A5101927190- Heat shock proteins research
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
The University of Sydney
2020
Children's Medical Research Institute
2009-2020
High levels of the cold shock protein Y-box-binding protein-1, YB-1, are tightly correlated with increased cell proliferation and progression. However, precise mechanism by which YB-1 regulates is unknown. Here, we found that depletion in several cancer lines immortalized fibroblasts resulted cytokinesis failure consequent multinucleation. Rescue experiments indicated was required for completion cytokinesis. Using confocal imaging essential orchestrating spatio-temporal distribution...
ABSTRACT High levels of the cold shock protein Y-box-binding protein-1, YB-1, are tightly correlated with increased cell proliferation and cancer progression. However, precise mechanism by which YB-1 regulates is unknown. Here, we found that depletion in several lines resulted cytokinesis failure, multinucleation an increase G 1 transit time. Rescue experiments indicated was required for completion cytokinesis. Using confocal imaging cells undergoing both vitro zebrafish embryos, critical...