simple method significantly enhancing entry into spheroids/organoids. 2D cell culture, the efficiency of is reduced when complexes prepared...
<ns3:p>We present a genome assembly from an individual female <ns3:italic>Vipera berus</ns3:italic> (common adder; Chordata; Lepidosauria; Squamata; Viperidae). The haplotype-resolved contains two haplotypes with total lengths of 1,695.0 megabases and 1,476.7 megabases, respectively. Most haplotype 1 (98.45%) is scaffolded into 19 chromosomal pseudomolecules, while 2 assembled to scaffold level. mitochondrial has also been 17.35 kilobases in length.</ns3:p>
<title>Abstract</title> Wnt/β-catenin signaling is important for normal hematopoietic stem/progenitor cell (HSPC) biology and heavily implicated in acute myeloid leukaemia (AML). The central mediator β-catenin an attractive therapeutic target AML however its targeting has been hampered by a poor characterisation of molecular interactions haematopoietic cells, which will differ from network solid tissues. Our previous interactome study identified the significant enrichment RNA-binding...
Abstract Wnt/β-catenin signalling is important for normal hematopoietic stem/progenitor cell (HSPC) biology and heavily implicated in acute chronic myeloid leukaemia (AML CML). The central mediator β-catenin an attractive therapeutic target neoplasms however its targeting has been hampered by a poor characterisation of molecular interactions haematopoietic cells, which will differ from network solid tissues. Our previous interactome study identified the significant enrichment RNA-binding...
Background: The aim of this study was to screen the prevalence supplement use in Swiss fitness center users and what information sources they consulted. Methods: Customers 10 centers were screened with a quantitative questionnaire. Results: Eighty two percent 417 consumed at least one per week. Supplement intake correlated training frequency (rs = 0.253, p < 0.001). most prevalent products protein supplements (used by 49% population), magnesium (34%), multi-micronutrient (31%). average...
Leading articleNon-steroidal anti-inflammatory drugs and the chemoprevention of colorectal oesophageal cancers In recent years, several areas biological research have increasingly supported suggestion that aspirin other non-steroidal (NSAIDs) may reduce occurrence or progression and, to a lesser extent, cancer both.This is by consistent biochemical, pharmacological, toxicological, clinical, epidemiological messages.This leading article reviews evidence demonstrates how these diverse studies...