Polycystic ovary syndrome (PCOS) is the most common reproductive dysfunction in premenopausal women. PCOS associated with oxidative stress (OS), which main risk factor for renal diseases. This study aimed to investigate mechanisms responsible injury a hyperandrogenemic female rat model.This was conducted from December 2019 September 2021 at Shiraz Nephro-Urology Research Centre, University of Medical Sciences (Shiraz, Iran). Thirty Sprague-Dawley rats were randomly divided into three groups...

One of the most prevalent healthcare-associated infections in pediatric intensive care unit is ventilator-associated pneumonia (VAP). VAP not only results prolonged hospital and (ICU) stays but also imposes higher costs on patients healthcare system. Therefore, it essential to implement preventive measures. The lung-protective properties taurine are recognized, this research focuses assessing impact supplementation preventing VAP. This double-blind, randomized clinical trial was conducted at...

Abstract Background Diabetic nephropathy and hepatopathy are health problems described by specific renal hepatic structure function disturbances. The protective effects of the stem cell secretome have been shown in several kidney liver diseases. current study aims to evaluate capability conditioned media derived from human Wharton’s jelly mesenchymal cells (hWJ-MSCs-CM) alleviate diabetic complications. Methods Twenty Sprague Dawley rats were made through injection STZ (60 mg/kg, i.p.). At...

Biomaterials, either metallic, ceramic, or polymeric, can be used in medicine as a part of the implants, dialysis membranes, bone scaffolds, components artificial organs. Polymeric biomaterials cover vast range biomedical applications. The biocompatibility and immunocompatibility polymeric materials are fundamental importance for their possible therapeutic uses, immune system intervene materials' performance. Therefore, based on application, different routes utilized immunoregulation.As...

Introduction: Remote ischemic conditioning upregulates endogenous protective pathways in response to ischemia-reperfusion injury. This study tested the hypothesis that limb remote per-conditioning (RIPerC) exerts cardioprotective effects via renin-angiotensin system (RAS)/inducible nitric oxide synthase (iNOS)/apelin pathway. Methods: Renal injury (I/R) was induced by bilateral occlusion of renal pellicles for 60 minutes, followed 24 hours reperfusion; sham-operated rats served as controls....

Gentamicin (GM) is an antibiotic belonging to aminoglycoside family that might induce nephrotoxicity in human and animal models via oxidative stress. Toll-like receptors (TLRs) are part of innate immune systems participate inflammatory responses. In this regard, we investigated the effect GM on kidney functional structural parameters, enzymatic antioxidant levels, mRNA expression TLR4 IL6 rat kidney. Adult male Sprague Dawley rats were randomly divided into two groups (n = 10): Control (100...

Diabetic nephropathy occurs in about one-third of diabetic patients. This health problem is characterized by increased urinary albumin excretion, leading to decreased glomerular filtration rate and renal failure. In this regard, previous investigations have revealed the possibility a relationship between vitamin D deficiency nephropathy. The present study assessed albuminuria patients with type 2 diabetes.This was conducted 200 participants diabetes mellitus from December 2019 January 2021....

Ovarian granulosa cells (GCs) are essential for follicular development. advanced glycation end-products (AGEs) accumulation is related to GCs dysfunction. Alpha-lipoic acid (ALA) illustrates therapeutic capabilities infertility-related disorders. Therefore, this study assessed the effects of ALA on AGEs-induced hormonal

A rare case of a 35 years old woman presented with renal arcuate vein thrombosis (RAVT) and acute kidney injury (AKI) following upper respiratory tract symptoms toxic substance ingestion. Histopathological evaluation the patient's tissue indicated venous in veins. Anticoagulation Apixaban, direct oral anticoagulant (DOAC), was commenced, resolved during hospital stay. Hitherto, limited number studies have shown concurrent presentation RAVT overt AKI patients ingestion nephrotoxic agents....

The underlying pathophysiology of pulmonary arterial hypertension (PAH) is multifactorial; however, the significance chronic volume overload and its subsequent effects on cardiac function must be studied thoroughly. main objective this study was to determine predictive parameters PAH in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) using transthoracic echocardiography (TTE) bioimpedance analysis (BIA).In cross-sectional study, 43 eligible CAPD were chosen. examined by...

Abstract Introduction To achieve optimal blood pressure control in continuous ambulatory peritoneal dialysis (CAPD) patients, identifying methods of volume assessment with the strongest correlation is essential. Methods In this cross‐sectional study, 52 CAPD patients were assigned to automated office (AOBP) measurement, pedal pitting edema, bioimpedance analysis (BIA), and inferior vena cava collapsibility index (IVCCI%) measurement. Data analyzed using STATA ver.17, significance level was p...

Abstract Background and Aims Pruritus in patients undergoing hemodialysis is a highly prevalent complication that affects quality of life. Several medications are currently used for the treatment uremic pruritus, but these not satisfactory. There few studies about beneficial effect oral Tacrolimus on dermatologic problems such as pruritus. Considering condition ESKD probable presence their future plan, this trial designed to assess antipruritic compared with placebo. Method This multicenter,...