A5021823018- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Appendicitis Diagnosis and Management
- Urological Disorders and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Organ Transplantation Techniques and Outcomes
- Healthcare cost, quality, practices
- Organ Donation and Transplantation
- Tissue Engineering and Regenerative Medicine
- Trauma and Emergency Care Studies
- Minimally Invasive Surgical Techniques
- Prostate Cancer Diagnosis and Treatment
- Liver Disease and Transplantation
- Electrospun Nanofibers in Biomedical Applications
- Transplantation: Methods and Outcomes
- Renal and Vascular Pathologies
- Urinary Bladder and Prostate Research
- Surgical Simulation and Training
- Microbial Inactivation Methods
- Ureteral procedures and complications
- Climate Change and Health Impacts
- Urologic and reproductive health conditions
- Digital Imaging in Medicine
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
Addenbrooke's Hospital
2019-2025
Bedford Hospital
2023-2024
University of Cambridge
2019-2024
Bedford Hospital NHS Trust
2024
Lymphatic Education & Research Network
2024
Great Ormond Street Hospital
2012-2022
University College London
2012-2022
Cambridge University Hospitals NHS Foundation Trust
2019-2022
Saitama Medical University
2022
Limassol General Hospital
2016-2021
Hepatic tissue engineering using decellularized scaffolds is a potential therapeutic alternative to conventional transplantation. However, are usually obtained decellularization protocols that destroy the extracellular matrix (ECM) and hamper clinical translation. We aim develop technique reliably maintains hepatic microarchitecture ECM components. Isolated rat livers were by detergent-enzymatic with (EDTA-DET) or without EDTA (DET). Histology, DNA quantification proteomics confirmed further...
Tissue engineering of autologous lung tissue aims to become a therapeutic alternative transplantation. Efforts published so far in creating scaffolds have used harsh decellularization techniques that damage the extracellular matrix (ECM), deplete its components and take up 5 weeks perform. The aim this study was create natural acellular scaffold using method will reduce time production better preserve architecture ECM components. Decellularization rat lungs via intratracheal route removed...
Introduction Use of mobile devices with high-quality cameras has expanded medical photography. We investigate the impact different and conditions on photograph quality in a surgical setting.
Abstract Introduction Optimising organ utilisation relies on accurate quality assessments. Though multiple factors influence decisions, subjective visual assessments of hepatic steatosis and renal perfusion remain the most reported reasons non-utilisation retrieved organs. Initial evaluations are typically conducted by trainee surgeons. This study assesses agreement between consultant transplant Methods Surgeons were categorised as consultants (≥5 years experience) or trainees (<5...
Abstract Unmatched allogeneic in utero stem cell transplantation (IUSCT) produces poor engraftment unless the fetus has congenital immunodeficiency, probably because of maternal and fetal immune responses to injected cells. We studied functional hematopoietic potential transduced green fluorescent protein (GFP+) sheep amniotic fluid (AF) cells, before after autologous IUSCT. CD34+ cells were selected from first trimester AF, overnight, intravenously into NOD-SCID-gamma (NSG) mice. At 3...
<h3>ABSTRACT</h3> 'Payment by results' (PbR) remuneration for healthcare services relies on the accurate conversion of diagnoses into Healthcare Resource Group (HRG) codes that are then reimbursed. Inconsistencies in documentation can result inaccuracies this process, with consequent implications measuring activity, disease incidence and organisational performance. The aim study was to determine if clinician involvement increases accuracy coding medical cases. Selected records patients...
Abstract There is uncertainty about the safety of kidney transplantation during SARS‐CoV‐2 pandemic due to risk donor transmission, nosocomial infection and immunosuppression use. We describe organ donation transplant practice in UK assess whether conferred a substantial harm. Data from registry were used activity UK, detailed analysis short‐term, single‐center, patient results two periods: pre‐pandemic era 30th December 2019 8th March 2020 (“Pre‐COVID era”) 9th 19th May (“COVID era”). Donor...
To determine if management of ureteric stones in the UK changed during coronavirus disease 2019 (COVID-19) pandemic and whether this affected patient outcomes.We conducted a multicentre retrospective study adults with computed tomography-confirmed stone at 39 hospitals pre-pandemic period (23/3/2019-22/6/2019) (the 3-month after first severe acute respiratory syndrome coronavirus-2 case individual sites). The primary outcome was success treatment modality, defined as no further required for...
Normothermic regional perfusion (NRP) and normothermic machine (NMP) have both been used in the procurement conditioning of abdominal organs from donation after circulatory death donors with reported improved outcomes for recipients. Here, we describe an unusual case a kidney that underwent NMP NRP. After 2 hours NRP, intra-abdominal were cold flushed situ. The liver right well flushed, but left was poorly flushed. Further attempts to clear by flushing on backtable unsuccessful, thought be...
Enterocystoplasty is adopted for patients requiring bladder augmentation, but significant long-term complications highlight need alternatives. We established a protocol creating natural-derived extracellular matrix (BEM) developing tissue-engineered bladder, and investigated its structural functional characteristics.Porcine bladders were de-cellularised with dynamic detergent-enzymatic treatment using peristaltic infusion. Samples fresh controls evaluated histological staining,...
To analyse the contemporary management of renal injuries in a UK major trauma centre and to evaluate utility value re-imaging.The prospectively maintained 'Trauma Audit Research Network' database was interrogated identify patients with urinary tract between January 2014 December 2017. Patients' records imaging were reviewed injury grades, interventions, outcomes, follow-up.Renal identified 90 (79 males 11 females). The mean (sd; range) age 35.5 (17.4; 1.5-94) years. Most traumas caused by...
Papillary carcinoma of the thyroid is commonest type cancer. Laryngeal infiltration from papillary extremely rare, with only a few cases partial invasion described in literature. We present very unusual case complete both and cricoid cartilages neglected 59-year-old male. This sequel resulted refusal patient to undergo treatment when initially diagnosed. An such an extent has not been literature before, this warranted total laryngectomy followed by radioactive iodine. Prompt management...
Takotsubo cardiomyopathy, a rare stress-related has been observed in few cases secondary to systemic lupus erythematosus (SLE). Herein, we report an unusual case where postmenopausal woman presented initially with syndrome, later developed thrombotic thrombocytopenic purpura and cerebrovascular events, without clinical or laboratory features of SLE. During the course her illness, she was found satisfy four Systemic Lupus International Collaborating Clinics classification criteria for SLE...