A5009839850- Ethics in Clinical Research
- Global Cancer Incidence and Screening
- Hemoglobinopathies and Related Disorders
- Palliative Care and End-of-Life Issues
- Iron Metabolism and Disorders
- Health Policy Implementation Science
- Health and Medical Research Impacts
- Economic and Financial Impacts of Cancer
- Racial and Ethnic Identity Research
- Health Systems, Economic Evaluations, Quality of Life
- Mobile Health and mHealth Applications
- Migration, Health and Trauma
- Global Health Workforce Issues
- Cultural Competency in Health Care
- Health Literacy and Information Accessibility
- Healthcare Policy and Management
- Social Media in Health Education
- Geriatric Care and Nursing Homes
- Pharmacological Effects and Toxicity Studies
- Health Sciences Research and Education
- Grief, Bereavement, and Mental Health
- Advances in Oncology and Radiotherapy
- Primary Care and Health Outcomes
- Interprofessional Education and Collaboration
- Breast Cancer Treatment Studies
Wake Forest University
2024-2025
Levine Cancer Institute
2024-2025
Duke University
2014-2025
Atrium Health Wake Forest Baptist
2024-2025
Wake Forest Baptist Comprehensive Cancer Center
2024-2025
Duke Cancer Institute
2015-2024
Duke Institute for Health Innovation
2016-2024
Duke Medical Center
2013-2024
American Association of Neurological Surgeons
2023
Southern California Clinical and Translational Science Institute
2023
A concerted commitment across research stakeholders is necessary to increase equity, diversity, and inclusion (EDI) address barriers cancer clinical trial recruitment participation. Racial ethnic diversity among participants key understanding intrinsic extrinsic factors that may affect patient response treatments. This ASCO Association of Community Cancer Centers (ACCC) Research Statement presents specific recommendations strategies for the community improve EDI in trials. There are six...
Certain cultural, folk, and religious beliefs that are more common among African Americans (AAs) have been associated with later-stage breast cancer. It is unknown if these similarly delays in diagnosis of ovarian cancer.Data from a multicenter case-control study cancer AA women were used to examine associations between cultural/folk practices stage at symptom duration before diagnosis. Associations or assessed logistic regression analyses, linear analyses.Agreement several the belief...
<p><strong>Purpose: </strong>To examine barriers recruiters encounter when enrolling African American study participants, identify motivating factors to increase research participation, and provide recommendations facilitate successful minority recruitment. </p><p><strong>Background: </strong>Recruiters are often the first point of contact between potential participants. While challenges in Americans into clinical epidemiologic has been reported...
Background Telehealth is an increasingly important component of health care delivery in response to the COVID-19 pandemic. However, well-documented disparities persist use digital technologies. Objective This study aims describe smartphone and internet within a diverse sample, assess association with markers literacy access, identify mediating factors these relationships. Methods Surveys were distributed targeted sample designed oversample historically underserved communities from April 2017...
Background Engaging diverse populations in biomedical research, including biospecimen donation, remains a national challenge. This study examined factors associated with an invitation to participate intent research the future, and participation donation among diverse, multilingual, community‐based sample across 3 distinct geographic areas. Methods Three National Cancer Institute–designated cancer centers engaged community partnerships develop implement population health assessments, reaching...
Cancer trial participants do not reflect the racial and ethnic diversity in population of people with cancer United States. As a result multiple system-, patient-, provider-level factors, including implicit bias, clinical trials are consistently offered to all potentially eligible patients.ASCO ACCC evaluated utility (pre- post-test knowledge changes) feasibility (completion rates, curriculum satisfaction metrics, survey questions, interviews) customized online training program combined...
Advance care planning (ACP) improves end-of-life for patients and their caregivers. However, only one-third of adults have participated in ACP rates are substantially lower among African Americans than whites. Importantly, many domains where there racial disparities outcomes, including receipt goal-concordant care, hospice use, provider communication. Yet, few studies examined the effectiveness interventions Americans. The objectives reducing quality palliative older through improved advance...
BackgroundThe extent to which healthcare worker (HCWs) experiences during the COVID-19 pandemic vary by race or ethnicity after adjustment for confounding factors is not currently known.MethodsWe performed an observational prospective cohort study of 24,769 workers from 50 U.S. states and District Columbia, enrolled between April 10, 2020 June 30, 2021, evaluated participant pandemic, including testing, diagnosis with COVID-19, emotional experiences, burnout, interest in vaccines vaccine...
Individuals of recent West African ancestry develop focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (HTN-ESKD) at 4 times the rate White Americans. Two protein-coding variants Apolipoprotein L1 (APOL1) gene, G1 G2, explain 50% to 70% excess risk HTN-ESKD FSGS among this group. Increased expression G2 in kidney, mediated by Janus kinase/signal transducer activator transcription (JAK-STAT) signaling, drive pathogenesis these diseases. Baricitinib...
People of African ancestry are overrepresented among lives lost prematurely and persons unnecessarily afflicted with the highest burden cancer nonindigenous Americans. Amid growing advancements in discoveries innovations, persistence disparities affecting Black/African American populations is particularly disturbing disappointing. Ashing colleagues Alliance Black Community Outreach Engagement Scientific Directors National Cancer Institute-designated centers discuss excessive propose a...
Objectives/Goals: Clinical trial success requires recruiting and retaining diverse participants. The ER&R Certificate Program trains clinical research professionals (CRPs) in equity, diversity, inclusion (EDI), addressing biases, integrating regulatory knowledge with practical skills to foster inclusive practices. Methods/Study Population: An interdisciplinary Steering Committee, supported by Duke CTSI DOCR, developed implemented an engagement, recruitment, retention certificate program...
Background/Objectives: Informed consent is a crucial part of the clinical trial enrollment process in which patients are asked to understand and provide approval for medical interventions. Consent forms can be complex hinder patient comprehension, highlighting need novel tools improve experience. This feasibility study aimed develop an immersive technology enroll human subjects oncology trials 3D avatar-based informed virtual reality (VR) environment. Methods: Clinical effects head-mounted...
Introduction American Indians and Alaska Natives (AIANs) experience significant cancer incidence mortality disparities, with elevated risk factor exposure, lower screening rates, poorer quality of care relative to non-Hispanic Whites. To address these issues, the Southeastern Indian Cancer health Equity Partnership (SAICEP) was formed understand disparities among southeastern (AIs). Methods SAICEP in 2021 through Community Outreach Engagement offices NCI-designated Comprehensive Centers...
The disproportionate impact of the COVID-19 pandemic on marginalized communities due to structural racism has led an increased focus diversity, equity, and inclusion in medical literature. To assess pre-pandemic racial ethnic representation among subjects palliative care research, we examined reporting race ethnicity research presented at American Academy Hospice Palliative Medicine Nurses Association State Science (SOS) plenary (2004-2019), as these articles frequently influence patient...
Summary Sickle cell disease (SCD) has a distinct pattern of transfusional iron overload (IO) when compared to transfusion‐dependent β‐thalassaemia major (TDT). We conducted single institution prospective study evaluate plasma biomarkers regulation and inflammation in patients with SCD IO (SCD cases, n = 22) without non‐IO 11), non‐SCD controls ( 13). Hepcidin was found be inappropriately low, as evidenced by significantly higher median hepcidin/ferritin ratio cases (0·3 vs. 0·02, P <...
Vaso-occlusive episodes (VOEs) are a hallmark of sickle cell disease (SCD), and account for >90% health care encounters this patient population. The Cooperative Study Sickle Cell Disease, large study enrolling >3000 patients, showed that the majority SCD patients (80%) experienced 0–3 major pain crises/year. Only small minority (~5%) ≥6 VOEs/year. Our sought to further understand difference in VOE frequency between patients. We analyzed 25 (13M/12F, mean age 28.8) with ED visits or...
Ensuring equity in research is a critical step advancing health equity. In this perspective, the authors introduce guiding framework for racial processes, environments, and among workforce, 5Ws of Racial Equity Research. Centering their discussion on 5Ws: Who, What, When, Where, Why, they use historical contemporary examples inequities to demonstrate how these five simple questions can encourage open proactive planning research. They close with an acknowledgment framework's broad utility...
Many women do not get mammography screenings at the intervals recommended for early detection and treatment of breast cancer. The Guide to Community Preventive Services (Community Guide) recommends a range evidence-based strategies improve rates. However, nurses others working in community-based settings make only limited use these strategies. We report on dissemination intervention that partnered University North Carolina with Susan G. Komen Triangle Affiliate disseminate cancer screening...