A5080763107- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Fetal and Pediatric Neurological Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Behavioral and Psychological Studies
- Attention Deficit Hyperactivity Disorder
- Retinal Development and Disorders
- Child and Animal Learning Development
- Health, Environment, Cognitive Aging
- Psychology of Development and Education
- Nicotinic Acetylcholine Receptors Study
- Genomic variations and chromosomal abnormalities
- Memory and Neural Mechanisms
- Neonatal and fetal brain pathology
- Neuroscience and Neural Engineering
- Neurobiology of Language and Bilingualism
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Neurogenesis and neuroplasticity mechanisms
- Tactile and Sensory Interactions
University of Florida
2015-2025
Center for Neurosciences
2017
Yale University
2017
University of British Columbia
2017
Universidad de Salamanca
2017
Hussman Institute for Autism
2017
University of California, San Francisco
2017
University of California, Los Angeles
2017
University of California, Davis
2017
Abstract Neurite orientation dispersion and density imaging (NODDI) uses a three‐compartment model to probe brain tissue microstructure, whereas free‐water (FW) models two‐compartments. It is unknown if NODDI detects more disease‐specific effects related neurodegeneration in Parkinson's disease (PD) atypical Parkinsonism. We acquired multi‐ single‐shell diffusion at 3 Tesla across two sites. (using multi‐shell; isotropic volume [Viso]; intracellular [Vic]; [ODI]) FW single‐shell; FW;...
Abstract Background Restricted repetitive behavior (RRB) is one of two behavioral domains required for the diagnosis autism spectrum disorder (ASD). Neuroimaging widely used to study brain alterations associated with ASD and domain social communication deficits, but there has been less work regarding linked RRB. Methods We utilized neuroimaging data from National Institute Mental Health Data Archive assess basal ganglia cerebellum structure in a cohort children adolescents compared typically...
Autism spectrum disorder (ASD) is a lifelong condition that profoundly impacts health, independence, and quality of life. However, research on brain aging in autistic adults limited, microstructural variations white gray matter remain poorly understood. To address this critical gap, we assessed novel diffusion MRI (dMRI) biomarkers, free water, water corrected fractional anisotropy (fwcFA), mean diffusivity (fwcMD) across 32 transcallosal tracts their corresponding homotopic grey...
Advanced diffusion imaging which accounts for complex tissue properties, such as crossing fibers and extracellular fluid, may detect longitudinal changes in widespread pathology atypical Parkinsonian syndromes. We implemented fixel-based analysis, Neurite Orientation Density Imaging (NODDI), free-water Parkinson's disease (PD), multiple system atrophy (MSAp), progressive supranuclear palsy (PSP), controls longitudinally over one year. Further, we used these three advanced techniques to...
Abstract Objective measures of disease progression are critically needed in research on Parkinson’s (PD) and atypical Parkinsonism but may be hindered by both practicality cost. The Purdue Pegboard Test (PPT) is objective, has high test-retest reliability, a low goals this study were to determine: (1) longitudinal changes PPT multisite cohort patients with PD, Parkinsonism, healthy controls; (2) whether performance reflects brain pathology revealed neuroimaging; (3) quantify kinematic...
Abstract Training cognitive skills, such as remembering a list of words or navigating new city, has important implications for both health and disease. Yet, understanding what brain changes underlie the acquisition complex skills remains unresolved. Here, we developed validated intensive multiweek interventions in which participants were randomly assigned training either navigation verbal memory. Healthy young (N=75) underwent structural functional imaging prior to following training. Based...
DYT1 dystonia is an early onset, generalized form of isolated characterized by sustained involuntary muscle co-contraction, leading to abnormal movements and postures. It the most common hereditary primary dystonia, caused a trinucleotide GAG deletion in gene, which encodes TorsinA protein. Recent studies conceptualized as functional network disorder involving basal ganglia, thalamus, cortex cerebellum. However, how dysfunction specific cell types affects connectivity dystonia-related...
Ritonavir, identified by a DYT1 dystonia in vitro drug screen, corrects neuronal firing response and white matter deficits the mouse brain.
Sensorimotor processing alterations are a growing focus in the assessment and treatment of Autism Spectrum Disorders (ASD). The rotational vestibulo‐ocular reflex (rVOR), which functions to maintain stable vision during head movements, is sensorimotor system that may be useful understanding such their underlying neurobiology. In this study, we assessed post‐rotary nystagmus elicited by continuous whole body rotation among children with high‐functioning ASD typically developing children....
Objective This study addresses an important problem in neurology, distinguishing tremor and ataxia using quantitative methods. Specifically, we aimed to quantitatively separate dysmetria, a cardinal sign of ataxia, from essential (ET). Methods In Experiment 1, compared 19 participants diagnosed with ET undergoing thalamic deep brain stimulation (DBS; DBS ) healthy controls (HC). We quantified during postural tasks accelerometry dysmetria fast, reverse‐at‐target goal‐directed movements. To...
Restricted, repetitive behaviors are common symptoms in neurodevelopmental disorders including autism spectrum disorder. Despite being associated with poor developmental outcomes, remain poorly understood and have limited treatment options. Environmental enrichment attenuates the development of behaviors, but exact mechanisms obscure. Using C58 mouse model behavior, we performed diffusion tensor imaging to examine microstructural alterations behavior its attenuation by environmental...
Dystonia is a neurological movement disorder characterized by repetitive, unintentional movements and disabling postures that result from sustained or intermittent muscle contractions. The basal ganglia cerebellum have received substantial focus in studying DYT1 dystonia. It remains unclear how cell-specific ∆GAG mutation of torsinA within specific cells the affects motor performance, somatosensory network connectivity, microstructure. In order to achieve this goal, we generated two...
<strong>Background:</strong> Deep brain stimulation (DBS) of the ventralis intermedius (VIM) nucleus thalamus has been successful in mitigating upper limb tremor, but effect on gait and balance performance is unclear. Here, we aim to examine effectiveness VIM DBS stride length variability, sway path length, task-relevant tremor various body segments essential (ET). <strong>Methods:</strong> Seventeen ET individuals treated with (ET DBS) 17 age-and sex-matched healthy controls (HC) performed...
<title>Abstract</title> <bold>Background: </bold>Autism spectrum disorder (ASD) has long been recognized as a lifelong condition, but brain aging studies in autistic adults aged >30 years are limited. Free water, novel imaging marker derived from diffusion MRI (dMRI), shown promise differentiating typical and pathological monitoring degeneration. We aimed to examine free water corrected dMRI measures assess white gray matter microstructure their associations with age adults....
Restricted repetitive behaviors (RRB) encompass a variety of inflexible behaviors, which are diagnostic for autism spectrum disorder (ASD). Despite being requisite criteria, the neurocircuitry these remains poorly understood, limiting treatment development. Studies in translational animal models show environmental enrichment (EE) reduces expression RRB, although underlying mechanisms largely unknown. This study used functional magnetic resonance imaging to identify connectivity alterations...