A5042133499- Acute Ischemic Stroke Management
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Cardiac Structural Anomalies and Repair
- Optical Imaging and Spectroscopy Techniques
- Stroke Rehabilitation and Recovery
- Thermal Regulation in Medicine
- Telomeres, Telomerase, and Senescence
- Biomarkers in Disease Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Cardiac tumors and thrombi
- Cerebrovascular and Carotid Artery Diseases
- Long-Term Effects of COVID-19
- Climate Change and Health Impacts
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Health and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Travel-related health issues
- Health Promotion and Cardiovascular Prevention
- Inflammation biomarkers and pathways
- Acute Kidney Injury Research
- Electrolyte and hormonal disorders
- Disaster Response and Management
- Inflammasome and immune disorders
University of Ulster
2023-2025
Personalis (United States)
2024
Altnagelvin Area Hospital
2024
University of Bristol
2018
The Alfred Hospital
1970-1993
University of the West Indies
1991
Cooper and Company (United States)
1976
Monash University
1970
Abstract Background Senescence associated secretory phenotype (SASP) contributes to age‐related pathology, however the role of SASP in Chronic Kidney Disease (CKD) is unclear. Here, we employ a variety omic techniques show that senescence signatures can separate CKD patients into distinct endotypes (Sendotype). Methods Using specific numbers senescent proteins, clustered two sendotypes based on proteomic expression. These clusters were evaluated with three independent criteria assessing...
Two cases of therapy with frankincense and myrrh in children are presented. The long history this unusual treatment is outlined, demonstrating that for several millenia such agents have been employed a number medical contexts, as well the perfume incense industries. Myrrh has found recent pharmacological application reduction cholesterol triglycerides, predicted by traditional therapies.
An increased incidence of obvious live-birth neural tube defects (i.e., spina bifida cystica and encephalocele) occurred in Jamaica 11 to 18 months after Hurricane Gilbert. The conceptions the affected babies coincided with a rise megaloblastic change sickle cell patients, suggesting wide-spread drop dietary folate intake. A detailed history was taken from each 17 mothers (case subjects) 51 unaffected (matched control subjects). case subjects reported significantly lower mean intake...
Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2 has posed unprecedented challenges to healthcare systems worldwide. Here, we have identified proteomic and genetic signatures for improved prognosis which is vital research. Methods: We investigated genomic profile of positive patients (n=400 proteomics, n=483 genomics), focusing on differential regulation between hospitalised non-hospitalised patients. Signatures had their predictive capabilities tested using...
Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has posed unprecedented challenges to healthcare systems worldwide. Here, we have identified proteomic and genetic signatures for improved prognosis which is vital research. Methods: We investigated genomic profile of COVID-19-positive patients (n = 400 proteomics, n 483 genomics), focusing on differential regulation between hospitalised non-hospitalised patients. Signatures had their predictive capabilities...
Health organizations and countries around the world have found it difficult to control spread of COVID-19. To minimize future impact on UK National Service improve patient care, there is a pressing need identify individuals who are at higher risk being hospitalized because severe Early targeted work was successful in identifying angiotensin-converting enzyme-2 receptors type II transmembrane serine protease dependency as drivers infection. Although approach highlights key pathways,...
In the present study, dynamics of cerebral blood flow (CBF) and ventilatory response to hypercapnia was investigated in a group patients with cerebrovascular disease compared responses measured normal volunteers. There significant correlation between rapidity transient CBF severity disease. While steady state showed no such correlation, reduced severe Various explanations for differences dynamic ventilation mild or subjects are considered. Measurement these circulatory may be sensitive means...
Summary: Five patients had recurrent ventricular tachyarrhythmias which were abolished by resection of their left aneurysms.
Cellular senescence is the irreversible growth arrest subsequent to oncogenic mutations, DNA damage or metabolic insult. Senescence associated with aging and chronic age diseases such as cardiovascular disease diabetes. The involvement of cellular in Acute Kidney Injury (AKI) Chronic Disease (CKD) not fully understood however, recent studies suggest that patients have a higher-than-normal level accelerated aging. This study aimed discover key biomarkers AKI CKD compared other ageing...
Cellular senescence is the irreversible growth arrest subsequent to oncogenic mutations, DNA damage, or metabolic insult. Senescence associated with ageing and chronic age diseases such as cardiovascular disease diabetes. The involvement of cellular in acute kidney injury (AKI) (CKD) not fully understood. However, recent studies suggest that patients have a higher-than-normal level accelerated ageing.
Forty-six patients had a total of 51 fresh autologous fascia lata valves inserted during 12-month period. There were 27 single aortic replaced, with an overall mortality rate 37%, and reoperation 18%, owing to valve breakdown. Late non-infective breakdown occurred in one patient aged 71 years at the time initial operation. Fourteen mitral replacements performed, 43% 36%, Three developed their between three 13 months after The macroscopic conditions these similar, as results comparisons...
Abstract Objective The Covid Response Study (COVRES, NCT05548829) aims to carry out an integrated multi-omic analysis of factors contributing host susceptibility SARS-CoV-2 among a patient cohort 1000 people from the geographically isolated island Ireland. Background Health organisations and countries around world have found it difficult control spread coronavirus disease 2019. To minimise impact on NHS improve care, there is drive for rapid tests capable detecting individuals who are at...
<sec> <title>BACKGROUND</title> Health organizations and countries around the world have found it difficult to control spread of COVID-19. To minimize future impact on UK National Service improve patient care, there is a pressing need identify individuals who are at higher risk being hospitalized because severe Early targeted work was successful in identifying angiotensin-converting enzyme-2 receptors type II transmembrane serine protease dependency as drivers infection. Although approach...