A5040401417- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Immune cells in cancer
- Cardiomyopathy and Myosin Studies
- Immune Cell Function and Interaction
- Turfgrass Adaptation and Management
- Economic and Social Issues
- Bioenergy crop production and management
- Heat shock proteins research
- Hedgehog Signaling Pathway Studies
- Thermal Regulation in Medicine
- Signaling Pathways in Disease
- Inflammation biomarkers and pathways
- Botany and Plant Ecology Studies
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Cardiovascular Effects of Exercise
- Analytical Methods in Pharmaceuticals
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiac Structural Anomalies and Repair
- Cancer-related Molecular Pathways
- Atrial Fibrillation Management and Outcomes
Leipzig University
2015-2025
Martin Luther University Halle-Wittenberg
2014-2021
B. Braun (Netherlands)
2019
Institute of Pathology Celle
2019
University of Bonn
2017
Technische Universität Dresden
1998
Abstract Obesity is associated with chronic low-grade inflammation of adipose tissue (AT) and an increase AT macrophages (ATMs) that linked to the onset type 2 diabetes. We have recently shown focal sites around dying adipocytes, so-called crown-like structures, exhibit a unique microenvironment for macrophage proliferation. Interestingly, locally proliferating were not classically activated (M1), but they exhibited rather alternatively (M2) immune phenotype. In this study, we established...
Human adipose depots are functionally distinct. Yet, recent single-nucleus RNA sequencing (snRNA-seq) analyses largely uncovered overlapping or similar cell-type landscapes. We hypothesized that adipocyte subtypes, differentiation trajectories and/or intercellular communication patterns could illuminate this depot similarity–difference gap. For this, we performed snRNA-seq of human subcutaneous visceral tissues (five ten samples, respectively). Of 27,665 nuclei in both depots, most were...
Obesity is associated with chronic low-grade inflammation of adipose tissue (AT) and an increase AT macrophages (ATMs) that linked to the onset type 2 diabetes. We have recently shown neutralization interleukin (IL)-6 in obese organ cultures inhibits proliferation ATMs, which occurs preferentially alternatively activated macrophage phenotype. In this study, we investigated biology metabolic phenotype mice myeloid cell-specific IL-6Rα deficiency (Il6ra Δmyel) after normal chow 20 weeks...
Obesity is frequently associated with a chronic low-grade inflammation within adipose tissue (AT). Although classical signs of are missing in AT inflammation, there significant increase macrophages and, to lesser extent, other immune cells, such as T B mast and neutrophils. The spatial temporal activation these cells well their accumulation the seem be tightly linked so-called crown-like structures (CLS). CLS accumulations (ATMs) around dead adipocytes thought reflect scavenger response. At...
Obesity is associated with chronic low-grade inflammation of visceral adipose tissue (AT) characterized by an increasing number AT macrophages (ATMs) and linked to type 2 diabetes. histologically indicated the formation so-called crown-like structures, as ATMs accumulate around dying adipocytes, occurrence multinucleated giant cells (MGCs). However, date, function MGCs in obesity unknown. Therefore, aim this study was characterize unravel these cells. We demonstrated that occurred obese...
The z-disc is a structural component at the lateral borders of sarcomere and important for mechanical stability contractility both cardiac skeletal muscles. Of note, sarcomeric also represents nodal point in cardiomyocyte function signaling. Mutations numerous proteins are associated with cardiomyopathies muscle diseases. To identify additional that might contribute to disease, we employed an silico screen cardiac-enriched cDNAs. This yielded previously uncharacterized protein named...
IL-4 receptor signaling is supposed to play a major role in anti-inflammatory polarization and proliferation of adipose tissue macrophages. In this study, we examined the metabolic inflammatory phenotype C57BL/6J mice (IIl4ra) with LysM-dependent knockout (IIl4ra Δmyel) α-chain (IL-4Rα), mandatory component IL-13, on chow high-fat diet. Lean IIl4ra Δmyel showed decreased insulin sensitivity, no divergent macrophage polarization, but an increased percentage CD8+ T cells visceral tissue. After...
Abstract Obesity is frequently associated with a chronic low‐grade inflammation in the adipose tissue (AT) and impaired glucose homeostasis. Adipose macrophages (ATMs) have been shown to accumulate inflamed AT either by means of recruitment from blood or local proliferation. ATM proliferation activation can be stimulated TH2 cytokines, such as IL‐4 IL‐13, suggesting involvement CD4‐positive T cells activation. Furthermore, several studies alterations metabolism. Therefore, we sought examine...
The co-chaperone BAG3 (Bcl-2 associated athanogene 3) is strongly expressed in cross-striated muscles and plays a key role the turnover of muscle-proteins as member CASA (chaperone-assisted selected autophagy) complex. An amino acid exchange (P209L) human gene, caused by single base mutation, gives rise to severe dominant childhood muscular dystrophy, restrictive cardiomyopathy, respiratory insufficiency. To get deeper insights into pathophysiological mechanisms disease, we generated...
Obesity is associated with a chronic low-grade inflammation in visceral adipose tissue (AT) characterized by an increasing number of macrophages (ATMs) and linked to type 2 diabetes. AT histologically indicated the formation so-called crown-like structures (CLS), as accumulation ATMs around dying adipocytes, occurrence multi-nucleated giant cells (MGCs). However date, function MGCs obesity unknown. Hence, aim this study was characterize unravel these cells. <p>We demonstrate that occur...
Obesity is associated with a chronic low-grade inflammation in visceral adipose tissue (AT) characterized by an increasing number of macrophages (ATMs) and linked to type 2 diabetes. AT histologically indicated the formation so-called crown-like structures (CLS), as accumulation ATMs around dying adipocytes, occurrence multi-nucleated giant cells (MGCs). However date, function MGCs obesity unknown. Hence, aim this study was characterize unravel these cells. <p>We demonstrate that occur...