A5045328373- Nerve injury and regeneration
- Spinal Cord Injury Research
- Urinary Bladder and Prostate Research
- Neuroscience and Neural Engineering
- Anesthesia and Pain Management
- EEG and Brain-Computer Interfaces
- Tribology and Lubrication Engineering
- Neuroscience of respiration and sleep
- Cancer Treatment and Pharmacology
- Pelvic floor disorders treatments
- CCD and CMOS Imaging Sensors
- Wound Healing and Treatments
- Anesthesia and Neurotoxicity Research
- Angiogenesis and VEGF in Cancer
- Nerve Injury and Rehabilitation
- Corneal Surgery and Treatments
- Neural dynamics and brain function
- Mesenchymal stem cell research
- Urological Disorders and Treatments
- Muscle activation and electromyography studies
- Tendon Structure and Treatment
- Pain Mechanisms and Treatments
- Mechanical and Optical Resonators
- Abdominal Surgery and Complications
- Veterinary Orthopedics and Neurology
Royal Veterinary College
2020-2024
University of London
2020-2024
University of Bristol
2014-2024
Universidad de Londres
2021
University of Bath
2021
Vascular endothelial growth factor-A (VEGF-A) is best known as a key regulator of the formation new blood vessels. Neutralization VEGF-A with anti-VEGF therapy e.g. bevacizumab, can be painful, and this hypothesized to result from loss VEGF-A-mediated neuroprotection. The multiple vegf-a gene products consist two alternatively spliced families, typified by VEGF-A165a VEGF-A165b (both contain 165 amino acids), both which are neuroprotective. Under pathological conditions, such in inflammation...
Safe hydrogel delivery requires stiffness-matching with host tissues to avoid iatrogenic damage and reduce inflammatory reactions. Hydrogel-encapsulated cell is a promising combinatorial approach spinal cord injury therapy, but lack of in vivo clinical stiffness measurements barrier their use clinics. We demonstrate that ultrasound elastography - non-invasive, clinically established tool can be used measure intraoperatively canines spontaneous injury. In line recent experimental reports, our...
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring dogs. However, the presence of chondroitin sulphate proteoglycans within extracellular matrix glial scar can inhibit efficient axonal repair limit therapeutic potential OECs. Here we have used lentiviral vectors to genetically modify canine OECs continuously deliver mammalian chondroitinase ABC at lesion...
Olfactory ensheathing cells are thought to support regeneration and remyelination of damaged axons when transplanted into spinal cord injuries. Following transplantation, improved locomotion has been detected in many laboratory models dogs with naturally-occurring injury; safety trials humans have also completed. For widespread clinical implementation, it will be necessary derive large numbers these from an accessible and, preferably, autologous, source making olfactory mucosa a good...
Spinal cord injury (SCI) can cause irreversible paralysis, with no regenerative treatment clinically available. Dogs natural SCI present an established model and facilitate translation of experimental findings in rodents to people. We conducted a prospective, single arm clinical safety study companion dogs chronic characterize the feasibility intraspinal transplantation hydrogel-encapsulated autologous mucosal olfactory ensheathing cell (mOEC) populations expressing chondroitinase ABC...
Supra-sacral spinal cord injury (SCI) causes loss of bladder fullness sensation and over-activity, leading to retention incontinence respectively. Velocity selective recording (VSR) nerve roots innervating the might enable identification activity. A 10-electrode cuff for sacral root VSR was developed tested in a sheep model during acute surgeries chronic implantation 6 months. The performed well, with 5.90±1.90 kΩ electrode, <~800 Ω tissue impedance after 189 days stable device tissues. This...
Velocity-selective recording (VSR) of electroneurogram (ENG) signals is a frequently utilized technology in the field neural with applications clinical medicine and neuroprosthetics. VSR classifies excited axon populations terms their conduction velocities using multiple recordings same ENG signal addition channels after introducing controlled time delays. This paper describes first fully integrated analogue realization complete delay-and-add process nine channels. The proposed approach uses...
Managing the urinary bladder is of primary importance to clinicians and patients after trauma spinal cord. Sacral Anterior Root Stimulators that control have been available as clinical technology for many years, however these devices cannot measure fullness or detect onset reflex voiding. In order address this fundamental limitation, it necessary develop a method recording neural signals encode fullness. This paper presents proof concept technique afferents from extradural sacral roots using...
In the development of implantable neural interfaces, recording signals from peripheral nerves is a major challenge. Since interference outside body, other biopotentials, and even random noise can be orders magnitude larger than signals, filter network to attenuate necessary. However, these networks may drastically affect system performance, especially in systems with multiple electrode cuffs (MECs), where higher number electrodes leads complicated circuits. This paper introduces formal...
New methods for the analysis of electrically-evoked compound action potentials (eCAPs) are described. Mammalian nerves tend to have broad multi-modal distributions fibre diameters, which translates into a spread conduction velocities. The method velocity selective recording (VSR) is unable distinguish between this spectral and transfer function system. concept impulse (VIF) introduced as tool differentiate these signal system attributes. new enable separate estimates broadening...
Managing the urinary bladder after spinal cord injury is of primary importance because neurogenic dysfunction leads to life-threatening complications. Sacral Anterior Root Stimulators that control have been available for many years, however, these devices cannot sense fullness or detect onset reflex voiding. In order address this fundamental limitation, paper explores possibility recording neural signals encode from sacral roots in sheep using extra-neural books. Stimulation and six (S1, S2...