A5101422299- Plant Pathogens and Fungal Diseases
- Genomics and Phylogenetic Studies
- Cancer, Hypoxia, and Metabolism
- Protist diversity and phylogeny
- Bioinformatics and Genomic Networks
- Cancer, Lipids, and Metabolism
- Caveolin-1 and cellular processes
- Forest ecology and management
- Plant Parasitism and Resistance
- Botany and Plant Ecology Studies
- Horticultural and Viticultural Research
- Bryophyte Studies and Records
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Drug Transport and Resistance Mechanisms
- Plant Pathogens and Resistance
- Genetic diversity and population structure
- Ferroptosis and cancer prognosis
- Signaling Pathways in Disease
- Machine Learning in Bioinformatics
- Axon Guidance and Neuronal Signaling
- Tree-ring climate responses
- Congenital heart defects research
- PI3K/AKT/mTOR signaling in cancer
- Plant Pathogenic Bacteria Studies
Wenzhou Medical University
2025
The University of Tokyo
2020-2023
Chinese University of Hong Kong
2023
Tzu Chi University
2023
State Key Laboratory of Medical Neurobiology
2022
Hokkaido Research Organization
2022
Huashan Hospital
2022
Fudan University
2022
Wuhan Polytechnic University
2021
Institute of Biomedical Sciences, Academia Sinica
2018
Abstract Background Genome-wide association studies (GWAS) have revealed numerous loci associated with stroke. However, the underlying mechanisms at these in pathogenesis of stroke and effective drug targets are elusive. Therefore, we aimed to identify causal genes its subtypes. Methods Utilizing multidimensional high-throughput data generated, integrated proteome-wide study (PWAS), transcriptome-wide (TWAS), Mendelian randomization (MR), Bayesian colocalization analysis prioritize that...
Order Spizellomycetales was delineated based on a unique suite of zoospore ultrastructural characters and currently includes five genera 14 validly published species, all which have propensity for soil habitats. We generated DNA sequences from small (SSU), large (LSU) 5.8S ribosomal subunit genes to assess the monophyly species in this order. The 53 cultures analyzed included isolates described were based, plus other spizellomycetalean cultures. Phylogenetic placement these chytrids explored...
Acute hepatic injury caused by inflammatory liver disease is associated with high mortality. This study examined the role of caveolin-1 (Cav-1) in lipopolysaccharide (LPS) and D-galactosamine (GalN)-induced fulminant wild type Cav-1-null (Cav-1-/- ) mice. Hepatic Cav-1 expression was induced post-LPS/GalN treatment wild-type LPS/GalN-treated Cav-1-/- mice showed reduced lethality markedly attenuated damage, neutrophil infiltration hepatocyte apoptosis as compared to deletion significantly...
Caveolin-1 (Cav-1) interacts with and mediates protein trafficking various cellular functions. Derlin-1 is a candidate for the retrotranslocation channel of endoplasmic reticulum proteins. However, little known about how glycosylated degradation. Here, we identified Cav-1 as key player in Derlin-1- p97-mediated cyclooxygenase 2 (COX-2) ubiquitination augmented interaction COX-2 mediated degradation C terminus-dependent manner. Suppression decreased COX-2, mutation Asn-594 to Ala disrupt...
Upregulation of L-type amino acid transporter 1 (LAT1) has been reported to be associated with a poor prognosis in variety malignant tumors. However, the impact LAT1 hepatocellular carcinoma (HCC) remains unclear. The objective this study was investigate whether expression HCC established clinicopathological features. Quantitative reverse transcription polymerase chain reaction used detect mRNA 23 pairs fresh-frozen tissues and corresponding noncancerous tissues. Results showed that level...
Adenoviral vector is an efficient tool for gene transfer. Protein expression regulated by a number of factors, but the regulation copy remains to be investigated further.Assessed flow cytometry, we demonstrated significant linear correlation between average fluorescence intensity green fluorescent protein (GFP) and wide range multiplicity infection (MOI), spanning from 0.01 200. Average GFP was calculated mean (MFI) × percentage (POI) (MFI POI) observed in cells transduced with...
Research Highlights: The complete chloroplast genome for eight individuals of Japanese larch, including from the isolated population at northern limit range (Manokami larch), revealed that larch forms a monophyletic group, within which Manokami can be phylogenetically placed in larch. We detected intraspecific variation possible candidate cpDNA markers Background and Objectives: natural distribution is limited to mountainous central part Honshu Island, Japan, with an larch). In this study,...
Background The tubby ( tub) and tubby-like protein (tulp) genes encode a small family of proteins found in many organisms. Previous studies have shown that TUB TULP mammalian involve obesity, neural development, retinal degeneration. purpose this study was to investigate the role Drosophila king (ktub) rhodopsin 1 (Rh1) endocytosis degeneration upon light stimulation. Results ktub mutants were generated using imprecise excision. Wild type mutant flies raised dark or constant conditions....
Toll-like receptor 4 has an important role in inflammation and immunity. Whether TLR4 signaling contributes to the link between insulin resistance islet β cell dysfunction is unanswered question. Here, we show that face of same high-fat continuous stimulation for 24 weeks, TLR4-/- HF mice, weight, fraction liver, epididymal fat pad fraction, as well blood glucose levels were lower than WT group. In O2 consumption, CO2 production activities higher Glucose tolerance test, test release suggest...
Rhizophydium macroporosum Karling is reported as a new record to Taiwan. It isolated from mud of pond, and has been pure cultured on 1/4YpSs medium. A mature zoosporangium possesses one six exit papillae. Zoospores emerge en masse the discharged pores are surrounded by gelatinous material. The ultrastructure zoospore this fungus first here.
<h3>Background</h3> Although immune checkpoint blockade (ICB) has shown promise in cancers, only a modest proportion of hepatocellular carcinoma (HCC), patients showed desirable and durable responses. The success combining ICB anti-vascular endothelial growth factor as the first-line treatment for advanced-stage HCC highlights great potential cell (EC) normalization enhancing immunotherapy response. Epigenetic regulation by bromodomain-containing protein 4 (BRD4) plays critical roles...
Establishing apicobasal polarity, involving intricate interactions among polarity regulators, is key for epithelial cell function. Though phosphatase of regenerating liver (PRL) proteins are implicated in diverse biological processes, including cancer, their developmental role remains unclear. In this study, we explore the Drosophila PRL (dPRL) photoreceptor development. We reveal that dPRL, requiring a C-terminal prenylation motif, highly enriched apical membrane developing cells. Moreover,...
Habitat loss of forest tree species distributed in cold temperate and alpine zones is a serious issue the context global warming. Considering that intraspecific variation essential for adaptation to changing environments, seed weight, leaf traits, sapling size sub-alpine broad-leaved species, Betula ermanii, was examined this study using seeds collected from 11 populations across its natural distribution. Seeds were sown beds, containerized seedlings grown greenhouse with uniform environment...
Alzheimer's disease (AD) is a neurodegenerative condition characterized pathologically by neuritic plaques and neurofibrillary tangles. The objective in the present transcriptional profiling study was to identify both neurosusceptibility intrinsic neuroprotective factors at molecular level, not confounded downstream consequences of pathology. We thus studied post-mortem cortical tissue 28 cases who were non-APOE4 carriers (called APOE3 group) 13 APOE4 carriers. Because APOE genotype major...
The incidence of metabolic syndrome (MetS) is increasing, and n-3 polyunsaturated fatty acids (PUFAs) in salmon (Oncorhynchus) phospholipids can effectively reduce the risk MetS.Under intervention 4% phospholipid, levels fasting blood glucose (FBG), insulin, monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α) were significantly reduced plasma MetS mice, whereas adiponectin was increased. By screening, we found that 18 differential metabolites,...