A5114948988- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Emotions and Moral Behavior
- Hernia repair and management
- Gastrointestinal disorders and treatments
- Social Robot Interaction and HRI
- Pediatric Hepatobiliary Diseases and Treatments
- Noise Effects and Management
- Emotion and Mood Recognition
- Urological Disorders and Treatments
- RNA and protein synthesis mechanisms
- Congenital gastrointestinal and neural anomalies
- Testicular diseases and treatments
- CRISPR and Genetic Engineering
- Thyroid Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Cultural Differences and Values
- Tracheal and airway disorders
- Gaze Tracking and Assistive Technology
- Tactile and Sensory Interactions
- Teratomas and Epidermoid Cysts
RIKEN Center for Brain Science
2018-2022
Waseda University
2002-2022
National Center For Child Health and Development
2013-2017
Saitama Children's Medical Center
2010-2013
Kinjo University
2012
Kyoto Institute of Technology
2012
Gunma University
2011
Tokyo University of Pharmacy and Life Sciences
2011
Cardiovascular Institute of the South
2010
Tokyo City University
2010
Several theories of emotion propose that emotional responses are largely determined by the way events appraised. To determine whether proposed dimensions appraisal consistent across cultures, 973 Ss from United States, Japan, Hong Kong, and People's Republic China were asked to describe experiences. Few differences between 3 cultures observed on more primitive (pleasantness, attentional activity, certainty, coping ability, goal/need conduciveness) 2 cognitively complex (legitimacy norm/self...
Abstract Base Editor (BE) and Target-AID (activation-induced cytidine deaminase) are engineered genome-editing proteins composed of Cas9 deaminases. These base-editing tools convert C:G base pairs to T:A at target sites. Here, we inject either BE or mRNA together with identical single-guide RNAs (sgRNAs) into mouse zygotes, compare the efficiencies two distinct in vivo. consistently show higher efficiency (10.0–62.8%) compared that (3.4–29.8%). However, unexpected substitutions...
Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD), only one protective mutation has identified so far in humans. Here we identify possible deletion the 3'-UTR amyloid precursor protein (App) gene mice. We use an App knock-in mouse model carrying humanized Aβ sequence and three AD endogenous gene. Genome editing zygotes using multiple combinations CRISPR/Cas9 tools produces genetically mosaic animals with various deletions. Depending on efficiency,...
Rationale: The vasoactive peptide angiotensin II (Ang II) is a potent cardiotoxic hormone whose actions have been well studied, yet questions remain pertaining to the downstream factors that mediate its effects in cardiomyocytes. Objective: vivo role of myocyte enhancer factor (MEF)2A target gene Xirp2 Ang II–mediated cardiac remodeling was investigated. Methods and Results: Here we demonstrate MEF2A (also known as cardiomyopathy associated 3 [ CMYA3 ]) an important effector signaling...
Summary Alzheimer’s disease (AD) is a major cause of dementia, with the number patients this condition anticipated to exceed 50 million worldwide in near future. Despite extensive research efforts, no effective measures are available facilitate prevention or treatment AD, which due part lack animal models able closely replicate human-like state. Here, we describe generation three mutant marmoset individuals exon 9 PSEN1 gene product has been deleted ( -ΔE9). Such ΔE9 mutations have reported...
We previously developed single App knock-in mouse models of Alzheimer's disease (AD) harboring the Swedish and Beyreuther/Iberian mutations with or without Arctic mutation (AppNL-G-F AppNL-F mice, respectively). These showed Aβ pathology, neuroinflammation, cognitive impairment in an age-dependent manner. The former model exhibits extensive pathology as early 6 months, but is unsuitable for investigating metabolism clearance because renders resistant to proteolytic degradation prone...
We previously developed single App knock-in mouse models of Alzheimer's disease (AD) that harbor the Swedish and Beyreuther/Iberian mutations with or without Arctic mutation (AppNL-G-F AppNL-F mice). have now generated mice devoid (AppG-F mice) evaluated its characteristics. Amyloid β peptide (Aβ) pathology was exhibited by AppG-F from 6 to 8 months age accompanied neuroinflammation. Aβ-secretase inhibitor, verubecestat, attenuated Aβ production in mice, but not AppNL-G-F indicating are more...
In words such as happy, sad, angry, and afraid, the English language provides a taxonomy of emotional states. But to what extent is this or culture bound? This article describes method that compares emotion in different natural languages. Translations for 14 were obtained Chinese Japanese. Native speakers rated which each named was expressed by standard set facial expressions. The correlation between resulting profiles any two index their similarity. proved sensitive revealing both overall...
Popularity of minimally invasive surgeries has led to the development stapled intestinal anastomosis for adults. The advanced instruments used in this technique are getting suitable with small lumens neonates and infants. We reviewed compared intraoperative postoperative results hand-sewn anastomoses children.The operative data children who underwent between March 2005 December 2011 were collected analyzed retrospectively. Furthermore, we patients colostomy closure anorectal malformation (4...
Minimally invasive surgery is recognized as a safe and feasible technique for resecting congenital lung lesions. In our hospital, video-assisted thoracoscopic (VATS) was initially performed through 5-6-cm incision with several trocars under differential ventilation (assisted-VATS). Complete (complete-VATS) artificial pneumothorax introduced in 2009 allowed smaller infants. The aim of this study to compare the outcomes complete-VATS assisted-VATS lesions.Between January 2004 October 2012, 22...
Exostosis is one of the most common benign bone lesions. It could be a solitary lesion or multiple lesions presented as part HME. This condition often affects metaphyseal region long bones, including femur, tibia, humerus and ribs. Rib exostosis may cause severe complications such pneumothorax, hemothorax, diaphragmatic injury. We report two patients with asymptomatic rib who underwent surgical excision to prevent complications. The first patient was 13-year-old male At eight-year follow-up,...
The authors have been developing anthropomorphic head-eye robots, in order to elucidate the human vision system from an engineering point of view, and develop a new head mechanism function for humanoid robot having ability communicate naturally with human. We developed "WE-3R III" (Waseda Eye No.3 Refined III) auditory sensation, cutaneous sensation facial expression eyes, eyelids, eyebrows, lips, jaw neck. It is said that sensations include contact, pressure, cold, warmth pain, so tactile...
Indirect inguinal hernia is one of the most common congenital abnormality in children. In approximately 15–20% female patients, sac contains an ipsilateral ovary, but a few cases have been reported which uterus and both ovaries are within sac. Ultrasonography very effective tool to detect prolapsed organs hernia; however, detection may be difficult infants. The present study describes rare case containing ovaries. was sliding Bevan's technique adopted for radical herniorrhaphy. clinical...
In this study the authors have been developing anthropomorphic head-eye robots, in order to elucidate human vision system from an engineering point of view, and develop a new human-friendly communication system. We developed robot "WE-3R" (Waseda Eye No.3 Refined) as subsystem humanoid "Hadaly-2". WE-3R has eyelids hardware, while functions retina (adaptation) iris (adjustment pupil diameter) are realized software so can adjust brightness. The pursue objects 3 dimensional space with...
Abstract Milk curd syndrome was first reported in the 1960s, but gradually forgotten because of its low incidence thereafter. This condition pre‐term infants has been over last decade and again attracted neonatologists' attention. The present report describes a infant with milk syndrome. Abdominal distension evident 14 days after start feeding fortified expressed milk. X‐ray showed multiple intraluminal masses surrounded by halo air, ultrasound indicated hyperechoic masses. Along that...
Using pulsed field gel electrophoresis (PFGE) and Southern hybridization techniques, a physical map of Moraxella catarrhalis strain ATCC25238 was constructed to provide basic genetic knowledge this bacterium that has attracted attention in recent years as human pathogen. Restriction endonuclease NotI cut the genome into 10 fragments SmaI 9, molecular size estimated be 1,940 kilobases. Location 12 genes participating biosynthesis purine, pyrimidine nine kinds amino acids were determined on...