A5082476183- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Management of metastatic bone disease
- melanin and skin pigmentation
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Bone health and treatments
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Lymphatic System and Diseases
- Ocular Oncology and Treatments
- Cancer Mechanisms and Therapy
- Spinal Hematomas and Complications
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Tumors and Oncological Cases
- Neurofibromatosis and Schwannoma Cases
- Lymphoma Diagnosis and Treatment
- Nutrition and Health in Aging
- Orthopaedic implants and arthroplasty
- Soft tissue tumor case studies
- Musculoskeletal synovial abnormalities and treatments
- Cancer and Skin Lesions
Osaka International Cancer Institute
2009-2025
Osaka University
2014-2024
Discovery Institute
2017-2020
Sanford Burnham Prebys Medical Discovery Institute
2017-2020
Berurando General Hospital
2018-2019
Ashiya University
2018
Kyoto University
2014
Osaka City University
2013
PRMT5 expression in melanoma suppresses inflammation and antigen presentation, suggesting that its inhibition could potentiate immunotherapy.
Linear ubiquitin chains generated by the linear chain assembly complex ( LUBAC ) play an important role in NF ‐κB activation. However, regulation of generation is not well characterized. Here, we identified two deubiquitinating enzymes DUB s), ovarian tumor with linkage specificity OTULIN /Gumby/ FAM 105B) and cylindromatosis CYLD that can cleave polyubiquitin interact via N‐terminal PNG ase/ UBA or UBX PUB domain HOIP , a catalytic subunit . interacts both even unstimulated cells. The...
Although biological resources are essential for basic and preclinical research in the oncological field, those of sarcoma not sufficient rapid development treatment. So far, some cell lines have been established, however, success rate was low established types were frequently biased. Therefore, an efficient culture method is needed to determine various sarcomas. Organoid a 3-dimentional that enables recapitulation tumor microenvironment reported higher than 2-dimentional culture. The purpose...
Angiosarcoma is a rare malignant neoplasm with poor prognosis. A retrospective study was performed to accumulate radiotherapy (RT) data.Data from 17 patients angiosarcoma of the face and scalp (AFS) who were treated definitive RT between January 1999 July 2011 retrospectively analysed. The total radiation dose 70 Gy, fractional doses 2.0-2.5 Gy. Combined RT, chemotherapy using docetaxel alone, recombinant interleukin-2 immunotherapy alone both these in 10, 4 2 patients, respectively. Three...
SHARPIN, an adaptor for the linear ubiquitin chain assembly complex (LUBAC), plays important roles in NF-κB signaling and inflammation. Here, we have demonstrated a LUBAC-independent role SHARPIN regulating melanoma growth. We observed that interacted with PRMT5, type II protein arginine methyltransferase, increased its multiprotein methyltransferase activity. Activated PRMT5 controlled expression of transcription factors SOX10 MITF by SHARPIN-dependent dimethylation inhibition...
Background: Bone metastasis is associated with a poor prognosis. Bone-modifying agents (BMA) are commonly used for the prevention or treatment of skeletal-related events (SRE) in patients bone metastasis; however, whether not BMA improves survival remains unclear. In this study, we investigated was involved post-bone survival. Methods: A total 539 cancer were retrospectively analyzed to identify significant independent factors Results: Among overall population, following cancers had median...
[Purpose] This study aimed to clarify the reliability and validity of a skin elasticity meter for evaluating mechanical properties. [Participants Methods] We conducted prospective observational using data from 35 patients diagnosed with unilateral lower extremity edema caused by cancer-related. evaluated skin's properties (relative parameter; R0, distensibility; R2, gross elasticity; R5, net R6, viscoelasticity; R7, biological elasticity) thigh leg meter. Intra-rater was calculated...
Abstract Background and Objectives The aim of this study is to assess the survival, function, radiographic appearance, modes failure extracorporeal irradiated (ECI) autografts in a long‐term setting. Methods We retrospectively reviewed 87 patients who were treated for bone soft tissue tumors using ECI between 1988 2009. Results 56 had minimum follow‐up 10 years, median period was 16.5 years. reimplantation procedures included 24 osteoarticular grafts, 16 intercalary autograft‐prosthetic...
Abstract Approximately 60–70% of EWSR1 -negative small blue round cell sarcomas harbour a rearrangement CIC , most commonly CIC-DUX4 . sarcoma (CDS) is an aggressive and often fatal high-grade appearing predominantly in children young adults. Although lines their xenograft models are essential tools for basic research development antitumour drugs, few currently exist CDS. We successfully established novel human CDS line designated Kitra-SRS developed orthotopic tumour xenografts nude mice....
There have been few reports on bone metastases (BMs) from esophageal cancer (EC). The aim of the present study was to investigate clinicopathological features and prognostic factors in patients with EC BMs. retrospectively collected data 58 BMs who were treated at our institution between 2007 2016. Patient, tumor BM-associated characteristics analyzed. Kaplan-Meier survival curves constructed analyzed using univariate log-rank test. Multivariate analyses conducted Cox proportional hazards...
Malignant giant-cell tumors are extremely rare bone sarcomas that transform from conventional during long periods of treatment. Owing to their rarity, no further analysis molecular pathogenesis exists, and thus, standard treatment has been established. Recently, organoid culture methods have highlighted for recapturing the tumor microenvironment, we applied succeeded in establishing patient-derived organoids (PDO) sarcomas. This study aimed investigate genomic characteristics our established...
Sarcoma is a rare type of cancer for which new therapeutic agents are required. Ferroptosis nonapoptotic cell death triggered by iron-mediated lipid peroxidation. We found that TFRC, an iron uptake protein, was expressed at higher levels in sarcoma lines than noncancer and carcinoma lines. Glutathione peroxidase 4 (GPX4) protects cells against ferroptosis, its inhibition using RAS-selective lethal 3 (RSL3) had antitumor effect more pronounced lines, particularly synovial cells, compared to...
Abstract Clear cell sarcoma is an aggressive soft tissue and highly resistant to conventional chemotherapy radiation therapy. This devastating disease defined by EWSR 1‐ ATF 1 fusion gene resulting from chromosomal translocation t(12;22)(q13;q12) characterized melanocytic differentiation. A marine‐derived antineoplastic agent, trabectedin, inhibits the growth of myxoid liposarcoma Ewing causing adipogenic differentiation neural differentiation, respectively. In this study, we examined...
Clear cell sarcoma (CCS) is a rare but chemotherapy-resistant and often fatal high-grade soft-tissue (STS) characterized by melanocytic differentiation under control of microphthalmia-associated transcription factor (MITF). Eribulin mesilate (eribulin) mechanistically unique microtubule inhibitor commonly used for STS treatment, particularly liposarcoma leiomyosarcoma. In this study, we examined the antitumor efficacy eribulin on four human CCS lines two mouse xenograft models. inhibited...
The linear ubiquitin chain assembly complex (LUBAC) ligase complex, composed of HOIL-1L-interacting protein (HOIP), heme-oxidized IRP2 ligase-1L (HOIL-1L), and SHANK-associated RH domain protein, specifically generates polyubiquitin chains is involved in NF-κB activation. Lack which drastically reduces the amount HOIP HOIL-1L, causes chronic proliferative dermatitis (cpdm) mice. Impaired activation augmented apoptosis have been implicated pathogenesis cpdm In this study, we found that IFN-γ...
Pelvic osteosarcoma has a poor prognosis compared to osteosarcomas in other locations, and the reasons for this remain unknown. Surgical resection of pelvic is technically demanding often results dysfunction complications. In study, we investigated underlying by comparing it femoral using data from Bone Tumor Registry Japan. We used propensity score analysis determine whether surgical improved its prognosis. demonstrated that had because occurred more elderly, larger tumor size, metastasis...
Calcific myonecrosis is a rare soft tissue condition. The first case was reported in 1960, however, the precise pathophysiology of calcific remains unclear. disease thought to arise from compartment syndrome within confined space resulting necrosis and fibrosis, subsequent repeated intralesional hemorrhage, mass enlargement calcification. Several previous reports have described myonecrosis, which include formation after prolonged period post trauma. Notably, has typically been lower legs...
The number of studies on bone metastasis (BM) from gastric cancer (GC) is currently limited. Therefore, the aim present study was to investigate characteristics, skeletal‑related events (SREs) and prognosis GC in patients with BMs. Data 60 BMs were retrospectively retrieved patient‑, tumor‑ BM‑related characteristics analyzed. Kaplan‑Meier survival curves analyzed using univariate log‑rank test. Multivariate analyses conducted Cox proportional hazards model. median patient age 63.5 years...
Sarculator is a validated nomogram designed to predict overall survival (OS) in extremity soft tissue sarcoma (STS). Inflammation plays critical role cancer development and progression. There were no reports which investigated the relationship between inflammation. A total of 217 patients with STS included. The Sarculator-predicted 10-year probability OS (pr-OS) was stratified into two subgroups: lower risk (10-year pr-OS ≥ 60%) higher < 60%). modified Glasgow prognostic score (mGPS) varied...
Undifferentiated pleomorphic sarcoma (UPS) is a high‑grade, aggressive soft tissue (STS) with poor prognosis, and no definitive or effective treatment currently available for it. Pazopanib, an orally multiple tyrosine kinase inhibitor, has been approved the of advanced STS. The present study documents case 51‑year‑old man UPS coamplification platelet‑derived growth factor receptor A (<em>PDGFRA</em>), vascular endothelial 2 (<em>VEGFR2</em>) stem cell (<em>KIT</em>) genes. patient exhibited...
Skin conditions in patients with lymphedema have been identified according to changes skin mechanical properties. The elasticity meter is a non-invasive tool for measuring the properties of skin; however, its potential use has received little attention. This review aimed provide an overview studies using meter.