A5038480990- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Advanced biosensing and bioanalysis techniques
- Fatty Acid Research and Health
- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
- Monoclonal and Polyclonal Antibodies Research
- Advanced Biosensing Techniques and Applications
- Salivary Gland Disorders and Functions
- Cardiac Ischemia and Reperfusion
- Cholesterol and Lipid Metabolism
- Molecular Biology Techniques and Applications
- Cell Image Analysis Techniques
- Metabolomics and Mass Spectrometry Studies
- Carcinogens and Genotoxicity Assessment
- Protein Kinase Regulation and GTPase Signaling
- Neuropeptides and Animal Physiology
- Pregnancy and preeclampsia studies
- Molecular Junctions and Nanostructures
- Tryptophan and brain disorders
- RNA Interference and Gene Delivery
- Folate and B Vitamins Research
- Single-cell and spatial transcriptomics
- Antioxidant Activity and Oxidative Stress
CSIRO Health and Biosecurity
2014-2024
The University of Adelaide
2000-2024
Health Sciences and Nutrition
2000-2018
Commonwealth Scientific and Industrial Research Organisation
2007-2017
Animal, Food and Health Sciences
2013-2014
Technologies pour la Santé
2011
Weatherford College
2007
1 The acute effects of n-3 polyunsaturated fatty acids were determined on whole-cell sodium currents recorded in isolated adult rat ventricular myocytes using patch clamp techniques. 2 docosahexaenoic acid (22:6, n-3), eicosapentaenoic (20:5, n-3) and α-linolenic (18:3, dose-dependently blocked the evoked by a voltage step to −30 mV from holding potential −90 with EC50 values 6.0 ± 1.2, 16.2 1.3 26.6 μM, respectively. 3 Docosahexaenoic acid, at 25 μM shifted dependence activation current...
The metabolomic and proteomic basis of mild cognitive impairment (MCI) Alzheimer’s disease (AD) is poorly understood, the relationships between systemic abnormalities in metabolism AD/MCI pathogenesis unclear. This study compared signature plasma from cognitively normal (CN) dementia patients diagnosed with MCI or AD, to identify specific cellular pathways new biomarkers altered progression disease. We analysed 80 samples individuals as well age- gender-matched CN individuals, by utilising...
Abstract Previous studies have shown that mild cognitive impairment (MCI) may be reflective of the early stages more pronounced neurodegenerative disorders such as Alzheimer's disease (AD). There is a need for minimally invasive and inexpensive diagnostic to identify those who exhibit cellular pathology indicative MCI AD risk so they can prioritized primary preventative measures. The hypothesis was approach using cytological markers in isolated buccal mucosa cells used individuals both AD....
The metabolomic and proteomic basis of mild cognitive impairment (MCI) Alzheimer's disease (AD) is poorly understood the relationships between systemic abnormalities in metabolism AD/AMCI pathogenesis are unclear.
Alzheimer's disease (AD) is a degenerative brain disorder and the most common form of dementia. Minimally invasive approaches are required that combine biomarkers to identify individuals who at risk developing mild cognitive impairment (MCI) AD, appropriately target clinical trials for therapeutic discovery as well lifestyle strategies aimed prevention. Buccal mucosa cells from Australian Imaging, Biomarkers Lifestyle Flagship Study Ageing cohort (n=60) were investigated cytological markers...
Alzheimer’s disease (AD) is an insidious disease. Its distinctive pathology forms over a considerable length of time without symptoms. There need to detect this disease, before even subtle changes occur in cognition. Hallmark AD biomarkers, tau and amyloid-β, have shown promising results CSF blood. However, detecting early these biomarkers others will involve screening wide group healthy, asymptomatic individuals. Saliva feasible alternative. Sample collection economical, non-invasive saliva...
Abstract This paper describes a novel strategy to create microarray of G‐protein coupled receptors (GPCRs), an important group membrane proteins both physiologically and pharmacologically. The H 1 ‐histamine receptor the M 2 ‐muscarinic were used as model GPCRs in this study. embedded liposomes created from cellular extracts Spodoptera frugiperda ( Sf9 ) insect cell culture line with its accompanying baculovirus protein insert for overexpression receptors. Once captured onto surface these...
Here we describe the adaptation of laser scanning cytometry (LSC) to measure micronuclei (MN) automatically in lymphocytes. MN frequencies were determined irradiated human lymphocytes using cytokinesis-block technique, and results from LSC compared with visual scoring obtained slides cells stained Fast Green 4',6-diamidino-2-phenylindole (DAPI). This fluorescent approach allowed clear identification binucleated detection MN. The dose responses measured visually by showed similar trends...