Hypertension and prehypertension pose significant public-health clinical challenges for both economically developed developing nations. Prevalence of these conditions are frequently underreported because its often-silent nature. Population-based studies that explore the occurrence correlates scarce in Saudi Arabia. This study aimed at estimating prevalence associated factors hypertension on a representative sample males females living Al-Kharj town Arabia.Cross-sectional analysis was...

Obesity and overweight are accompanied with several different chronic diseases. Overweight obesity can be measured by using body mass index (BMI) is also used widely as an of relative adiposity among any population. The aim the study to evaluate prevalence general population in Al-Kharj, Saudi Arabia. Cross-sectional analysis was undertaken from a representative sample (N = 1019) Al Kharj Anthropometric measurements including waist circumference (in centimeters), height meters), weight...

Objectives . The study aims at determining the prevalence of prediabetes and diabetes ascertaining some concomitant risk factors among males in Saudi Arabia. Methods A population-based cross-sectional including 381 adult from different institutions was recruited. Odds ratios for were calculated using log-binomial multinomial logistic regression, STATA version 12. Results participants included diabetic with a median age 45 years, average body mass index 25 ± 40 kg/m 2 , whereas waist...

There is little information on the association between watching Television (TV) and obesity in Arabian Peninsula.The aim of this study was to explore television Saudi children school-age.A case-controlled conducted with students ages 9 14 years who attended school health clinic King Abdulaziz Housing for National Guard (Iskan), Riyadh, Arabia, during period (February April 2012). During each clinic, were selected by simple random sampling (five obese five non-obese). For data collection, two...

The General Health Questionnaire-12 (GHQ-12) is one of the most unique and extensively used self-report instruments for evaluating psychological disorders strains. However, factor structure GHQ-12 has not been fully explored. current study aims to assess factorial in a large cross-sectional data-set extracted from Al Kharj central region Saudi Arabia.Population based cross sectional data was January 2016 June population recruiting 1019 respondents aged 18 above. Exploratory analysis (EFA)...

Herbal medication usage is prevalent in both developing and developed countries. The low level of awareness the possible dangers some herbs during pregnancy increases risk unwarranted sequelae. This manuscript describes first study herbal use among pregnant women Saudi Arabia. It aims to determine prevalence pregnancy, labor after delivery central region Arabia.A cross-sectional descriptive was conducted over a 5-month period from May 15 October 15, 2016. A self-administered questionnaire...

Chronic pain (CP) can be a symptom of many underlying health issues. The consequences CP may vary from slight discomfort to disruption quality life and normal functioning. In this study, we aim investigate the prevalence its associated factors in Al Kharj, Saudi Arabia. This was cross-sectional study conducted We recruited 1031 participants for our study. Data collected on socio-demographic, predictors anthropometric measurements (such as weight, height waist circumference). data analysis...

Introduction: medication without prescription is a growing public health concern or phenomenon worldwide. This cross-sectional study was designed to the trends of self-medication among Saudi population.

Abstract Background Hypercholesterolemia (HC) is an important precursor to many cardiovascular, cerebrovascular, and peripheral vascular diseases. A report conducted by the American Heart Association showed prevalence of HC be 11.9%, with around 28.5 million adults age ≥ 20 years having high cholesterol levels. This study aimed evaluate its associated risk factors among general population Al-Kharj, Saudi Arabia. Method cross-sectional was on Arabia in 2016. The representative sample...

Remarkable potential of silver nanoparticles (NPs) makes its use efficient in both biological as well industrial applications. Post harvested NPs, free from other hazards chemicals will be ideal for Thus, plant mediated method is much focused than the available approaches. The present work focusses on fabrication oxide NPs (Ag2ONPs) using methanolic bark extract Diospyros montana and characterized through sophisticated analytical techniques. UV–Vis indicated Ag2ONPs formation, FTIR analysis...

Introduction: Epilepsy is one of the most stigmatizing disorders. Stigmas and negative attitudes associating epilepsy are due to poor public awareness knowledge. This study evaluated Saudi Knowledge, awareness, attitude towards epilepsy. Materials Methods: A cross-sectional conducted during period from September 16, 2014 January 1st 2015. 20-item questionnaire adapted literature was validated distributed 422 adults living in Al-Kharj governorate, 22 participants were excluded as they have...

Abstract Background To evaluate the antibiotic resistance patterns of uropathogens isolated from adult women with acute community-acquired (CA) uncomplicated cystitis. Results Over a one-year period (May 2015–April 2016), results susceptibility testing outpatient midstream urine samples 5 different laboratories were prospectively evaluated. The study included only in all was performed using disk diffusion method VITEK-2 Compact system. and their to tested antibiotics Out 317 CA cystitis, 179...

<strong>Background/Objective:</strong> The prevalence of prediabetes and diabetes is reaching epidemic proportions across the globe. Therefore, this study aims to determine diabetes, together with its accompanying risk factors, among young females. <strong>Methods:</strong> An exploratory cross-sectional survey was conducted 638 Saudi females in Alkharj, Arabia. Statistical analysis carried out using STATA version 14. Odds ratios for associated factors were calculated log-binomial...

The ongoing global outbreak of new corona virus (SARS-CoV-2) has been recognized as public health concern since it causes high morbidity and mortality every day. Due to the rapid spreading re-emerging, we need find a potent drug against SARS-CoV-2. Synthetic drugs, such hydroxychloroquine, remdisivir have paid more attention effects these drugs are still under investigation, due their severe side effects. Therefore, aim present study was performed identify potential inhibitor main protease...

Triple-negative breast cancer (TNBC) is a significant global health issue, with high mortality rates. The chemotherapeutic drugs currently used for TNBC have side effects, impacting both normal and cells. In this study, we investigated potential use of fruit peel extract Psidium guajava (PGP) encapsulated chitosan nanoparticles (CSNPs) to combat TNBC. synthesized PGP-CSNPs were characterized using UV–vis spectroscopy, Fourier transform infra-red (FTIR) TEM GC–MS. maximum loading capacity...

Objective: To determine the incidence and causes of visual impairment blindness among patients attending eye clinics in a tertiary care setting. Method: The retrospective study was conducted Alkharj city, Saudi Arabia, from May to November 2022, comprised records who visited two main hospitals city with complaints low vision or between January 2021 December 2021. Medical history, family history ophthalmological examination results each patient were reviewed, frequency occurrence determined....

The present study aimed to investigate smart device medical apps currently preferred by physicians in Saudi Arabia and the perceived impact of on patient care.Questionnaires for this cross-sectional were randomly emailed 384 registered Commission Health Specialists database. A total 300 returned completed questionnaires, with a response rate 78.5%. Physician demographics their perceptions assessed, including questions purpose, impact, types used. Questions answered using Likert scale (1 =...

Traditional cancer treatments have posed numerous obstacles, including toxicity, multiple drug resistance, and financial cost. On the contrary, bioactive phytochemicals used in complementary alternative medicine recently increased attention due to their potential modulate a wide range of molecular mechanisms with less toxic effect. Therefore, we investigated regulatory andrographolide treat colorectal (CRC) using network pharmacology approach. Target genes were retrieved from public...

Background and Objectives: Postpartum depression (PPD) is a psychological disorder in women who recently gave birth. It can present as mild to severe depression. Multiple studies across the globe have used Edinburgh Postnatal Depression Scale reveal factors that affect prevalence of PPD. Results from various published showed high PPD Saudi Arabia. The objective this study investigate major increase other associated factors. Materials Methods: An observational cross-sectional was carried out...

(1) Background: Saudi Arabia (SA) is a country with low incidence of gastric cancer (GC). In this study, we sought to assess the epidemiology GC, its clinicopathological profiles, and association risk factors as well identify premalignant lesions (PGL) examine neoplastic progression. (2) Methods: This five-year prospective study screened for GC PGL in asymptomatic patients, aged 45-75 years (n = 35,640) living Al Kharj, Riyadh province central SA. Those who were positive high-sensitivity...

Background: Redox homeostasis is the vital regulatory system with respect to antioxidative response and detoxification. The imbalance of redox causes oxidative stress. Nuclear factor-erythroid 2 p45-related factor (Nrf2, also called Nfe2l2)/Kelchlike ECH-associated protein 1 (Keap1) signaling major regulator homeostasis. Nrf2/Keap1 reported be involved in cancer cell growth survival. A high level Nrf2 cancers associated poor prognosis, resistance therapeutics, rapid proliferation, framing as...

The objective of this study was to compare the association between mental well-being obese (classes 1 and 2), over-weight non-obese population-based individuals.A cross-sectional conducted in Al-Kharj, Saudi Arabia. A total 1019 nationals aged ≥ 18 years participated survey. BMI scores were used categorize participants into three groups: Obese, overweighted non-obese/non-overweight. Mental evaluated by using validated Arabic version General Health Questionnaire 12 (GHQ-12).We GHQ score...

Introduction Epigenetic enzymes can interact with a wide range of genes that actively participate in the progression or repression diseased condition, as they are involved maintaining cellular homeostasis. Sirtuins family Class III epigenetic modifying regulate processes by removing acetyl groups from proteins. They rely on NAD + coenzyme contrast to classical histone deacetylases (HDACs) (Class I, II, and IV) depend Zn for their activation, linking function energy levels. There seven...