A5042112942- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect symbiosis and bacterial influences
- Insect Resistance and Genetics
- Invertebrate Immune Response Mechanisms
- Cell death mechanisms and regulation
- Biosensors and Analytical Detection
- Viral Infections and Vectors
- Insect Pest Control Strategies
- Dengue and Mosquito Control Research
- Neurobiology and Insect Physiology Research
- Insect Utilization and Effects
- Vector-Borne Animal Diseases
- CRISPR and Genetic Engineering
- Vector-borne infectious diseases
- Parasitic Diseases Research and Treatment
- Insect and Pesticide Research
- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Microfluidic and Bio-sensing Technologies
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Insect behavior and control techniques
- SARS-CoV-2 detection and testing
- Toxoplasma gondii Research Studies
Jikei University School of Medicine
2015-2024
Obihiro University of Agriculture and Veterinary Medicine
2006-2022
The University of Tokyo
1996-2012
RIKEN Center for Brain Science
2002-2005
Osaka University
1997-2003
Keio University
2003
Japan Science and Technology Agency
2000
University of Tsukuba
1999
Tokyo University of Science
1998-1999
Interleukin (IL)-1 is a major mediator of inflammation and exerts pleiotropic effects on the neuro-immuno-endocrine system. To elucidate pathophysiological roles IL-1, we have first produced IL-1α/β doubly deficient (KO) mice together with in either IL-1α, IL-1β, or IL-1 receptor antagonist (IL-1ra) genes. These were born healthy, their growth was normal except for IL-1ra KO mice, which showed retardation after weaning. Fever development upon injection turpentine suppressed IL-1β as well but...
We identified Wengen, the first member of Drosophila tumor necrosis factor receptor (TNFR) superfamily. Wengen is a type III membrane protein with conserved cysteine-rich residues (TNFR homology domain) in extracellular domain, hallmark TNFR wengen mRNA expressed at all stages development. The small-eye phenotype caused by an eye-specific overexpression TNF superfamily ligand, Eiger, was dramatically suppressed down-regulation using RNA interference. In addition, and Eiger physically...
Pathogen-associated secretion systems translocate numerous effector proteins into eukaryotic host cells to coordinate cellular processes important for infection. Spatiotemporal regulation is therefore modulating distinct activities of effectors at different stages Here we provide the first evidence "metaeffector," a designation an protein that regulates function another within cell. Legionella LubX functions as E3 ubiquitin ligase hijacks proteasome specifically target bacterial SidH...
Once animals have experienced a helminthic infection, they often show stronger protective immunity against subsequent infections. Although infections are well known to elicit Th2-type immune responses, it remains ill-defined where and how acquired protection is executed. Here we that skin-invading larvae of the intestinal helminth Nippostrongylus brasiliensis surrounded by skin-infiltrating cells prevented from migrating out infected skin during second but not first infection. B cell– or IgE...
A critical stage in malaria transmission occurs the Anopheles mosquito midgut, when parasite, Plasmodium, ingested with blood, first makes contact gut epithelial surface. To understand response mechanisms within midgut environment, including those influenced by resident microbiota against we focus on a bacteria species' intra-specific variation that confers diversity to mosquito's competency for transmission. Serratia marcescens isolated from either laboratory-reared mosquitoes or wild...
Significance The GATA-1 transcription factor has been extensively characterized and shown to play crucial roles in the development of erythroid cells, magakaryocytes, eosinophils, mast cells. However, role basophils remained unidentified. We demonstrate that knockdown Gata1 gene expression results impaired cytokine production upon allergen-mediated activation. Moreover, ΔdblGATA mice carrying mutated promoter have reduced numbers their progenitors show responses basophil-mediated protective...
We must ensure that trials are scientifically, politically, and socially robust, publicly accountable, widely transparent
Severe fever with thrombocytopenia syndrome virus (SFTSV) is spreading rapidly in Asia. This transmitted by the Asian longhorned tick (Haemaphysalis longicornis), which has parthenogenetically and sexually reproducing populations. Parthenogenetic populations were found ≥15 provinces China strongly correlated distribution of severe cases. However, these cases was poorly bisexual ticks. Phylogeographic analysis suggested that parthenogenetic population spread much faster than because...
The Bcl-2/CED-9 family of proteins, which includes both antiapoptotic and proapoptotic members, plays key regulating roles in programmed cell death. We report here the identification characterization Drob-1, first Drosophila member to be isolated. Drob-1 contains four conserved Bcl-2 homology domains (BH1, BH2, BH3, BH4) a C-terminal hydrophobic domain. Ectopic expression developing eye resulted rough-eye phenotype. Furthermore, when overexpressed S2 cells, induced apoptosis accompanied by...
Resistance to pyrethroid insecticides involving kdr mutations is widespread in Aedes aegypti (L.) (Diptera: Culicidae) and potentially could impact control efforts endemic countries. Dengue cases had been sporadic Burkina Faso for over a decade prior the 2016–2017 outbreak that resulted 15,074 suspected 36 deaths, mainly Ouagadougou. These outbreaks highlighted lack of information on numerous aspects biology, behaviour insecticide status local dengue vector populations are fundamental...
Background Recent outbreaks of dengue and other Aedes aegypti-borne arboviruses highlight the importance a rapid response for effective vector control. Data on insecticide resistance underlying mechanisms are essential outbreak preparedness, but sparse in much Africa. We investigated levels heterogeneity Ae. aegypti from contrasting settings within around Ouagadougou, Burkina Faso. Methodology/Principal findings Bioassays were performed larvae adults to diagnose prevalence resistance, assess...
Abstract Background Mosquito control is a crucial global issue for protecting the human community from mosquito-borne diseases. There an urgent need development of selective and safe reagents mosquito control. Flavonoids, group chemical substances with variable phenolic structures, such as daidzein, have been suggested potential larvicides less risk to environment. However, mode larvicidal action flavonoids has not elucidated. Results Here, we report that several flavonoids, including...
In metazoan development, the precise mechanisms that regulate completion of morphogenesis according to a developmental timetable remain elusive. The Drosophila male terminalia is an asymmetric looping organ; internal genitalia (spermiduct) loops dextrally around hindgut. Mutants for apoptotic signaling have orientation defect their terminalia, indicating apoptosis contributes morphogenesis. However, physiological roles in been unclear. Here, we show role organogenesis using time-lapse...
Background Dengue’s emergence in West Africa was typified by the Burkina Faso outbreaks 2016 and 2017, nation’s largest to date. In both years, we undertook three-month surveys of Aedes populations or near capital city Ouagadougou, where were centered. Methodology 1200LG (urban), Tabtenga (peri-urban) Goundry (rural) localities, collected indoor outdoor resting mosquito adults, characterized larval habitats containers producing pupae reared immature stages adulthood laboratory for...
Despite recent advances in our understanding of the basic biology behind transmission zoonotic infectious diseases harbored by arthropod vectors these remain threatening public health concerns. For effective control vector and treatment, precise sampling indicating prevalence such is essential. With an aim to develop a quick simple method survey pathogen-transmitting vectors, LAMP (loop-mediated isothermal amplification) was applied detection filarial parasites using parasite-transmitting...