A5036731799- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Nitric Oxide and Endothelin Effects
- Lysosomal Storage Disorders Research
- Calcium signaling and nucleotide metabolism
- Lipid Membrane Structure and Behavior
- Peroxisome Proliferator-Activated Receptors
- Body Composition Measurement Techniques
- Toxin Mechanisms and Immunotoxins
- Eicosanoids and Hypertension Pharmacology
- Infrared Thermography in Medicine
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Helminth infection and control
- Cell Adhesion Molecules Research
- Blood Pressure and Hypertension Studies
- Blood properties and coagulation
- Parasites and Host Interactions
- Hydrogen's biological and therapeutic effects
- Cholesterol and Lipid Metabolism
- Cellular transport and secretion
- Calpain Protease Function and Regulation
- Parasitic Diseases Research and Treatment
- Diabetic Foot Ulcer Assessment and Management
University of Illinois Chicago
2021-2024
Universidade Federal de Minas Gerais
2017-2024
Universidade Federal de Lavras
2017
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, presents a variable clinical course, varying from asymptomatic to serious debilitating pathologies with cardiac, digestive or cardio-digestive impairment. Previous studies using two clonal T. cruzi populations, Col1.7G2 (T. I) and JG II) demonstrated that there was differential tissue distribution of these parasites during infection in BALB/c mice, predominance heart. To date little is known about mechanisms determine this...
Intracellular parasites of the genus Leishmania are causative agents leishmaniasis. The disease is transmitted by bite a sand fly vector, which inoculates parasite into skin mammalian hosts, including humans. During chronic infection lives and replicates inside phagocytic cells, notably macrophages. An interesting, but overlooked finding, that other cell types even non-phagocytic cells have been found to be infected spp. Nevertheless, mechanisms invades such had not previously studied. Here,...
Trypanosoma cruzi enters host cells by subverting the mechanism of cell membrane repair. In this process, parasite induces small injuries in leading to calcium entry and lysosomal exocytosis, which are followed compensatory endocytosis events that drive parasites into cells. We have previously shown absence both LAMP-1 2, major components membranes, decreases invasion T. cells, but they interfere with has not been described. Here we investigated role these proteins parasitophorous vacuole...
Hypertension is associated with decreased endothelial function through reduced contributions of NO. We previously discovered that flow-induced NO production in resistance arteries mice and humans critically depends on inwardly-rectifying K
Dyslipidemia-induced endothelial dysfunction is an important factor in the progression of cardiovascular disease; however, underlying mechanisms are unclear. Our recent studies demonstrated that flow-induced vasodilation (FIV) regulated by inwardly rectifying K+ channels (Kir2.1) resistance arteries. Furthermore, we showed hypercholesterolemia inhibits Kir2.1-dependent vasodilation. In this study, introduced 2 new mouse models: (1) endothelial-specific deletion Kir2.1 to demonstrate role FIV...
Introduction: The incidence of obesity has increased in children and adolescents, this become an obvious concern for public health. Objective: aim study is to compare verify the consistency three indirect methods used estimating body fat adolescents. Materials methods: Sample consisting 90 both genders —33 (males) 57 (females)—, mean age 9.45±0.72 years. To estimate fat, doubly were applied: 1) bioelectrical impedance analysis method (BIA); 2) Skinfold (SM), 3) adiposity index (BAI). Shapiro...
Shear stress is one of the major hemodynamic forces acting on endothelium. However, it not well known how endothelial cells (EC) respond mechanically to these stimuli in vivo. Here we investigated whether changes biomechanics properties and shear could increase cell susceptibility injury, contributing vascular fragility. We surgically implanted a modifier device carotid artery ApoE-knockout mice (ApoE−/−), which, due its shape, causes gradual stenosis vessel, resulting distinct patterns. Our...
ABSTRACT Intracellular parasites of the genus Leishmania are causative agents human leishmaniasis, a widespread emergent tropical disease. The parasite is transmitted by bite hematophagous sandfly vector that inoculates motile flagellated promastigote forms into dermis mammalian host. After inoculation, ultimately captured macrophages and multiply as round-shaped amastigote forms. Macrophages seem not to be first infected cells since were observed invading neutrophils whose...