Timothée David

ORCID: 0000-0003-0581-2406
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About
Contact & Profiles
Research Areas
  • Monoclonal and Polyclonal Antibodies Research
  • Bone and Dental Protein Studies
  • Glycosylation and Glycoproteins Research
  • Immunotherapy and Immune Responses
  • Cell Adhesion Molecules Research
  • Legal Systems and Institutions
  • Oral microbiology and periodontitis research
  • Cancer Immunotherapy and Biomarkers
  • Protease and Inhibitor Mechanisms
  • Bone health and treatments
  • Cancer Research and Treatments
  • Migration, Identity, and Health
  • Oral and Maxillofacial Pathology
  • European and International Law Studies
  • Health, Medicine and Society
  • Immune Response and Inflammation

Inserm
2020-2025

Université de Montpellier
2020-2025

Institut de Recherche en Cancérologie de Montpellier
2021-2025

Institute of Justice
2020

Introduction Triple-negative breast cancer (TNBC) prognosis is poor. Immunotherapies to enhance the antibody-induced natural killer (NK) cell antitumor activity are emerging for TNBC that frequently immunogenic. The aspartic protease cathepsin D (cath-D), a tumor cell-associated extracellular protein with protumor and poor marker in TNBC, prime target antibody-based therapy induce NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC). This study investigated whether Fc-engineered...

10.1136/jitc-2023-007135 article EN cc-by-nc Journal for ImmunoTherapy of Cancer 2024-01-01

ABSTRACT Extracellular matrix (ECM) remodeling by proteases results in the release of protein fragments that promote tumor progression and metastasis. The protease cathepsin D (cath-D), a marker poor prognosis triple-negative breast cancer (TNBC), is aberrantly secreted microenvironment. Using degradomic analyses TAILS, we discovered matricellular SPARC substrate extracellular cath-D. In vitro , cath-D induced limited proteolysis C-terminal Ca 2+ binding domain at acidic pH, leading to...

10.1101/2020.10.22.350082 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2020-10-22
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