A5044157158- Animal Nutrition and Physiology
- Hypothalamic control of reproductive hormones
- Animal Behavior and Reproduction
- Growth Hormone and Insulin-like Growth Factors
- Reproductive Physiology in Livestock
- Spectroscopy Techniques in Biomedical and Chemical Research
- Neuropeptides and Animal Physiology
- Avian ecology and behavior
- Developmental Biology and Gene Regulation
- Glioma Diagnosis and Treatment
- Plant Reproductive Biology
- Bird parasitology and diseases
- Pharmacological Effects and Assays
- Zebrafish Biomedical Research Applications
- Thyroid Disorders and Treatments
- Regulation of Appetite and Obesity
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Congenital heart defects research
- MicroRNA in disease regulation
- Meat and Animal Product Quality
- Spectroscopy and Chemometric Analyses
- Physiological and biochemical adaptations
- Epigenetics and DNA Methylation
- Olfactory and Sensory Function Studies
University of Manchester
2013-2025
University of Oxford
2017
University of Central Lancashire
2006-2016
Healing Foundation
2016
University of Strathclyde
2015
LGBT Foundation
2011-2014
Preston's College
2014
National and Kapodistrian University of Athens
2005-2007
University of Toronto
2004
Roslin Institute
1993-1995
The time spent each day on the nest and rate of formation brood patch before onset incubation were measured in bantams ( Gallus domesticus ) related to changes concentrations plasma LH prolactin. hens progressively more 5 days so that by first they spending than 90% their this way. concentration prolactin increased while fell successive incubation: increase preceded fall 2 days. closely followed In four out five nesting behaviour was an secretion An injection chicken antiserum into...
The ability to diagnose cancer rapidly with high sensitivity and specificity is essential exploit advances in new treatments lead significant reductions mortality morbidity. Current diagnostic tests observing tissue architecture specific protein expression for cancers suffer from inter-observer variability, poor detection rates occur when the patient symptomatic. A method of using 1 μl human serum, attenuated total reflection—Fourier transform infrared spectroscopy pattern recognition...
Abstract Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year UK. A rapid, reagent‐free and cost‐effective diagnostic regime using serum spectroscopy would allow for rapid results swift treatment planning monitoring within clinical environment. We report use of ATR‐FTIR spectral data combined a RBF‐SVM diagnosis gliomas (high‐grade low‐grade) from non‐cancer sensitivities specificities on average 93.75 96.53% respectively. The proposed has...
The interactions between broody behaviour and changes in concentrations of plasma prolactin LH were investigated bantam hens. Adoption newly hatched chicks caused incubating hens to leave their nests prevented decreasing as rapidly deprived not given chicks. Further, the allowed rear came back into lay later (P less than 0.001) Plasma decreased increased nests: these reversed when re-nested. nest-deprived re-nesting birds always synchronous; this was particularly clear immediately after nest...
The larval epidermis of Xenopus is a bilayered epithelium, which an excellent model system for the study development and function mucosal mucociliary epithelia. Goblet cells develop in outer layer while multiciliated ionocytes sequentially intercalate from inner to layer. Here, we identify characterise fourth cell type, small secretory (SSC). We show that these controlled by transcription factor Foxa1 they into relatively late, at same time as embryonic hatching. Ultrastructural molecular...
Mucosal surfaces such as fish gills interface between the organism and external environment are major sites of foreign Ag encounter. In gills, balance inflammatory responses to waterborne pathogens regulatory toward commensal microbes is critical for effective barrier function overall health. mammals, IL-4 IL-13 in concert with IL-10 essential balancing immune suppressing inflammation. Although considerable progress has been made field immunology recent years, whether counterparts these key...
Abstract Background Lavender odour is commonly used to alleviate mild anxiety. Double blind studies are difficult conduct with odours, and there few reliable investigations of lavender's efficacy. Method Orally administered lavender capsules (placebo, 100, 200 µl) were tested in a randomised between‐subjects ( n = 97) double‐blind study. Film clips elicit Measures included anxiety, State Trait Anxiety Inventory (STAI), mood, positive negative affect scale (PANAS), heart rate (HR), galvanic...
Abstract Fibroblast growth factor (FGF) signalling plays a major role during early vertebrate development. It is involved in the specification of mesoderm, control morphogenetic movements, patterning anterior‐posterior axis, and neural induction. In mammals, 22 FGF ligands have been identified, which can be grouped into seven subfamilies according to their sequence homology function. We cloned 17 fgf genes from Xenopus tropicalis analysed temporal expression by RT‐PCR spatial whole mount...
FoxG1 is a conserved transcriptional repressor that plays key role in the specification, proliferation and differentiation of telencephalon, expressed from earliest stages telencephalic development through to adult. How interaction with co-factors might influence multiplicity diversity function not known. Here, we show TLE2, Xenopus tropicalis co-repressor Groucho/TLE family, crucial for regulating early activity FoxG1. We TLE2 co-expressed ventral telencephalon neural plate stage...
Raman spectroscopy is a non-destructive, non-invasive, rapid and economical technique which has the potential to be an excellent method for diagnosis of cancer understanding disease progression through retrospective studies archived tissue samples. Historically, biobanks are generally comprised formalin fixed paraffin preserved as result these specimens often used in spectroscopic research. Tissue this state dewaxed prior analysis reduce contributions spectra. However, although procedures...
Brain regionalisation, neuronal subtype diversification and circuit connectivity are crucial events in the establishment of higher cognitive functions. Here we report requirement for transcriptional repressor Fezf2 proper differentiation neural progenitor cells during development Xenopus forebrain. Depletion induces apoptosis postmitotic progenitors, with concomitant reduction forebrain size differentiation. Mechanistically, found that stimulates by promoting Wnt/β-catenin signalling...
Article12 May 2020Open Access Dynamic properties of noise and Her6 levels are optimized by miR-9, allowing the decoding oscillator Ximena Soto Corresponding Author [email protected] orcid.org/0000-0003-2680-1837 Faculty Biology Medicine Health, School Medical Sciences, The University Manchester, UK Search for more papers this author Veronica Biga Jochen Kursawe Mathematics Statistics, St Andrews, Robert Lea Parnian Doostdar Riba Thomas Nancy Papalopulu orcid.org/0000-0001-6992-6870...
ABSTRACT Plasma prolactin began to increase significantly about 5 days after the onset of incubation in both sexes dove reach a peak at time hatch. At this time, concentration plasma female was higher than male. In middle period levels measured over 24-h remained constant sexes, although male sits during day and for rest time. Nest deprivation resulted sharp, significant decline sexes. Newly hatched squabs stimulated release only those doves which had been incubating eggs several days. A...