A5079216061- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Platelet Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Drug-Induced Adverse Reactions
- Skin and Cellular Biology Research
- Shoulder Injury and Treatment
- Systemic Lupus Erythematosus Research
- Cutaneous lymphoproliferative disorders research
- Nail Diseases and Treatments
- Dermatologic Treatments and Research
- Contact Dermatitis and Allergies
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Hair Growth and Disorders
- Toxin Mechanisms and Immunotoxins
- Vasculitis and related conditions
- Orthopedic Infections and Treatments
- Autoimmune and Inflammatory Disorders
- Mast cells and histamine
- Orthopedic Surgery and Rehabilitation
- Monoclonal and Polyclonal Antibodies Research
- Skin Diseases and Diabetes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Atlanta Gastroenterology Associates
2015-2025
Broad Institute
2024-2025
Plano Orthopedic Sports Medicine & Spine Center
2018-2023
University of Rochester
2022
Plano Cancer Institute
2019
Wansbeck General Hospital
2018
Stryker (United States)
2014
David Grant USAF Medical Center
2013
Grant Medical Center
2010-2013
Universidad de Antioquia
2013
Abstract Prion disease is a fatal neurodegenerative caused by the misfolding of prion protein (PrP) encoded PRNP gene. While there currently no cure for disease, depleting PrP in brain an established strategy to prevent or stall templated PrP. Here we developed vivo cytosine and adenine base strategies delivered adeno-associated viruses permanently modify locus achieve knockdown mouse brain. Systemic injection dual-adeno-associated virus PHP.eB encoding BE3.9max single guide RNA installing...
Context: Type IV collagen is a type of found primarily in the skin within basement membrane zone. The C4 domain at C-terminus not removed post-translational processing, and fibers are thus link head-to-head, rather than parallel fashion. Also, lacks glycine every third amino-acid residue necessary for tight helix. Thus, overall collagen-IV conformation structurally more pliable kinked, relative to other subtypes. These structural features allow form sheets, which primary cutaneous basal...
Background: Patients suffering from a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America (El Bagre-EPF) produce autoantibodies (Abs) to different proteins the skin (frustre form), as well those other organs (Senear-Usher-like and systemic forms). Here, we hypothesize whether patients' play role triggering epicardium pericardium autoimmunity pathogenicity. We based this hypothesis on knowing that these patients frequently show clinical symptoms chest heart,...
Acne scarring is a common manifestation that remains therapeutic challenge to dermatologists, dermatologic surgeons, and plastic surgeons. Although multiple modalities exist, treatment often inadequate. The use of high-concentration (95%) trichloroacetic acid (TCA) applied focally atrophic acne scars has been described.The current study confirms the utility focal application 95% TCA in addition histologic examination this technique.Acne three patients were treated with by serial application....
The purpose of this study was to compare 6 different graft fixation techniques determine the preparation speed, security, biomechanical strength, and resultant tissue trauma.Six (10 samples each): #2 OrthoCord Krackow stitch, FiberWire SpeedTrap, WhipKnot, Loop-in-loop stitch were created in distal 3 cm 9 bovine flexor tendons. proximal tendon segment clamped a testing machine suture ends secured by pneumatic grips. preload cycles (10N-100N) 50N static load followed 500 (50N-200N) then...
PurposeTo evaluate the biomechanical characteristics of recently introduced meniscal repair devices with a hand-tied, inside-out suture in human meniscus model.MethodsIn detached adult menisci, vertical longitudinal cuts were created 3 mm from synovial-meniscal junction, simulating bucket-handle tear. Each cut was repaired using single device. Group 1 received mattress No. 2-0 OrthoCord; group 2, TrueSpan device PEEK (polyether ether ketone) anchors containing OrthoCord suture; 3,...
We reviewed our institutional experience with de novo CD5+, large B-cell lymphomas to determine whether they represent a distinct entity and are related CD5+ small disorders. identified 13 cases multiparameter flow cytometry over period of 58 months (5% lymphomas) in 7 females 6 males. Three groups were identified. Group 1 (2 cases) had diffuse splenic red pulp involvement distinctive cordal pattern infiltration, no other clinical evidence mass disease, microscopic disseminated disease on...
The presence of prominent proliferation centers (PCs) in lymph nodes (LNs) involved with chronic lymphocytic leukemia/small lymphoma (CLL/SLL) has been associated atypical blood smear morphology. Atypical CLL turn variant immunophenotypes and poor outcome. However, the significance abundant PCs remains controversial. We have analyzed flow cytometric immunophenotypic features 54 CLL/SLL LNs correlated these findings morphologic clinical features. LN histology was assigned to one two groups...
A prospective, controlled epidemiologic survey performed in El Bagre, Colombia revealed a new variant of endemic pemphigus disease, occurring gold mining region. The disease resembled Senear-Usher syndrome, and occurred an fashion. aim this study is to describe the most frequent histopathologic patterns non-glabrous skin glabrous observed these patients, their clinical correlation. was on biopsies 30 patients from dominantly affected areas (either chest, arms or face). Simultaneously, palms...
Abstract Background and Purpose There is significant research supporting the role of pulmonary rehabilitation in chronic obstructive disease (COPD). However, less known about real‐life clinical services. Data were analysed from a service provided UK, consisting seven weeks' twice‐weekly training education. Method A retrospective study. Baseline measures consisted activity daily living, mood state, spirometry, exercise tolerance using Incremental Shuttle Walk Test (ISWT) health status St...
We previously described a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America (El Bagre-EPF). On physical examination, the palms and soles Bagre-EPF patients reveal an edematous texture mild hyperkeratosis, comparison with non-glabrous skin where blisters, pustules or other lesions are commonly found. Based on preceding observation, we tested 20 cases controls from area for any pathological alterations samples by direct immunofluorescence (DIF). Our DIF...
Autoimmune bullous skin diseases (ABDs) are uncommon, potentially fatal of and mucous membranes which associated with deposits autoantibodies complement against distinct molecules the epidermis dermal/epidermal basement membrane zone (BMZ).These lead to a loss in molecular integrity, manifests clinically as formation blisters or erosions.In pemphigus vulgaris, adhesion occurs within epidermis.The pioneering work Ernst H. Beutner, Ph.D. Robert E. Jordon, M.D. confirmed autoimmune nature these...