A5063973193- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- Lymphoma Diagnosis and Treatment
- Urticaria and Related Conditions
- CAR-T cell therapy research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Viral-associated cancers and disorders
- Fungal Infections and Studies
- CNS Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Nail Diseases and Treatments
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders
- Cancer and Skin Lesions
- Vasculitis and related conditions
- T-cell and Retrovirus Studies
- Skin and Cellular Biology Research
- Hidradenitis Suppurativa and Treatments
- Asthma and respiratory diseases
- Cutaneous Melanoma Detection and Management
- Histiocytic Disorders and Treatments
- Psoriasis: Treatment and Pathogenesis
- Platelet Disorders and Treatments
- Hemoglobin structure and function
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2012-2021
University of Milan
2010-2021
Ospedale Maggiore
2007-2021
University of Milano-Bicocca
2011
Institute of Dermatology
2009-2011
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2010
Pyoderma gangrenosum (PG) and Sweet's syndrome (SS) are two inflammatory skin diseases presenting with painful ulcers erythematous plaques, respectively; both disorders have a debilitating clinical behaviour PG is potentially life-threatening. Recently, SS been included among the autoinflammatory diseases, which characterized by recurrent episodes of sterile inflammation, without circulating autoantibodies autoreactive T cells. However, an pattern clearly supporting this inclusion has never...
Pyoderma gangrenosum (PG) is a rare, immune-mediated inflammatory skin disease presenting with painful ulcers having undermined edges. Less commonly, bullous and vegetative variants exist. Histology consists of neutrophil-rich dermal infiltrate. We characterized immunohistochemically the infiltrate in different PG another neutrophilic dermatosis as Sweet's syndrome. studied 21 patients PG, eight syndrome 20 controls, evaluating immunoreactivity for cell markers (CD3, CD163 myeloperoxidase),...
The association of pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH) has recently been described suggested to be a new entity within the spectrum autoinflammatory syndromes, which are characterized by recurrent episodes sterile inflammation, without circulating autoantibodies autoreactive T-cells. We conducted an observational study on 5 patients with PASH syndrome, analyzing their clinical features, genetic profile 10 genes already known involved in diseases (AIDs), cytokine...
Although several cases of chronic urticaria (CU) are currently regarded as autoimmune in origin, associated with histamine-releasing autoantibodies, an activation blood coagulation via tissue factor (TF) and a strong expression TF lesional skin have been described. Eosinophils, which involved CU lesions, recently demonstrated the major source human blood. We assessed whether eosinophils cellular lesions.Twenty patients severe were studied. Skin biopsy specimens taken from wheals. The control...
Linear IgA bullous dermatosis (LABD) is a rare autoimmune subepithelial vesiculobullous disease due to autoantibodies directed against different antigens of the basement membrane zone (BMZ) skin and/or mucosae. It affects mainly preschool-aged children and adults, with only few studies on large series. The aim this study was assess possible differences between adults regarding clinical presentation, immunopathologic features, management course disease. A retrospective review 38 LABD...
Bullous pemphigoid (BP) is a blistering skin disease caused by autoantibodies to hemidesmosomal proteins, with eosinophils participating in blister formation. Eosinophils are source of tissue factor (TF), an initiator blood coagulation.To evaluate the local and systemic activation coagulation BP.We studied 20 patients active BP (eight re-evaluated during remission) 40 controls. The markers prothrombin fragment F1+2 d-dimer were measured plasma all subjects both fluid BP. TF was evaluated...
Although chronic urticaria (CU) is often regarded as autoimmune in nature, only less than 50% of sera from CU patients contain histamine-releasing autoantibodies. This suggests that other factors may contribute to its pathogenesis. We evaluated the possible involvement vascular endothelial growth factor (VEGF), one major mediators permeability, CU.Eighty consecutive adult with and 53 healthy subjects were studied. VEGF prothrombin fragment F(1+2) measured by enzyme immunoassays. Autologous...
Abstract Borrelia burgdorferi has been variably associated with different forms of primary cutaneous lymphoma. Differences in prevalence rates among reported studies could be a result geographic variability or heterogeneity the molecular approaches that have employed. In present study, we investigated sensu lato DNA diagnostic tissue samples from fresh biopsies 98 lymphomas and 19 normal skin controls. Three polymerase chain reaction (PCR) protocols targeting hbb, flagellin, Osp-A genes were...
Primary cutaneous CD4+ small-/medium-sized pleomorphic T-cell lymphoma (CD4+ PCSM-TCL) is a rare lymphoproliferative disorder with favorable prognosis. Distinguishing it from other lymphomas often challenge.We retrospectively collected CD4+PCSM-TCL cases two centers (MD Anderson Cancer Center, USA and University of Milan, Italy) evaluated their clinicopathological features. Array-comparative genomic hybridization (aCGH) analysis was performed on 11 cases.A total 62 patients were identified....
Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECyTCL) is a rare variant of with an clinical course and very poor prognosis. Until now, neither systematic characterization genetic alterations driving pcAECyTCL has been performed, nor effective therapeutic regimes for patients have defined. Here, we present the first highresolution by using wholegenome RNA sequencing. Our study provides comprehensive description (i.e., genomic rearrangements, copy number...
<i>Background:</i> Pemphigus is a severe blistering disorder caused by autoantibodies to desmogleins 1 and 3. Because some patients with pemphigus never enter into remission, new immunosuppressants are warranted. Rituximab chimeric monoclonal antibody binding the CD20 antigen on B cells, which proved be effective in recalcitrant pemphigus. <i>Objectives:</i> To evaluate efficacy safety of rituximab refractory investigate its effects autoantibody profile....
Bullous pemphigoid (BP) is a skin disease caused by autoantibodies to hemidesmosomal proteins BP180 and BP230, with eosinophils participating in blister formation. Tissue factor (TF), the initiator of coagulation, embodied within eosinophil granules exposed upon activation. We evaluated coagulation activation patients BP (63), chronic urticaria (CU; 20), atopic dermatitis (AD; 14), cutaneous drug reactions (CDRs; six), psoriasis (20), herpetiformis (DH; four) primary T cell lymphoma (CTCL;...
Amicrobial pustulosis of the folds (APF) is a rare cutaneous disease characterized by relapsing sterile pustules frequently associated with autoimmune disorders. Although APF pathophysiology still undefined, scattered reports suggest involvement neutrophils. The aim present study to evaluate role skin inflammatory infiltrate, selected multifunctional cytokines and effectors tissue damage in other neutrophilic dermatoses. We studied, immunohistochemical methods, cell markers (CD3, CD163,...
Journal Article Diagnosis and disease severity assessment of epidermolysis bullosa acquisita by ELISA for anti‐type VII collagen autoantibodies: an Italian multicentre study Get access A.V. Marzano, Marzano Unità di Dermatologia, Dipartimento Fisiopatologia e dei Trapianti, Università degli Studi Milano, Fondazione IRCCS Ca' Granda – Ospedale Maggiore Policlinico, Via Pace 9, 20122, Italy Angelo V. Marzano. E‐mail: angelovalerio.marzano@policlinico.mi.it Search other works this author on:...
Cutaneous metastases represent 2% of all skin tumours. Their recognition can be challenging, as they may present with different clinical features, consequent frequent delay and failure in diagnosis. To review our series cutaneous metastatic lesions, analyse their frequency according to patient gender, histotype, localization the primary tumour, site metastasis, correlate this data clinicopathological parameters. We conducted a retrospective cases from visceral neoplasms diagnosed...
Primary cutaneous acral CD8 + T‐cell lymphoma (acral TCL ) is a new provisional entity characterized by skin lesions and an indolent course. We describe extraordinary case relapsed nodules with cytotoxic infiltrates on the left ear. After 35 years, spread to other sites, mass same histological features as appeared nose. Multiple courses of chemotherapy led stable disease. Histological examinations carried out at different times showed gradual transformation neoplastic cells, increased...
Summary The main autoimmune blistering skin disorders are pemphigus vulgaris (PV) and bullous pemphigoid (BP). They differ in the inflammatory infiltrate, which is more intense BP. Inflammation known to activate coagulation several disorders. Local systemic activation of was evaluated BP PV. We studied 20 patients (10 active 10 remittent), 23 PV (13 remittent) healthy subjects. markers prothrombin fragment F1+2 D-dimer were measured by enzyme-immunoassays plasma. presence tissue factor (TF),...
Origin of basal cell carcinoma (BCC) is still unclear. We studied the cytokeratin (CK) profile in BCC using monoclonal antibodies against 12 CKs to further investigate suggested origin tumor from follicular matrix cells or outer root sheath and determine if subtypes can be identified on basis their CK profiles. Cases pilomatricoma samples fetal skin served as controls establish matrical developing follicles during intrauterine life, that epidermis cutaneous adnexa adult life having been...