A5005376090- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Algebraic Geometry and Number Theory
- Analytic Number Theory Research
- Mathematical Dynamics and Fractals
- RNA Interference and Gene Delivery
- Genomics and Rare Diseases
- Mathematics and Applications
- Renal and related cancers
- Advanced biosensing and bioanalysis techniques
- History and Theory of Mathematics
- Drug Transport and Resistance Mechanisms
- Advanced Combinatorial Mathematics
- Tissue Engineering and Regenerative Medicine
- Polynomial and algebraic computation
- MicroRNA in disease regulation
- Metabolism and Genetic Disorders
- Advanced Mathematical Identities
- Peacebuilding and International Security
- Identity, Memory, and Therapy
- Cardiac Fibrosis and Remodeling
- Pancreatic function and diabetes
- solar cell performance optimization
- Congenital heart defects research
- Skin Protection and Aging
HUN-REN Research Centre for Natural Sciences
2014-2024
Ludovika University of Public Service
2024
University of Debrecen
2013-2023
Hungarian Research Network
2020-2022
Semmelweis University
2008-2022
Institute of Molecular Life Sciences
2016-2022
Hungarian Academy of Sciences
2008-2022
Centre for Ecological Research
2022
Institute of Ecology and Botany
2022
Research Network (United States)
2022
Cardiac cell lines and primary cells are widely used in cardiovascular research. Despite increasing number of publications using these models, comparative characterization has not been performed, therefore, their limitations undetermined. We aimed to compare cardiac cardiomyocytes mature tissues a systematic manner.Cardiac (H9C2, AC16, HL-1) were differentiated with protocols. Left ventricular tissue, neonatal cardiomyocytes, human induced pluripotent stem cell-derived served as reference...
Abstract Human embryonic stem (HuES) cells represent a new potential tool for cell-therapy and gene-therapy applications. However, these approaches require the development of efficient, stable gene delivery, proper progenitor cell tissue separation methods. In HuES lines, we have generated stable, enhanced green fluorescent protein (EGFP)-expressing clones using transposon-based (Sleeping Beauty) system. This method yielded high percentage transgene integration expression. Similarly to...
Ground-mounted PV plants with multiple parallel mounting structure rows became the most common type of systems, where shading adjacent results in significant energy losses. This paper presents a detailed modelling method inter-row to calculate irradiance distribution along width rows. A modification Hay transposition model is proposed account for sky diffuse, circumsolar, and ground-reflected components. The effect uneven on power output considered by cellwise calculation aggregation I-V...
De novo mutations (DNMs) have been implicated in the etiology of schizophrenia (SZ), a chronic debilitating psychiatric disorder characterized by hallucinations, delusions, cognitive dysfunction, and decreased community functioning. Several DNMs identified examining SZ cases their unaffected parents; however, most cases, biological significance these remains elusive. To overcome this limitation, we developed an approach using induced pluripotent stem cell (iPSC) lines from each member...
ATP-binding cassette (ABC) transporters have key roles in various physiological functions as well providing chemical defense and stress tolerance human tissues. In this study, we examined the expression pattern of all ABC proteins pluripotent embryonic stem cells (hESCs) their differentiated progenies. We paid special attention to cellular localization multidrug transporter proteins.Stem cell differentiation was carried out without induction or sorting, specialized types were separated...
The imidazole alkaloid lepidiline A from the root of
Here we describe the generation of induced pluripotent stem cell lines from each member - male proband, mother, father a schizophrenia case-parent trio that participated in an exome sequencing study, and 3 de novo mutations were identified proband. Peripheral blood mononuclear cells obtained all three individuals reprogrammed using Sendai virus particles carrying Yamanaka transgenes. These iPSC (iPSC-SZ-HU-MO 1, iPSC-SZ-HU-FA iPSC-SZ-HU-PROB 1) represent resource for examining functional...
In this note a non-separable Runge-type diophantine equation related to the equal values of certain combinatorial numbers is solved.The novelty our approach avoiding use reduction methods, although as first step we have huge bound (≈ 10 50000 ) for solutions.
Some effective results for the equal values of figurate numbers are proved. Using a state-of-the-art computational method small parameter corresponding Diophantine equations resolved.
Transposable elements are widespread in all living organisms. In addition to self-reproduction, they a major source of genetic variation that drives genome evolution but our knowledge the functions human genes derived from transposases is limited. There examples transposon-derived, domesticated lost (SETMAR) or retained (THAP9) their transposase activity, however, several remnants have not been thoroughly investigated yet. These include five piggyBac-derived sequences (PGBD1-5) which share...
In this paper we provide bounds for the size of solutions Diophantine equation= y 2 , where a, b ∈ Z, a = are parameters.We also determine all integral {-4, -3, -2, -1, 4, 5, 6, 7}.
Abstract Background: De novo mutations (DNMs) have been implicated in the etiology of schizophrenia, a chronic debilitating psychiatric disorder characterized by hallucinations, delusions, cognitive dysfunction and poor community functioning. Several DNMs shown examining schizophrenia cases their unaffected parents, however most biological significance these remains elusive. To overcome this limitation we developed an approach using somatic cell reprogramming to generate induced pluripotent...
We give finiteness results for the shifted power values and polynomial of Littlewood polynomials.
A cikk a pszichológiai/lélektani műveletek (PSYOP) jelentőségét vizsgálja, különös tekintettel békefenntartó missziókban betöltött szerepükre. Az anyag igyekszik kiemelni lélektani stratégiák felhasználásának növekvő jelenlegi és jövőbeli biztonsági környezet összetettségében. PSYOP kritikus eszközként szolgálhat különböző szereplők közötti pozitív narratívák kialakításában, bizalomépítésben megbékélés elősegítésében. Ezért pszichológiai stratégiai integrációjának megvilágításával ez kiemeli...
A trauma nemcsak egyéni, hanem közösségi szinten is öröklődhet, befolyásolva a csoportok közötti ellenségképek kialakulását, fennmaradását és öröklődését. Az ilyen traumák generációkon átívelő hatása hozzájárulhat társadalmi feszültségek, gyűlölet bizalmatlanság megőrzéséhez, mely hosszú távon konfliktusokhoz, de akár háborúkhoz vezethet.
Biotechnológia, humán teljesítménytechnológia és társai. Sci-fi-nek tűnő módszerek, szakterületek, ágazatok, melyek a jövőt vetítik előre – pedig már velünk vannak. Velünk vannak az egészségügyben, mezőgazdaságban, iparban, egyre inkább megmutatják magukat katonai szektorban is. Még akkor is, ha legtöbb állam részére ezek fejlesztések egyelőre nem relevánsak, kíváncsiságot érdeklődést szabad elnyomni. A tanulás, ismeretszerzés, megtapasztalás mind fontos aspektusa annak, hogy versenyben azok...
Abstract We give effective finiteness results for the power values of polynomials with coefficients composed a fixed finite set primes; in particular, Littlewood polynomials.
Maturation of microRNAs (miRNAs) begins by the "Microprocessor" complex, containing Drosha endonuclease and its partner protein, "DiGeorge Syndrome Critical Region 8" (DGCR8). Although main function two proteins is to coordinate first step precursor miRNAs formation, several studies revealed their miRNA-independent functions in other RNA-related pathways (e.g., snoRNA decay) or, for DGCR8, role tissue development. To investigate specific roles DGCR8 various cellular pathways, we previously...
A cikk a pszichológiai/lélektani műveletek (PSYOP) jelentőségét vizsgálja, különös tekintettel békefenntartó missziókban betöltött szerepükre. Az anyag igyekszik kiemelni lélektani stratégiák felhasználásának növekvő jelenlegi és jövőbeli biztonsági környezet összetettségében való eligazodásban. PSYOP kritikus eszközként szolgálhat különböző szereplők közötti pozitív narratívák kialakításában, bizalom-építésben megbékélés elősegítésében. Ezért pszichológiai stratégiai integrációjának...