A5017610746- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Rabies epidemiology and control
- Clostridium difficile and Clostridium perfringens research
- Genomics and Phylogenetic Studies
- Antimicrobial Resistance in Staphylococcus
TechnoPhage (Portugal)
2012-2014
In patients with diabetes mellitus, foot infections pose a significant risk. These are complex commonly caused by Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii, all of which potentially susceptible to bacteriophages. Here, we characterized five bacteriophages that had determined previously have antimicrobial wound-healing potential in chronic S. P. A. baumannii infections. Morphological genetic features indicated the were lytic members family Myoviridae or...
Due to their bacterial lytic action, bacteriophage endolysins have recently gained great attention as a potential alternative antibiotics in the combat of Gram-positive pathogenic bacteria, particularly those displaying multidrug resistance. However, large-scale production and purification is frequently impaired due low solubility. In addition, large number appear exhibit reduced efficacy when compared with action during phage infection. Here, we took advantage high solubility two...
Increasing antibiotic resistance of bacterial pathogens has drawn the attention to potential use bacteriophage endolysins as alternative antibacterial agents. Here we have identified, characterized, and studied lytic two endolysins, Lys168 Lys170, from phages infecting Enterococcus faecalis. Lys170 belong cysteine, histidine-dependent amidohydrolases/peptidases (CHAP) amidase-2 protein families, respectively. is quite a unique enterococcal phage endolysin. It shares 95% amino acidic identity...