A5088627530- Supramolecular Self-Assembly in Materials
- Polydiacetylene-based materials and applications
- Collagen: Extraction and Characterization
- Luminescence and Fluorescent Materials
- Lipid Membrane Structure and Behavior
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- RNA Interference and Gene Delivery
- Photochromic and Fluorescence Chemistry
- Material Properties and Processing
- Marine Biology and Environmental Chemistry
- Rock Mechanics and Modeling
- Advanced biosensing and bioanalysis techniques
- Geotechnical and Geomechanical Engineering
- Advanced Sensor and Energy Harvesting Materials
- Silk-based biomaterials and applications
- Electrohydrodynamics and Fluid Dynamics
- Supramolecular Chemistry and Complexes
- Seismology and Earthquake Studies
- Tissue Engineering and Regenerative Medicine
- Crystallography and molecular interactions
Central Leather Research Institute
2012-2024
Council of Scientific and Industrial Research
2015-2024
Ben-Gurion University of the Negev
2020-2024
Academy of Scientific and Innovative Research
2014-2020
In recent years, several fluorenylmethoxycarbonyl (Fmoc)-functionalized amino acids and peptides have been used to construct hydrogels, which find a wide range of applications. Although hydrogels prepared from mono Fmoc-functionalized acids, herein, we demonstrate the importance an additional Fmoc-moiety in hydrogelation double L-lysine [Fmoc(Nα)-L-lysine(NεFmoc)-OH, (Fmoc-K(Fmoc))] as low molecular weight gelator (LMWG). Unlike other acid gelators, Fmoc-K(Fmoc) exhibits pH-controlled...
Abstract Melanin pigments have various properties that are of technological interest including photo‐ and radiation protection, rich coloration, electronic functions. Nevertheless, laboratory‐based synthesis melanin melanin‐like materials with morphologies chemical structures specifically optimized for these applications, is currently not possible. Here, produced by enzymatic oxidation a supramolecular tripeptide in tyrosine 1D morphology demonstrated, retained during the process while...
Abstract Supramolecular hydrogels typically undergo a gel‐to‐sol transition with heat, as intermolecular interactions within the gel weaken. Although gel‐to‐gel transitions during heating are rare, they may occur due to minor rearrangements caused by thermal forces in supramolecular self‐assembled structure. Here, an unprecedented temperature‐induced assisted chiral inversion hydrogel system is presented. The results from left‐handed M‐type helix right‐handed P‐type helix, attributed...
Abstract The quest to understand and mimic proton translocation mechanisms in natural channels has driven the development of peptide‐based artificial facilitating efficient transport across nanometric membranes. It is demonstrated here that hierarchical peptide self‐assembly can form micrometers‐long nanochannels. fourfold symmetrical design leverages intermolecular aromatic interactions align self‐assembled cyclic nanotubes, creating hydrophilic nanochannels between them. Titratable amino...
Charge-transfer (CT) gel materials obtained from low-molecular-weight (LMW) compounds through a supramolecular self-assembly approach have received fascinating attention by many researchers because of their interesting material property and potential applications. However, most the CT constructed were organogels while construction gels in form hydrogel is challenge solubility issue water, which considerably limits use hydrogels. Herein, for first time, we report new LMW gelator...
Supramolecular gels are three-dimensional network structures formed by the hierarchical self-assembly of small molecules through weak noncovalent interactions. On basis various interactions contributed specific functional groups/moieties, with different architectures can be constructed that smart to external stimuli such as pH, type solvent, stress, temperature, etc. In present work, we explore oscillatory shear response supramolecular self-assembled systems low-molecular-weight (LMW)...
Although a few Fmoc-functionalised amino acids (Fmoc-AA) are capable of forming hydrogels, the exact levels hydrophobicity, hydrogen bonding, and ionic nature Fmoc-AA gelator required for hydrogel formation remains uncertain. Here, role hydrophobicity acid side chain, particularly in hydrogel, was studied by using Fmoc-norleucine (Fmoc-Nle) its simple sulfur analogues such as Fmoc-methionine (Fmoc-M) which γCH2 Fmoc-Nle is replaced sulfur. Results indicate that Fmoc-M forms thermally...
Although the role of intermolecular aromatic π-π interactions in self-assembly di-l-phenylalanine (l-Phe-l-Phe, FF), a peptide that is known for hierarchical structure, well established, influence intramolecular on morphology self-assembled structure FF has not been studied. Herein, investigated and analogous alanine (Ala)-containing dipeptides, namely, l-Phe-l-Ala (FA) l-Ala-l-Phe (AF). The results reveal these dipeptides only form self-assemblies, but also exhibit remarkable differences...
Background: This paper presents the effect of solution properties and operating parameters polyethylene oxide (PEO) based nanofiber using a wire electrode-based needleless electrospinning. Methods: The feed was prepared PEO dissolved in water or water-ethanol mixture. is blended with Bovine Serum Albumin protein (BSA) as model drug to study electrospinning process on stability loaded protein. polymer such viscosity, surface tension, conductivity were controlled by adjusting solvent salt...
Self-assembly is one of the important and fruitful methods to develop various biomaterials, especially hydrogels, from biologically small molecules. Two such molecules are d-biotin (B-vitamin), which plays several vital roles in biology used biomedical field, biocytin, as an intracellular marker also identify neurons. Despite significance these biomolecules, their usage form hydrogel very limited. Herein, for first time, a pH-stimuli responsive supramolecular based on amidation product...
Peptide based self-assembled structures, especially those from smaller peptides, have attracted much research interest due to their potential applications as biomaterials. These structures been produced using different solvents (one of the methods), including alcohols, except fluorinated which are believed support non-aggregated structures. Herein, we studied ability 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) induce self-assembly an aromatic dipeptide, namely...
The formation of spontaneous 3D self-assembled hierarchical structures from 1D nanofibers is a significant breakthrough in materials science. Overcoming the major challenges associated with developing these structures, such as uncontrolled self-assembly, complex procedures, and machinery, has been formidable task. However, current discovery reveals that simple π-system (fluorenyl)-functionalized natural aromatic amino acids, phenylalanine (Fmoc-F) tyrosine (Fmoc-Y), can form bio-inspired...
While biomacromolecules such as proteins are shown to form fibrous spherulites, which generally “semicrystalline” in nature, here we show that a simple, low molecular weight compound fluorenylmethoxycarbonyl-functionalized phenolic amino acid (Fmoc-L-tyrosine) can “fibrous” spherulites with highly “cross-linked” microfibrils using the supramolecular self-assembly process.