A5083528590- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Migraine and Headache Studies
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- Advanced Sensor and Energy Harvesting Materials
- Nicotinic Acetylcholine Receptors Study
- Plant Stress Responses and Tolerance
- RNA and protein synthesis mechanisms
- Pluripotent Stem Cells Research
- Protein Degradation and Inhibitors
- Plant Parasitism and Resistance
- Renal and related cancers
- Renal cell carcinoma treatment
- Heavy metals in environment
- CRISPR and Genetic Engineering
- Black Holes and Theoretical Physics
- Conducting polymers and applications
- Electrical Contact Performance and Analysis
- Psychosomatic Disorders and Their Treatments
- Plant Gene Expression Analysis
- Aluminum toxicity and tolerance in plants and animals
- Chromatin Remodeling and Cancer
Changchun University of Technology
2023-2025
Zhejiang Center for Disease Control and Prevention
2025
Yanbian University
2025
Southwest University of Science and Technology
2023-2024
Massachusetts General Hospital
2020-2024
Harvard University
2020-2024
Center for Excellence in Molecular Cell Science
2015-2021
University of Chinese Academy of Sciences
2015-2021
Chinese Academy of Sciences
2015-2020
Center for Cancer Research
2020
RNA polymerase I (Pol I) transcription takes place at the border of fibrillar center (FC) and dense component (DFC) in nucleolus. Here, we report that individual spherical FC/DFC units are coated by DEAD-box helicase DDX21 human cells. The long noncoding (lncRNA) SLERT binds to RecA domains promote adopt a closed conformation substoichiometric ratio through molecular chaperone-like mechanism resulting formation hypomultimerized loose clusters coat DFCs, which is required for proper liquidity...
Abstract Oncogenic fusion proteins generated by chromosomal translocations play major roles in cancer. Among them, fusions between EWSR1 and transcription factors generate oncogenes with powerful chromatin regulatory activities, capable of establishing complex gene expression programs permissive precursor cells. Here we define the epigenetic 3D connectivity landscape Clear Cell Sarcoma, an aggressive cancer driven EWSR1-ATF1 gene. We find that displays a distinct DNA binding pattern requires...
Cell fate transitions observed in embryonic development involve changes three-dimensional genomic organization that provide proper lineage specification. Whether similar events occur within tumor cells and contribute to cancer evolution remains largely unexplored. We modeled this process the pediatric Ewing sarcoma investigated high-resolution looping large-scale nuclear conformation associated with oncogenic fusion protein EWS-FLI1. show chromatin interactions are dominated by highly...
Synovial sarcoma (SyS) is an aggressive mesenchymal malignancy invariably associated with the chromosomal translocation t(X:18; p11:q11), which results in in-frame fusion of BAF complex gene SS18 to one three SSX genes. Fusion generates aberrant transcriptional regulator, which, permissive cells, drives tumor development by initiating major chromatin remodeling events that disrupt balance between BAF-mediated activation and polycomb-dependent repression. Here, we developed SyS organoids...
Abstract Intrinsically disordered regions (IDRs) in DNA-associated proteins are known to influence gene regulation, but their distribution and cooperative functions genome-wide regulatory programs remain poorly understood. Here we describe DisP-seq (disordered protein precipitation followed by DNA sequencing), an antibody-independent chemical assay that can simultaneously map endogenous through a combination of biotinylated isoxazole next-generation sequencing. profiles composed thousands...
The power supply problem of perception terminals such as micrometeorological monitoring sensors on high‐voltage transmission lines restricts their large‐scale development. Herein, a hybrid self‐powered remote system that integrates triboelectric and electromagnetic technologies is proposed. In the system, wind energy harvesting device plays an important role. It includes three functions: generator can stabilize 5 F supercapacitor at 5.34 V within 417 s to microcontroller unit, sensor units,...
EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT1-dependent gene regulation networks target genes. We show that is a powerful activator controlling oncogenic expression program characterizes primary tumors. Similar wild type WT1, has two isoforms differ in their DNA binding domain find they have distinct are...
Abstract Background Epidemiological studies have confirmed the relationship between personality trait neuroticism and physical health. However, frailty remains unconfirmed. This study employed a bi-directional two-sample Mendelian randomization (MR) approach to investigate causal frailty. Methods The genome-wide association (GWAS) data from UK Biobank contained twelve neuroticism-related traits with 489,212 participants. genetic index were extracted Swedish TwinGene, involving 175,226...
To validate the Chinese version of Identification Migraine screener (ID-Migraine), assess migraine prevalence, identify potential associated factors, and impact on quality life in a community Harbin, PR China.A community-based, cross-sectional study was conducted Songbei district Harbin. After excluding people who did not usually reside community, 2,588 adults were invited to participate study. Eligible participants underwent physical examination before completing questionnaire addressing...
To determine the prevalence and awareness of migraine among university students in Harbin, China.A cross-sectional study was conducted Harbin Medical University from April 1 to June 30, 2012. The Chinese version Identification Migraine Screener (ID-Migraine) used as screening tool, evaluated by a structured questionnaire. A subgroup randomly selected fill out questionnaire again evaluate its test-retest reliability. internal consistency reliability validity were tested using Cronbach's alpha...
To investigate the association between glucose and insulin metabolism migraine, as well diabetes mellitus (DM) at a Chinese community level.A community-based, case-control study was performed in Heihe City, China. A survey conducted door to by eight trained investigators. Migraine diagnosed using International Classification of Headache Disorders (ICHD-III) beta criteria. total 2,023 participants completed questionnaire, underwent physical examination, donated fasting blood. After excluding...
Methylation status plays a causal role in carcinogenesis targeted tissues. However, the relationship between DNA methylation of multiple genes blood leukocytes and colorectal cancer (CRC) susceptibility as well interactions dietary factors CRC risks are unclear. We performed case-control study with 466 patients 507 cancer-free controls to investigate association among individual genes, CpG site (MCSM), heterogeneous susceptibility. Peripheral levels were detected by performing...
We study a novel class of higher derivative theories for interacting massless gravitons in Minkowski spacetime. These were first discussed by Wald decades ago, and are characterized scattering amplitudes essentially different from general relativity many its modifications. discuss various aspects these theories, including the Lagrangian construction, violation asymptotic causality, amplitudes, non-renormalization, possible implications emergent condensed matter systems.
Ensuring the reliability and stability of long‐distance power transmission requires monitoring lines' grid environment's health. For this purpose, study proposes a triboelectric nanogenerator (TENG) with anti‐self‐excited vibration. In case aeolian vibration in line, oscillation (AO‐TENG) generates electricity via cohesive work between spring additional weight block that drives TENG. As result, prevents excessive surge voltage from damaging back‐end circuit, capacitor contributes...