A5017670128- Suicide and Self-Harm Studies
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 Clinical Research Studies
- Mental Health Treatment and Access
- SARS-CoV-2 and COVID-19 Research
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Photoreceptor and optogenetics research
- Long-Term Effects of COVID-19
- Resilience and Mental Health
- Immune Cell Function and Interaction
- Maternal Mental Health During Pregnancy and Postpartum
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- COVID-19 and Mental Health
- Musculoskeletal pain and rehabilitation
- Ovarian function and disorders
- Birth, Development, and Health
- Circadian rhythm and melatonin
- Chronic Disease Management Strategies
- Hemoglobin structure and function
- Thermal Regulation in Medicine
- Adolescent and Pediatric Healthcare
- Child Abuse and Trauma
- Hypothalamic control of reproductive hormones
University of Ulster
2014-2025
Altnagelvin Area Hospital
2017-2025
Personalis (United States)
2024
Allogene Therapeutics (United States)
2023
Pfeiffer University
2023
Vhi Healthcare
2019
University of Massachusetts Amherst
2008-2013
King's College Hospital NHS Foundation Trust
2010
Salisbury NHS Foundation Trust
2010
Enable Ireland
2010
Increasingly, colleges across the world are contending with rising rates of mental disorders, and in many cases, demand for services on campus far exceeds available resources.The present study reports initial results from first stage WHO World Mental Health International College Student project, which a series surveys 19 8 countries (Australia, Belgium, Germany, Mexico, Northern Ireland, South Africa, Spain, United States) were carried out aim estimating prevalence basic sociodemographic...
Warm-up and stretching are suggested to increase hamstring flexibility reduce the risk of injury. This study examined short-term effects warm-up, static dynamic on in individuals with previous injury uninjured controls. A randomised crossover design, over 2 separate days. Hamstring was assessed using passive knee extension range motion (PKE ROM). 18 previously injured controls participated. On both days, four measurements PKE ROM were recorded: (1) at baseline; (2) after warm-up; (3) stretch...
Abstract The principal nucleus of the bed stria terminalis (BNSTp) is larger in volume and contains more cells male than female mice. These sex differences depend on testosterone arise from a higher rate cell death during early postnatal life females. There delay several days between surge at birth sexually dimorphic BNSTp, suggesting that epigenetic mechanisms may be involved. We tested hypothesis chromatin remodeling plays role sexual differentiation BNSTp by manipulating balance histone...
Mental health and behavioural problems are common among students commencing university. University life can be stressful often exacerbate during their course of study, while others develop disorders for the first time. The WHO World Health Surveys International College Student Project aims to conduct longitudinal research examine monitor student mental wellbeing. Ulster Wellbeing which commenced in September 2015 Northern Ireland (NI), was conducted as part this initiative (wave 1, n = 739),...
A growing body of evidence supports an important role for alterations in the brain-gut-microbiome axis aetiology depression and other psychiatric disorders. The potential oral microbiome mental health has received little attention, even though it is one most diverse microbiomes dysbiosis been linked to systemic diseases with underlying inflammatory aetiology. This study examines structure composition salivary first time young adults who met DSM-IV criteria (n = 40) matched controls 43) using...
Abstract Background Senescence associated secretory phenotype (SASP) contributes to age‐related pathology, however the role of SASP in Chronic Kidney Disease (CKD) is unclear. Here, we employ a variety omic techniques show that senescence signatures can separate CKD patients into distinct endotypes (Sendotype). Methods Using specific numbers senescent proteins, clustered two sendotypes based on proteomic expression. These clusters were evaluated with three independent criteria assessing...
The Kiss1 gene and its product kisspeptin are important regulators of reproduction. In rodents, is expressed in the hypothalamic arcuate (ARC) anteroventral periventricular (AVPV)/rostral (PeN) nuclei. AVPV/PeN, females have more tyrosine hydroxylase (TH) neurons than males. We explored ontogeny sex difference, role cell death establishing TH number. also determined whether cells AVPV/PeN coexpress TH. were first detected both sexes on postnatal d 10, but difference did not emerge until 12....
Many students struggle with psychological problems during their college years. These may be even more apparent the COVID-19 pandemic accompanying restrictions and transition to an online learning environment, but few longitudinal studies have been conducted date. The aim of this study was compare symptoms depression, anxiety suicidality prior pandemic, identify stressors.This among attending Ulster University, Northern Ireland (NI) LYIT, Republic (ROI), as part World Mental Health...
We examined neurotrophin and receptor tyrosine kinase (Trk) expression in the bladder major pelvic ganglia (MPG) after cyclophosphamide induced cystitis rats.The MPG were used immunohistochemical studies, enzyme-linked immunoassays Western blots for nerve growth factor (NGF), brain-derived neurotrophic (BDNF), TrkA TrkB. Bladder postganglionic cells labeled by tracing techniques.NGF BDNF was decreased of all rats (p < or =0.001). NGF increased male with =0.01). Cells expressing TrkB...
Naturally occurring cell death is essential to the development of mammalian nervous system. Although importance developmental has been appreciated for decades, there no comprehensive account across brain areas in mouse. Moreover, several regional sex differences have described ventral forebrain and hypothalamus, but it not known how widespread phenomenon is. We used immunohistochemical detection activated caspase-3 identify dying cells brains male female mice from postnatal day (P) 1 P11....
Early life experiences, such as childhood adversities or poor parenting practices, can impact on the ability to cope with stressors across lifespan. Furthermore, coping skills lead development of mental illnesses, self-harm, and suicidal behavior. This study aimed examine demographic differences in stress levels determine if those who had endured negative experiences would be more likely develop psychological problems display behavior when current were accounted for. The also explored link...
Despite the well-established role of vasopressin (AVP) in adult social behavior, its development is relatively unexplored. In this paper, we focus on most prominent behavior juvenile rats, play. Previous pharmacological experiments our laboratory suggested that AVP regulates play a sex- and brain region-specific manner rats. Here investigate specific systems emergence We first characterize male female Wistar rats then ask whether mRNA expression correlates with Unexpectedly, emerged more...
Abstract Alterations in the expression of neuropeptide galanin were examined micturition reflex pathways 6 weeks after complete spinal cord transection (T8). In control animals, was present specific regions gray matter rostral lumbar and caudal lumbosacral cord, including: (1) dorsal commissure; (2) superficial horn; (3) intermediolateral cell column (L1–L2) sacral parasympathetic nucleus (L6–S1); (4) lateral collateral pathway segments. Densitometry analysis demonstrated significant...
SARS-CoV-2 has claimed more than 7 million lives worldwide and been associated with prolonged inflammation, immune dysregulation persistence of symptoms following severe infection. Understanding the T cell mediated response factors impacting development continuity specific memory cells is pivotal for developing better therapeutic monitoring strategies those most at risk from COVID-19. Here we present a comprehensive analysis in convalescent cohort (n=20), three months post Omicron Utilising...
To investigate the associations of demographic variables, childhood adversities (CAs), and mental disorders (MDx) with onset, transition, persistence suicidal thoughts behaviors (STB) among first-year university students. Poisson regression models within a discrete-time survival framework were constructed using web-based self-report survey data from 72,288 incoming students across 18 countries (response rate=20.9%; median age=19 years, 57.9% female, 1.4% transgender, 21.0% non-heterosexual)....
Recent findings demonstrate that epigenetic modifications are required for the sexual differentiation of brain. For example, neonatal administration histone deacetylase inhibitor, valproic acid, blocks masculinisation cell number in principal nucleus bed stria terminalis (BNST). In present study, we examined effects acid on neurochemistry and behaviour, focusing traits sexually dimorphic linked to BNST. Newborn mice were treated with saline or effect vasopressin immunoreactivity olfactory...