A5068817441- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related gene regulation
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Cancer Mechanisms and Therapy
- Chromosomal and Genetic Variations
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Nitric Oxide and Endothelin Effects
- Genomics and Chromatin Dynamics
- Immune cells in cancer
Inserm
2020-2021
Institut Curie
2020-2021
Centre National de la Recherche Scientifique
2020-2021
Université Paris Sciences et Lettres
2020-2021
Sorbonne Université
2020
Max Planck Institute of Immunobiology and Epigenetics
2014-2016
Max Planck Society
2014
University of Freiburg
2014
The University of Texas Health Science Center at San Antonio
2007-2010
Jagiellonian University
2009
Histone acetyl transferases (HATs) play distinct roles in many cellular processes and are frequently misregulated cancers. Here, we study the regulatory potential of MYST1-(MOF)-containing MSL NSL complexes mouse embryonic stem cells (ESCs) neuronal progenitors. We find that both influence transcription by targeting promoters TSS-distal enhancers. In contrast to flies, complex is not exclusively enriched on X chromosome, yet it crucial for mammalian chromosome regulation as specifically...
Biallelic inactivation of the von Hippel-Lindau tumor suppressor gene (VHL) is linked to development hereditary and sporadic renal cell carcinoma (RCC). In absence VHL, α subunits heterodimeric hypoxia-inducible transcription factors (HIF-1α HIF-2α) are stabilized. Reactive oxygen species, generated by NAD(P)H oxidases, involved in signaling cascades malignant growth. We show that VHL-deficient cells p22phox, Nox4 protein levels NADPH-dependent superoxide generation increased. Reintroduction...
Abstract Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that impact genome regulation cell physiology throughout their RNA-centered life cycle 1 . Failure to repress ERVs is associated with cancer, infertility, senescence neurodegenerative diseases 2–4 Here, using an unbiased genome-scale CRISPR knockout screen in mouse embryonic stem cells, we identify m 6 A RNA methylation as a novel means ERV restriction. Methylation mRNAs catalyzed...