A5027625021- Malaria Research and Control
- Genomics and Phylogenetic Studies
- Mosquito-borne diseases and control
- Cancer Genomics and Diagnostics
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Glutathione Transferases and Polymorphisms
- COVID-19 Clinical Research Studies
- Pharmacogenetics and Drug Metabolism
- SARS-CoV-2 and COVID-19 Research
- Vector-borne infectious diseases
- vaccines and immunoinformatics approaches
- GABA and Rice Research
- BRCA gene mutations in cancer
- Plant Disease Resistance and Genetics
- Diverse Scientific Research Studies
- Biofuel production and bioconversion
- COVID-19 and Mental Health
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Metabolomics and Mass Spectrometry Studies
- Protein purification and stability
- Analytical Chemistry and Chromatography
- Corneal Surgery and Treatments
- Microbial Metabolism and Applications
Universiti of Malaysia Sabah
2015-2025
Centro Nacional de Biopreparados (Cuba)
2002
Centro de Ingeniería Genética y Biotecnología
2001
Abstract Biomaterials are natural, synthetic, or hybrid materials, which used in medical devices implants that placed contact with the human biological system to compensate for restore diminished functions of body. The field biomaterials has rapidly developed meet ever-expanding needs healthcare and medicine practices. Advancements science technology have enabled fabrication reengineering into useful implants, such as heart valves, bone plates, hip joints, cardiac pacemakers. Because...
Malaria is a vector borne-parasitic disease transmitted through the bite of infective female Anopheles mosquitoes. Five Plasmodium species have been recognized by World Health Organization (WHO) as causative agents human malaria. Generally, microscopic examination gold standard for routine malaria diagnosis. However, molecular PCR assays in many cases shown improvement on sensitivity and specificity over or other immunochromatographic assays. The present study attempts to screen 207...
Kombucha is sweetened black tea fermented with symbiotic culture of bacteria and yeasts (SCOBY) has been widely consumed for its purported health benefits. The microbial consortium in kombucha dominated by such as Brettanomyces sp. Zygosaccharomyces sp., well acetic acid (AAB), Komagataeibacter Acetobacter However, the source SCOBY substrates used may affect diversity biochemical, flavour kombucha. Identifying population important use undefined starter cultures lead to variable metabolite...
Introduction: The global impact of coronavirus disease 19 (COVID-19), caused by the SARS-CoV-2, has presented unprecedented challenges worldwide. Previous studies have shown an association between angiotensin-converting enzyme 2 (ACE2) single nucleotide polymorphisms (SNPs) and risk COVID-19 severity in different populations. However, it remains unclear Malaysian population. Method: Therefore, this study aims to investigate four ACE2 SNPs (rs2074192, rs2285666, rs714205, rs4240157) In brief,...
Background: Breast cancer is the most common type of affecting Malaysian women. Recent statistics revealed that cumulative probability breast and related deaths in Malaysia higher than countries Southeast Asia. Single nucleotide polymorphisms (SNPs) CYP2E1 (rs6413432 rs3813867), STK15 (rs2273535 rs1047972) XRCC1 (rs1799782 rs25487) have been associated with risk a meta-analysis but any link Asia, including Malaysia, remained to be determined. Hence, we investigated relationship between these...
In high-throughput metabolomic profiling, chromatographic separation is crucial because a well-performed may reduce signal suppression from complex biological matrices and improve the discoverability of low-abundance metabolites. We compared performance pentafluorophenyl (PFP)- octadecylsilane (ODS)-based columns in profiling fluids. Peak resolutions consistencies were acquired using several reversed-phase evaluated. Total extracted ion chromatograms demonstrated that PFP column achieved...
Abstract Background Understanding the genetic diversity of candidate genes for malaria vaccines such as circumsporozoite protein ( csp ) may enhance development treating Plasmodium knowlesi . Hence, aim this study is to investigate non-repeat regions in P. from Malaysian Borneo and Peninsular Malaysia. Methods A total 46 were subjected polymerase chain reaction amplification. The obtained isolates collected different divisions Sabah, Borneo, targeted gene fragments cloned into a commercial...
Background: The XRCC1 protein facilitates various DNA repair pathways; single-nucleotide polymorphisms (SNPs) in this gene are associated with a risk of gastrointestinal cancer (GIC) inconsistent results, but no data have been previously reported for the Sabah, North Borneo, population. We accordingly investigated Arg194Trp and Arg399Gln SNPs terms GIC Sabah. Materials Methods: performed genotyping both 250 patients 572 healthy volunteers using polymerase chain reaction-restriction fragment...
Our study aimed to investigate the association of CYP2E1 C-1019T RsaI and T7678A DraI polymorphisms factors such as age, gender ethnicity risk gastrointestinal cancer (GIC) in Malaysians.Case-control study.Malaysia.520 consented healthy blood donors with no previous GIC record 175 patients GIC.C-1019T genotyping gene; direct sequencing.This reveals that variant c2 allele carrier at least one single nucleotide polymorphism (SNP) significantly increased but significant was found between SNP...
CYP2E1 PstI polymorphism G-1259C (rs3813867) genotype distributions vary significantly among different populations and are associated with both diseases, like cancer, adverse drug effects.To date, there have been limited allele frequencies of this reported in the three major indigenous ethnic groups (KadazanDusun, Bajau, Rungus) Sabah, also known as North Borneo.The aim study was to investigate these peoples Sabah.A total 640 healthy individuals from dominant were recruited for...
The Streptomyces cavourensis strain 2BA6PGT was isolated from sediment the bottom of salt lake Verkhnee Beloe (Buryatia, Russia). This strain's 7,651,223 bp complete genome has a high G + C content 72.1% and consists 7,069 coding sequences 315 subsystems. 16S ribosomal RNA isolate most closely related to NBRC 13026T (98.91% identity), followed by bacillaris ATCC 15855T (95.36%), rhizosphaericola 1AS2cT (94.68%), pluricolorescens JCM 4602T (86.75%). These comparisons were supported pairwise...
Introduction: Obesity is commonly linked up with several life-threatening diseases. This study aims to investigate the association of fatty acid synthase (FASN) rs4246445, rs2229425, rs2228305, and rs2229422 single nucleotide polymorphisms (SNPs) risk overweight obesity in Malaysian population. Methods: Blood samples were collected from 1030 individuals who grouped into normal, overweight, obese categories. biochemistry test lipid profiling performed genomic DNA was extracted. Genotyping...
Background: The COVID-19 pandemic poses an unprecedented public health challenge in Malaysia. impact of varies between countries, including geographically divided states within a country. deadly transmission has taken heavy toll Sabah, Malaysia’s third most populous state, contributing nearly 10% to the recorded national death as 31 December 2022. Although several SARS-CoV-2 genome sequences have been analysed Malaysia, molecular epidemiology data from Sabah focusing on diversity and...
: Breast cancer poses a significant global health challenge, and if current trends persist, the burden of breast is projected to escalate, yielding over 3 million new cases 1 fatalities annually by year 2040. highly heterogeneous disease, presenting spectrum subtypes, each characterized unique clinical behaviors responses treatments. Understanding these subtypes paramount importance in fields oncology personalized medicine. In addition conventional treatments, such as surgery, chemotherapy,...