A5017944600- Liver Disease Diagnosis and Treatment
- Animal Disease Management and Epidemiology
- Hepatitis C virus research
- Viral Infections and Immunology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- MRI in cancer diagnosis
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Glycation End Products research
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Diabetes Treatment and Management
- Metabolism and Genetic Disorders
- Microbial infections and disease research
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diet, Metabolism, and Disease
- Respiratory viral infections research
- Lipid metabolism and disorders
- Diet and metabolism studies
- Systemic Lupus Erythematosus Research
Mansoura University
2018-2023
Veterinary Serum and Vaccine Research Institute
2018-2021
Agricultural Research Center
2021
Hospital for Tropical Diseases
2015-2019
The pathogenesis of nonalcoholic fatty liver disease (NAFLD) may include increased insulin resistance, upregulation proinflammatory cytokines, lipopolysaccharide, and BMI. Rifaximin is a minimally absorbable antibiotic that might act against broad spectrum gut bacteria. This study aimed to investigate the effects rifaximin on NAFLD.Fifty participants with biopsy-proven steatohepatitis (NASH) were registered in this multicentric, double-blind, randomized, placebo-controlled study. BMI,...
Abstract Background and Aim The relationship between Helicobacter pylori ( H. ) nonalcoholic fatty liver disease NAFLD is a matter of debate. We achieved this prospective work to study whether infection risk factor for . Methods A cohort multicenter pilot 369 adults without at baseline was followed up 2 years. Serum leptin, insulin, tumor necrosis factor‐α, adiponectin, interleukin‐6 were measured using an enzyme‐linked immunosorbent assay ELISA ). Homeostasis model assessment insulin...
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of progressive and chronic injury. Mean platelet volume (MPV) the neutrophil-lymphocyte ratio (N/L ratio) may be considered cheap simple markers inflammation in many disorders. We aimed to investigate clinical utility MPV N/L predict fibrosis NAFLD patients presence nonalcoholic steatohepatitis (NASH).A total 873 with biopsy-proven 150 healthy controls were included. Patients divided into two groups: non-NASH group (n=753) NASH...
Aim This study aimed to assess the interobserver agreement of magnetic resonance (MR) imaging Liver Imaging Reporting and Data System version 2018 (LI-RADS v2018). Subjects Methods Retrospective analysis was done for 119 consecutive patients (77 male 42 female) at risk hepatocellular carcinoma who underwent dynamic contrast MR imaging. Image by 2 independent blinded readers arterial phase hyperenhancement, washout appearance, enhancing capsule size. Hepatic lesions were classified into 7...
Non-alcoholic fatty liver disease (NAFLD) is a major element of the metabolic syndrome, with prevalence about 20–30% all diseases [1,2]. This figure depends on certain factors, includ...
Objectives This work aimed to measure serum vascular endothelial growth factor (VEGF) levels before and after Conventional transarterial chemoembolization (cTACE) versus drug-eluting beads (DEB)-TACE evaluate its efficacy in predicting response therapy tumor recurrence.Methods 114 patients with unresectable hepatocellular carcinoma complicating hepatitis C virus-related cirrhosis were included. They underwent cTACE (58) or DEB-TACE (56). VEGF measured on days 1 30 TACE. Patients complete...
Background and objective Spontaneous bacterial peritonitis (SBP) is a common infection with life-threatening sequelae in cirrhotic ascites. The purpose of this retrospective cohort study was to recognize the predictors SBP build up noninvasive system exclude or establish an episode SBP. Patients methods Of 1194 consecutive patients ascites, only 966 were enrolled study. diagnosed once polymorphonuclear count at least 250 cells/mm 3 and/or there positive ascitic fluid culture result....
The relationship between hepatitis B virus (HBV) infection, leptin and insulin resistance remains unclear. We hypothesised links serum in non-diabetic patients with chronic viral infection their relation to liver fibrosis.We recruited 190 untreated HBV 72 healthy controls. Serum leptin, fasting glucose, insulin, function tests (LFTs), C-peptide Homeostasis model assessment-IR (HOMA-IR) were measured/calculated by ELISA standard techniques.Serum (both P < 0.001), HOMA-IR (P = 0.021) several...
Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) PVT is a matter debate. This study aimed to investigate the NAFLD. Methods: We included 94 out 105 consecutive NAFLD patients in this prospective cohort addition from healthy control group. evaluated biochemical, clinical, immunological, histopathological parameters; waist circumference (WC); leptin; adiponectin;...
Backgroundand study aim: Hepatocellular Carcinoma ( HCC) is regarded as one of the most widespread leading causes mortality annually .The frequent risk factors for HCC are chronic viral hepatitis infection, which account 80% all cases globally.This aims to highlight epidemiological, clinical, laboratory and radiological characteristics in patients attending Tropical Medicine Department. Patients Methods:A Retrospective was conducted on medical records Department determine socio demographic,...
To assess role of the apparent diffusion coefficient (ADC) in Liver Imaging Reporting and Data System (LI-RADS) version 2018 for prediction hepatocellular carcinoma (HCC).Retrospective analysis 137 hepatic focal lesions 108 patients at risk HCC, who underwent magnetic resonance imaging liver. Hepatic were classified according to LI-RADS-v2018, ADC was calculated by 2 independent blinded reviewers.The mean LR-1 LR-2 2.11 ± 0.47 2.08 × 10-3 mm2/s, LR-3 1.28 0.12 1.36 0.16 LR-4, LR-5 LR-TIV...
The advanced glycation end products (AGEs) have been implicated in different diseases' pathogenesis, but their role hepatocellular carcinoma (HCC) is still a matter of debate. This study aims to investigate the association AGEs with HCC development patients hepatitis C-related cirrhosis.Only 153 181 non-diabetic cirrhosis were consecutively involved this pilot cohort prospective study, along 34 healthy control participants. Demographic characteristics, biochemical parameters, clinical data,...
The present study aimed to prepare a combined inactivated pneumo-4 vaccine containing bovine viral diarrhoea, infectious rhinotracheitis (IBR), parainfluenza-3(PI-3) and respiratory syncytial virus (BRSV) adjuvanted with carbomer compare the animal protection scope its product mate Pneumo-4 alhydragel .Carbomer adjuvant stimulated higher levels longer lasting antibody than vaccines of equivalent antigenic content aluminium hydroxide gel adjuvant.Quality control results proved that either by...
The ideal adjuvant is one that able to aid in early stimulation of the humeral immune response, and promote production high antibody titers would persist for long duration as well stimulate cellular response.This immunological study was conducted reveal aluminum hydroxide gel effect with use oil adjuvants on response polyvalent foot mouth disease (FMD) vaccine sheep.Twenty five sheep, were divided group (five animals/group) where 1 st vaccinated FMD ISA 206 vaccine, 2 nd + 3 rd 201 4 th 5...
Foot-and-mouth disease (FMD) is an acute infectious that infects cloven-hoofed mammals, such as pigs, cattle, cattle and goats Dara, et al., (2013).The causative agent a single stranded positive-sense RNA virus belongs to the genus Aphthovirus in family Picornaviridae.The has seven serological types, identified as; O, A, C, SAT1, SAT2, SAT3 Asia1 (2013).FMD characterized by fever, lameness vesicular lesions on feet, tongue, snout, teats, with high morbidity low mortality Rodriguez Grubman...
This work was designed to provide high protective, long-lasting immunity against FMD by enhancing the immunogenicity of trivalent vaccine using carbomer as adjuvant G. pigs an alternative cheapest animal model for quality control testing prepared vaccines formulae.Guinea were chosen experimental models develop concepts and techniques study PD50 because similarities clinical symptoms in these animals those swine cattle saving cost, three different formulae inactivated including serotypes O...
There are millions of chronic hepatitis C (CHC) virus-infected patients who have been treated with a combination therapy (interferon and ribavirin) achieved virological response (SVR) worldwide. The aim this study is to evaluate the risk factors for de-novo diabetes mellitus in CHC an SVR.A total 214 nondiabetic SVR baseline homeostasis model assessment (HOMA) less than or equal 2 were divided into group A, which included 108 BMI 25, B, 106 at least 25 30. HOMA insulin resistance (IR)...
Foot-and-mouth disease (FMD) is an acute infectious that infects cloven-hoofed mammals, such as pigs, cattle, cattle and goats Dara, et al., (2013).The causative agent a single stranded positive-sense RNA virus belongs to the genus Aphthovirus in family Picornaviridae.The has seven serological types, identified as; O, A, C, SAT1, SAT2, SAT3 Asia1 (2013).FMD characterized by fever, lameness vesicular lesions on feet, tongue, snout, teats, with high morbidity low mortality Rodriguez Grubman...
The control of foot-and-mouth disease (FMD) in animals was considered to be important effectively contain the endemic areas, so that vaccination is effective limiting spread disease. progress FMD vaccine production directed primarily towards safety vaccine, purity antigen and selection proper additives as adjuvants preservatives.Thimerosal (Merthiolate) has been used a preservative since 1930. Nevertheless, Thiomersal itself proved very toxic because it containsmercury. Hence, current...
Abstract Background: The advanced glycation end products (AGEs) have been implicated in different diseases' pathogenesis, but their role hepatocellular carcinoma (HCC) is still a matter of debate. This study aims to investigate the association AGEs with HCC development patients cirrhosis. Methods: Only 153 181 non-diabetic cirrhosis were consecutively involved this pilot cohort prospective study, along 34 healthy control participants. Demographic characteristics, biochemical parameters,...