A5078493089- Malaria Research and Control
- Mosquito-borne diseases and control
- Synthesis and Catalytic Reactions
- Vector-borne infectious diseases
- Computational Drug Discovery Methods
- HIV/AIDS drug development and treatment
- Helminth infection and control
- Phenothiazines and Benzothiazines Synthesis and Activities
- Drug Transport and Resistance Mechanisms
- Trypanosoma species research and implications
- Click Chemistry and Applications
- Invertebrate Immune Response Mechanisms
- Traditional and Medicinal Uses of Annonaceae
- Insect and Pesticide Research
- Venomous Animal Envenomation and Studies
- Parasitic Infections and Diagnostics
- Research on Leishmaniasis Studies
- Coccidia and coccidiosis research
- vaccines and immunoinformatics approaches
University of Delhi
2018-2022
National Institute of Malaria Research
2014-2021
Indian Council of Medical Research
2014-2018
Abstract Malaria still remains a global health problem despite of the availability effective control and treatment measures. In present study, novel series [1, 2,3]‐triazole tethered sulfonamide‐berberine hybrids were synthesized in good yields via Huisgen [3+2] cycloaddition reaction various primary, secondary tertiary sulfonamide based azides with 9‐O‐(propyne)berberine chloride t ‐BuOH:water (1:1) mixture containing catalytic amount sodium ascorbate CuSO 4 .5H 2 O at 90 o C. After...
Malaria remains a global health problem despite availability of effective tools. For malaria elimination, drugs targeting sexual stages Plasmodium falciparum need to be incorporated in treatment regimen along with schizonticidal interrupt transmission. Primaquine is recommended as transmission blocking drug for its effect on mature gametocytes but not extensively utilized because associated safety concerns among glucose-6-phosphate dehydrogenase (G6PD) deficient patients. In present work,...
Abstract A series of benzenesulfonamide‐appended [1,2,3]‐triazole hybrids was synthesized by using [3 + 2] cycloaddition primary, secondary, and tertiary sulfonamide azides with various phenoxymethylacetylenes under click reaction conditions. After structural characterization, the compounds were subjected to in‐silico absorption, distribution, metabolism, excretion toxicity (ADMET) screening evaluate their drug‐likeness other pharmacokinetic parameters. Furthermore, in vitro antiplasmodial...
Abstract Novel 4‐amino‐7‐chloroquinoline‐based 1,2,3‐triazole hybrids were synthesised in good yields by Cu I ‐catalysed Huisgen 1,3‐dipolar cycloaddition reactions of 2‐azido‐ N ‐(7‐chloroquinolin‐4‐ylaminoalkyl)acetamides with various terminal alkynes. These new screened vitro against asexual blood stages the chloroquine‐sensitive 3D7 strain P. falciparum . The most active compounds further and sexual (gametocytes) chloroquine‐resistant RKL‐9 Although all less potent than chloroquine...
Aim & background: Drugs with multiple bioactive moieties have the advantages of modes action and fewer chances drug resistance. In continuation our previous work developing hybrid antimalarials, we present herein synthesis antimalarial activity two different series 7-chloroquinoline-sulfonamide hybrids. Materials methods: The first compounds were synthesized by using p-dodecylbenzenesulfonic acid as a Bronsted catalyst in ethanol. second series' 1,3-dipolar cycloaddition azides alkynes under...
Malaria has remained a global health problem despite the effective control and treatment measures. In backdrop of drug resistance, developing novel hybrid molecules targeting sexual stages (gametocytes) human malaria parasite Plasmodium falciparum is great significance. Recently, chalcone- based polyphenols have generated interest in research community worldwide due to their ease synthesis significant biological activity. The primary objective this study was investigate interaction newly...