A5100710728- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Viral gastroenteritis research and epidemiology
- Nosocomial Infections in ICU
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Rare-earth and actinide compounds
- Gastric Cancer Management and Outcomes
- Veterinary medicine and infectious diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Heat shock proteins research
- Breast Cancer Treatment Studies
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Orthopaedic implants and arthroplasty
- Hemophilia Treatment and Research
- Pharmacological Effects of Natural Compounds
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Sulfur Compounds in Biology
- NF-κB Signaling Pathways
- Facial Nerve Paralysis Treatment and Research
Yonsei University
2015-2024
Korea Foundation for Max Planck POSTECH
2024
Severance Hospital
2013-2024
Kangwon National University
2024
University of Pittsburgh
2024
Seoul Medical Center
2020-2024
Kyung Hee University
2023
Korea University
2023
Myongji Hospital
2023
Hanyang University
2023
PRMT5 expression in melanoma suppresses inflammation and antigen presentation, suggesting that its inhibition could potentiate immunotherapy.
Abstract Background High mobility group box-1 (HMGB1) is a newly recognized factor regulating cancer cell tumorigenesis, expansion and invasion. We investigated the correlation between serum HMGB1 levels clinical pathologic features of gastric evaluated validity as potential biomarker for early diagnosis cancer. Methods A total 227 subjects were classified into 5 disease groups according to 'gastritis-dysplasia-carcinoma' sequence carcinogenesis their analyzed by an enzyme-linked...
The reported incidence of facial weakness immediately after parotid tumor surgery ranges from 14 to 65%. purpose this study was evaluate the postoperative related parotidectomy with use preoperative computed tomography (CT), intraoperative nerve monitoring, and surgical magnification. Also, we sought elucidate additional information about risk factors for in surgery, particularly focusing on subsites.We retrospectively reviewed 794 cases benign malignant tumors arising gland (2009-2016)....
Heejung Kim, M.D., Seok Hoon Jeong, Kyoung Ho Roh, Seong Geun Hong, Jong Wan Myung-Geun Shin, Mi-Na Hee Bong Young Uh, Hyukmin Lee, Kyungwon M.D.. Korean J Lab Med 2010;30:491-7. https://doi.org/10.3343/kjlm.2010.30.5.491
The production of cytokines such as type I interferon (IFN) is an essential component innate immunity. Insufficient amounts lead to host sensitivity infection, whereas abundant cytokine can inflammation. A tight regulation is, thus, for homeostasis the immune system. IFN-α during RNA virus infection mediated by master transcription factor IRF7, which activated upon ubiquitination TRAF6 and phosphorylation IKKϵ TBK1 kinases. We found that Fas-associated death domain (FADD), first described...
Abstract Background and Objectives Skin sparing mastectomy (SSM) has been demonstrated as an oncologically safe procedure for early breast cancer in several studies. But few studies concerned the safety of SSM patients with locally advanced cancer; therefore, its these is less clear. The purpose this study to examine oncological followed by immediate reconstruction cancer. Methods We retrospectively analyzed 897 who underwent stage IIB (T3N0)‐III between 1996 2005. Of 897, 87 (n = 73) or...
Byoungrak An, Ph.D., Byung Soo Moon, M.D., Heejung Kim, Hyun Chul Lim, Yong Chan Lee, Gyusang Sa-Hyun Min Park, B.S., and Jong Bae Ph.D.. Ann Lab Med 2013;33:415-9. https://doi.org/10.3343/alm.2013.33.6.415
ABSTRACT The diarrheal pathogen Clostridium difficile consists of at least six distinct evolutionary lineages. RT017 lineage is anomalous, as strains only express toxin B, compared to from other lineages that produce toxins A and B and, occasionally, binary toxin. Historically, initially was reported in Asia but now has been worldwide. We used whole-genome sequencing phylogenetic analysis investigate the patterns global spread population structure 277 isolates animal human origins...
Omicron variant viruses spread rapidly, even in individuals with high vaccination rates. This study aimed to determine the utility of antibody against spike protein level as a predictor disease course coronavirus 2019 (COVID-19) vaccinated patients.Between December 11, 2021, and February 10, 2022, we performed prospective observational cohort South Korea, which included patients infected Delta variants. A multivariable logistic regression analysis association between levels outcomes was...
We investigated a molecular mechanism underlying quercetin-mediated amelioration of colonic mucosal injury and analyzed chemical structure contributing to the quercetin9s effect. Quercetin up-regulated vascular endothelial growth factor (VEGF), an ulcer healing factor, not only in colon epithelial cell lines but also inflamed tissue. VEGF derived from quercetin-treated cells promoted tube formation. The induction was dependent on hypoxia-inducible factor-1 (HIF-1) activation. delayed HIF-1α...
Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% A negative (A(-) B(+)). The binary gene was detected in nine isolates. higher fluoroquinolone resistance of A(-) B(+) strains may contribute to the increase these strains. Toxin detection alone underdiagnose C. difficile-associated disease.
The aims of this study were to investigate any change in PCR ribotypes and determine the antimicrobial resistance common over a 10-year period tertiary care hospital. We conducted ribotyping, susceptibility testing DNA gyrase sequencing identify changes 1407 Clostridium difficile non-duplicated isolates obtained between 2000 2009. A total 74 different found. most prevalent ribotype was 001 (26.1 %). prevalence 017 17 % that 014/020 9.6 %. Ribotyping showed decreased 017, 018 increased 10...
Clostridium difficile is a significant nosocomial and community-acquired pathogen, the leading cause of antibiotic-induced diarrhea associated with high morbidity mortality. Given that treatment outcome depends on severity C. infection (CDI), we aimed to establish an efficient method assessing severity, focused stool biomarker fecal calprotectin (FC). FC directly reflects intestinal inflammation status patient, can aid in interpreting current guidelines, which requires integration indirect...
Catechins, components of green tea, reduce the incidence cardiovascular diseases such as atherosclerosis. Angiotensin II (Ang II) is highly implicated in proliferation vascular smooth muscle cells (VSMC), resulting The acting mechanisms catechins remain to be defined VSMC induced by Ang II. Here we report that catechin, epicatechin (EC), epicatechingallate (ECG) or epigallocatechingallate (EGCG) significantly inhibits II-induced [3H]thymidine incorporation into primary cultured rat aortic...
Clostridium difficile (C. difficile) is a common causative agent of pseudomembranous colitis (PMC). C. difficile-associated diarrhea (CDAD) ranges from mild to life threatening PMC. Recently, highly virulent strain polymerase chain reaction ribotype 027 was found in North America, Europe, and Japan. A 52-yr-old woman with anti-tuberculosis medication neurogenic bladder due traffic accident experienced five episodes PMC after taking antibiotics for pneumonia along septic shock acute renal...
Infection with Clostridium difficile is a growing concern because of the increasing prevalence and spread nosocomial infections. Emergence hypervirulent 027/NAP1/BI strain also notable. Existing diagnostic methods have low sensitivity or are time-consuming. Therefore, establishing rapid accurate microbiological assay needed. We evaluated Xpert C. (Xpert CD assay; Cepheid, USA) to detect toxigenic difficile. This real-time multiplex PCR that can be used strains differentiate presumptive...
SHARPIN, an adaptor for the linear ubiquitin chain assembly complex (LUBAC), plays important roles in NF-κB signaling and inflammation. Here, we have demonstrated a LUBAC-independent role SHARPIN regulating melanoma growth. We observed that interacted with PRMT5, type II protein arginine methyltransferase, increased its multiprotein methyltransferase activity. Activated PRMT5 controlled expression of transcription factors SOX10 MITF by SHARPIN-dependent dimethylation inhibition...
The purpose of the current in silico planning study is to compare radiation doses whole-breast irradiation (WBI) and plus regional lymph node (WBI+RNI) administered nodes (RLN) pN1 breast cancer. Twenty-four participating institutions were asked create plans WBI WBI+RNI for two dummy cases. To target coverage between participants, an isodose line equal 90% prescribed dose was converted contour (contour90% iso). relative nodal (RND) obtained using ratio RLN dose. Fleiss’s kappa values which...