A5072563508- Sirtuins and Resveratrol in Medicine
- Sinusitis and nasal conditions
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
- COVID-19 and Mental Health
- Nasal Surgery and Airway Studies
- Genomics, phytochemicals, and oxidative stress
- Psidium guajava Extracts and Applications
- Health and Well-being Studies
- Healthcare professionals’ stress and burnout
- Allergic Rhinitis and Sensitization
- Orthopedic Surgery and Rehabilitation
- Inflammatory Biomarkers in Disease Prognosis
- Free Radicals and Antioxidants
- Healthcare and Environmental Waste Management
- Head and Neck Surgical Oncology
- SARS-CoV-2 and COVID-19 Research
- Essential Oils and Antimicrobial Activity
- Peripheral Nerve Disorders
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Andrographolide Research and Applications
- Phytochemistry Medicinal Plant Applications
- Vaccine Coverage and Hesitancy
- Drug Transport and Resistance Mechanisms
Prince Sattam Bin Abdulaziz University
2022-2025
Triple-negative breast cancer (TNBC) is a significant global health issue, with high mortality rates. The chemotherapeutic drugs currently used for TNBC have side effects, impacting both normal and cells. In this study, we investigated potential use of fruit peel extract Psidium guajava (PGP) encapsulated chitosan nanoparticles (CSNPs) to combat TNBC. synthesized PGP-CSNPs were characterized using UV–vis spectroscopy, Fourier transform infra-red (FTIR) TEM GC–MS. maximum loading capacity...
Background: Redox homeostasis is the vital regulatory system with respect to antioxidative response and detoxification. The imbalance of redox causes oxidative stress. Nuclear factor-erythroid 2 p45-related factor (Nrf2, also called Nfe2l2)/Kelchlike ECH-associated protein 1 (Keap1) signaling major regulator homeostasis. Nrf2/Keap1 reported be involved in cancer cell growth survival. A high level Nrf2 cancers associated poor prognosis, resistance therapeutics, rapid proliferation, framing as...
Introduction Epigenetic enzymes can interact with a wide range of genes that actively participate in the progression or repression diseased condition, as they are involved maintaining cellular homeostasis. Sirtuins family Class III epigenetic modifying regulate processes by removing acetyl groups from proteins. They rely on NAD + coenzyme contrast to classical histone deacetylases (HDACs) (Class I, II, and IV) depend Zn for their activation, linking function energy levels. There seven...
Background: Rhinitis medicamentosa is a nonallergic inflammation of the nasal mucosa caused by topical decongestants overuse. It mainly affects young and middle-aged adults. Therefore, aim this study was to investigate attitudes pharmacists regarding utilization over-the-counter intranasal decongestants. Methods: An online cross-sectional conducted from November 2021 January 2022. The target population included who work in community pharmacies Saudi Arabia. Binary logistic regression...
The paranasal sinuses are hollowed, air-filled cavities surrounding the nasal cavity. Many pathological processes affect sinuses, but inflammatory conditions commonest, even in asymptomatic patients who undergo head imaging for other indications showing one or more abnormalities of sinuses. Our research aims to determine prevalence incidental seen among CT scanning. In addition, it provides baseline information further investigations required. study was designed evaluate all underwent...
The target specificity of drug-loaded nanoparticles can be increased by coating them with ligands that bind to the receptors overexpressed on surface cancer cells. purpose current study was examine potential therapeutic importance cetuximab-conjugated chitosan-pectin composite as novel nanocarriers for targeted delivery andrographolide colon therapy against 1,2-dimethylhydrazine (DMH) in mice. animals were divided into six groups: control, DMH, andro-treated group, unconjugated...
Coronavirus disease 2019 (COVID-19) can infect children of all ages.Despite the fact that have a lower risk exposure and are tested less frequently than adults, their incidence is similar to adults.The most effective way prevent COVID-19 infection by vaccination.The study's objective was document vaccination side effects in aged 5 18 years.This cross-sectional study had 303 participating kids between ages its sample.During months March April 2022, validated modified questionnaire circulated...
The nuclear factor-erythroid 2 p45-related factor (Nrf2, also called Nfe2l2)/Kelchlike ECH-associated protein 1 (Keap1) signaling is the major regulator of redox homeostasis. imbalance homeostasis causes oxidative stress. Keap1 one that regulates Nrf2 by binding to Nrf2. Nrf2/Keap1 reported be involved in cancer cell growth and survival. high level cancers associated with poor prognosis, resistance therapeutics rapid proliferation framing as an interesting target biology. Sirtuins (SIRT1-7)...
Objective: To estimate the Primary Hypothyroidism and to study its effects on Quality of Life those patients. Study design: It was a Cross-Sectional done using random sampling. Sample size: 463 patients Duration location study: between December 2018 2019 in outpatient clinics tertiary care hospital Riyadh. tool: The quality life these assessed by World Health Organization (WHO) Survey 36-Item Short Form (SF-36) questionnaire with score less than 50% considered be ‘Poor quality’. Results:...
The number of COVID-19 cases has continued to rise since the World Health Organization (WHO) declared Coronavirus Disease 2019 (COVID-19) as a global pandemic in March 2020.At this time, WHO received reports about 460 million confirmed illnesses and over 6 deaths.In Saudi Arabia, nearly surpassed 750 thousand, with responsible for approximately 9,000 deaths.Vaccination is most effective approach prevent pandemic, persons who have had three doses are better protected than those not.The goal...
Due to various factors, medical students are at higher risk of perceived stress than the general population during pandemic .This study was planned assess levels and occurrence mental health issues among graduate in Kingdom Saudi Arabia.Following scales were used for this -1) DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure-Adult (CCSM-A) -for assessing prevalence common issues, 2) Perceived Stress Scale 3) Student due COVID-19.Questionnaire global score related COVID-19.123...
Background: Rhinitis medicamentosa (RM) is a nonallergic inflammation of the nasal mucosa caused by topical decongestants overuse. It mainly affects young and middle-aged adults. The most effective management counseling patients about importance discontinuing these agents. Therefore, pharmacists play vital part in discussing safety medications, thus, assessing their attitudes toward (NDs) an important step reducing incidence RM.Methods: An electronic survey was distributed to practicing...
Sirtuins are a family of Class III epigenetic modifying enzymes involved in regulating cellular processes through the removal acetyl groups from proteins. They rely on NAD+ as coenzyme contrast with classical HDACs (Class I, II, and IV) that depends Zn+ for their activation, linking function to energy levels. There seven mammalian sirtuin isoforms (SIRT1-7), each located different subcellular compartments. act master regulators homeostasis, responding changes nutrient availability status....
Medical students are more likely than the general population to experience perceived stress during pandemic due many variables.This study aimed evaluate levels and prevalence of different mental health conditions among graduate medical in Al Kharj City.An anonymous online survey was conducted Prince Sattam bin Abdulaziz University (PSAU).For this investigation, following scales were used measure common issues: DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure-Adult (CCSM-A); Perceived...