A5054781173- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Analytical Chemistry and Chromatography
- Mitochondrial Function and Pathology
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- Enzyme Structure and Function
- Transgenic Plants and Applications
- Food Allergy and Anaphylaxis Research
- Cholesterol and Lipid Metabolism
- Nuclear Physics and Applications
- Virus-based gene therapy research
- Dermatology and Skin Diseases
- Steroid Chemistry and Biochemistry
- RNA Interference and Gene Delivery
- Alzheimer's disease research and treatments
University of British Columbia
2023-2024
Institute of Natural Science
2015
Kyung Hee University
2015
Konkuk University
2010-2014
Phospholipids (PLs) are the major building block molecules of cellular membranes. Their composition varies depending on cell types and compartments. Thus, information regarding PL distribution in tissue has important physiological pathological significance. Recent developments imaging mass spectrometry (IMS) have allowed complete mapping species tissue. The IMS technique can detect different classes PLs as well their location directly from sections. head groups carry either positive and/or...
Alzheimer's disease (AD) is the most common form of dementia; however, at present time there no disease-modifying drug for AD. There increasing evidence supporting role lipid changes in process normal cognitive aging and etiology age-related neurodegenerative diseases. AD characterized by presence intraneuronal protein clusters extracellular aggregates β-amyloid (Aβ). Disrupted Aβ kinetics may activate intracellular signaling pathways, including tau hyperphosphorylation proinflammatory...
Since the development of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, this procedure has been specifically used for analyzing proteins or high molecular weight compounds because interference matrix signals in regions low range. Recently, scientists have using a wide range chemical as matrices that ionize small molecules spectrometer and overcome limitations MALDI spectrometry. In study, we developed new combination 3-hydroxycoumarin (3-HC) 6-aza-2-thiothymine (ATT),...
Neuronal membrane phospholipids are highly affected by oxidative stress caused ischemic injury. Thus, it is necessary to identify key lipid components that show changes during ischemia develop an effective approach prevent brain damage from The recent development of MALDI imaging MS (MALDI IMS) makes possible change between damaged and normal regions directly tissues. In this study, we conducted IMS on rat brains injury detected various showed unique distributions areas the brain. Among...
Despite exciting advances in gene editing, the efficient delivery of genetic tools to extrahepatic tissues remains challenging. This holds particularly true for skin, which poses a highly restrictive barrier. In this study, we ran head-to-head comparison between Cas9 mRNA or ribonucleoprotein (RNP)-loaded lipid nanoparticles (LNPs) deliver editing into epidermal layers human aiming
Since the emergence of proteomics methods, many proteins specific for renal cell carcinoma (RCC) have been identified.Despite their usefulness diagnosis RCC, such do not provide spatial information on diseased tissue.Therefore, identification cancerspecific that include location is needed.Recently, matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) based imaging (IMS) has emerged as a new tool analysis distribution well either or small molecules in tissues.In this...
Direct tissue imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization and time-of-flight (MALDI-TOF) has become increasingly important in biology medicine, because this technology can detect the relative abundance spatial distribution of interesting proteins tissues. Five thyroid cancer samples, along with normal tissue, were sliced transferred onto conductive glass slides. After scanning MALDI-TOF equipped a smart beam laser, images created for individual masses...
Matrix assisted laser desorption ionization (MALDI) mass spectrometry is commonly used to analyze biological molecules such as proteins, peptides and lipids from cells or tissue. Recently MALDI Imaging (IMS) has been widely applied for the identification of different drugs their metabolites in This special feature made MALDI-MS a common choice investigation molecular histology pathological samples well an important alternative other conventional imaging methods. The basic advantages...