A5004580643- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Cancer-related cognitive impairment studies
- Pharmacological Effects and Toxicity Studies
- Advanced Neuroimaging Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Immune Cell Function and Interaction
- Neurobiology of Language and Bilingualism
- Transcranial Magnetic Stimulation Studies
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
- Brain Metastases and Treatment
S. M. Kirov Military Medical Academy
2020-2024
is to assess the effectiveness and safety of stereotactic photodynamic therapy (sPDT) with 5-aminolevulinic acid (5-ALA) in patients recurrent malignant supratentorial gliomas functionally relevant brain areas.
Introduction . Mutations in the isocytrate dehydrogenase 1 and 2 genes (IDH1 IDH2) are considered driver genetic events gliomas. Their frequency reaches 7080 % low-grade gliomas secondary glioblastomas, their oncogenic effect is realized by accumulation of metabolite 2-hydroxyglutarate, which disrupts DNA protein methylation processes. The aim study was to analyze associations between presence IDH1/2 mutations clinical morphological parameters glial tumors. Material Methods included 147...
Background. Epileptic seizures represent one of the leading clinical manifestations glial brain tumors that develop on average in 51% cases. In gliomas, epileptogenesis is quite complex and multifactorial. Objective: to study a role expressed glutamine synthetase enzyme, as well cystine/glutamate transporter (xCT system, SLC7A11) pathogenesis epilepsy developing patients with cerebral gliomas. Material methods. The included 32 supratentorial age disease onset (diagnosis) was 50.69±18.01...
The incidence of primary brain tumors is increasing worldwide. When assessing the treatment delivered to patients with gliomas, their quality life (QOL) an essential criterion for consideration. It necessary search and specify factors, which determine QOL changes in tumors. indicators gliomas were assessed terms following factors: clinical (presence epileptic seizures, seizures type frequency, antiepileptic drug treatment, presence speech disorders pareses), demographic (sex), age diagnosis,...
Objectives Stereotactic photodynamic therapy (sPDT) using 5-aminolaevulinic acid (5-ALA) as a cytotoxic photosensitizer may be potentially prospective treatment option for malignant gliomas. Material and Methods We analyzed data from 10 patients with recurrent gliomas of the brain who were treated sPDT at Department Neurosurgery Military-Medical Academy S. M. Kirov, 2020 to November 2021. Three again after 3, 7, 15 months due relapse. Results The median age was 55.5 years, range 30–60 there...
Introduction. With standard treatment of glioblastoma, the vast majority cases result in relapse disease, for which there is no consensus on effectiveness repeat resection. The lack Level 1 evidence efficacy surgical removal recurrent glioblastomas (GB) indicates that problem has not been resolved and stimulates interest finding ways to combat this disease. Purpose. To study effect a tumor overall life expectancy post-relapse survival time patients with glioblastomas. Materials methods....
Introduction. Supplementary motor area (SMA) syndrome is a symptom complex resulting from damage to the premotor cortex and it’s subcortical projection. There no generally accepted protocol for functional mapping of SMA during neurosurgical intervention in this area. The objective publication present review literature clinical cases practice that describes treatment two patients with glioblastomas posterior regions superior frontal gyrus IOM. Given localization tumor dominant hemisphere, one...
The immune status of 58 patients with gliomaswas evaluated. Prior to surgical treatment in low-grade gliomas was observed higher (p ˂0.05) the absolute number total T-lymphocytes, Thelper cells and NK-cells compared high grade glioma. Postoperatively group II explicit reduction CD3 + , CD4 – CD56 increase population CD8 cytotoxic T-lymphocytes. Reducing lymphocytes diffuse astrocytomas anaplastic after treatment, maybe, related migration these into area intervention. At same time III, IV...