A5048374805- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
- Colorectal Cancer Screening and Detection
- Primary Care and Health Outcomes
- Patient Safety and Medication Errors
- Sarcoma Diagnosis and Treatment
- Patient Satisfaction in Healthcare
- Global Health Workforce Issues
- Antibiotic Use and Resistance
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Global Health Care Issues
- Health Sciences Research and Education
- Diversity and Career in Medicine
- Cancer survivorship and care
- Augmented Reality Applications
- Patient Dignity and Privacy
- Maternal and fetal healthcare
- Pain Management and Placebo Effect
- Childhood Cancer Survivors' Quality of Life
- Healthcare Policy and Management
- Global Cancer Incidence and Screening
University of Exeter
2017-2025
The University of Melbourne
2024
Sandwell General Hospital
2024
Heart Rhythm Society
2024
Neuroscience Research Australia
2024
Peninsula College of Medicine and Dentistry
2017-2023
Queen Mary University of London
2023
University of Leeds
2023
NHS Blood and Transplant
2023
Glasgow Royal Infirmary
2023
We have sequenced miRNA libraries from human embryonic, neural and foetal mesenchymal stem cells. report that the majority of genes encode mature isomers vary in size by one or more bases at 3′ and/or 5′ end miRNA. Northern blotting for individual miRNAs showed proportions isomiRs expressed a single gene often differ between cell tissue types. IsomiRs were readily co-immunoprecipitated with Argonaute proteins vivo active luciferase assays, indicating they are functional. Bioinformatics...
BACKGROUND The Demoralization Scale (DS) was initially validated in 2004 to enable the measurement of demoralization patients with advanced cancer. Subsequent shortcomings indicated need for psychometric strengthening. Here, authors report on refinement and revalidation DS form DS‐II, specifically reporting scale's internal validity. METHODS Patients cancer or other progressive diseases who were receiving palliative care (n = 211) completed a revised version 24‐item measure symptom burden...
<h3>Importance</h3> Inadequate management of elevated blood pressure (BP) is a significant contributing factor to maternal deaths. Self-monitoring BP in the general population has been shown improve diagnosis and hypertension; however, little known about its use pregnancy. <h3>Objective</h3> To determine whether self-monitoring higher-risk pregnancies leads earlier detection pregnancy hypertension. <h3>Design, Setting, Participants</h3> Unblinded, randomized clinical trial that included 2441...
Inadequate management of elevated blood pressure is a significant contributing factor to maternal deaths. The role self-monitoring in pregnancy improving clinical outcomes for the pregnant individual and infant unclear.To evaluate effect self-monitoring, compared with usual care alone, on control other related outcomes, individuals hypertension.Unblinded, randomized trial that recruited between November 2018 September 2019 15 hospital maternity units England. Individuals chronic hypertension...
Background: Autistic people can face remediable barriers and difficulties with driving, yet there is no consensus around effective support methods. This review therefore sought to evaluate the implementation effectiveness of driving interventions for autistic people.Methods: We conducted a multimethod, participatory synthesis evidence. Studies were obtained from Medline, Social Policy Practice, ASSIA, PsycINFO, CINAHL, ERIC, Scopus Epistemonikos. Data extracted those that implemented...
Abstract In mouse models of acute motor axonal neuropathy, anti‐ganglioside antibodies (AGAbs) bind to axons, notably the distal nerve, and activate complement cascade. While activation is well studied in this model, role inflammatory cells unknown. Herein we aimed investigate contribution phagocytic including macrophages, neutrophils perisynaptic Schwann (pSCs) nerve pathology. To observe this, first created a subacute injury model sufficient duration allow cell recruitment. Mice were...
Background UK general practice faces a workforce crisis, with practitioner (GP) shortages, organisational change, substantial pressures across the whole health-care system and an ageing population increasingly complex health needs. GPs require lengthy training, so retaining existing is urgent important. Objectives (1) To identify key policies strategies that might (i) facilitate retention of experienced in direct patient care or (ii) support return following career break. (2) consider...
Background Mental health problems are common among children and young people in the UK. Some from ethnic minority backgrounds experience mental different ways those non-ethnic backgrounds. Furthermore, often greater difficulties accessing support variable levels of engagement with services, may prefer to their white British peers. Objective To describe nature scope qualitative research about experiences seeking or obtaining care for problems. Data sources We searched seven bibliographic...
Abstract Background A systematic review of economic evaluations for lung cancer identified no models the UK setting based on disease natural history. We first sought to develop a new model history population screening, then explore cost-effectiveness multiple alternative potential programmes. Methods An individual patient (ENaBL) was constructed in MS Excel® and calibrated against data from US National Lung Screening Trial. Costs were taken Cancer Trial took perspective NHS PSS. Simulants...
Background: Cognitive-motor step training can improve stepping, balance and mobility in people with multiple sclerosis (MS), but effectiveness preventing falls has not been demonstrated. Objectives: This multisite randomised controlled trial aimed to determine whether 6 months of home-based exergame could reduce associated risk factors compared usual care MS. Methods: In total, 461 MS aged 22–81 years were randomly allocated (control) or unsupervised (120 minutes/week) for months. The...