Karla Therese L. Sy

ORCID: 0000-0003-0608-9811
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • COVID-19 epidemiological studies
  • Traumatic Brain Injury Research
  • Cardiac Arrest and Resuscitation
  • Health disparities and outcomes
  • Tuberculosis Research and Epidemiology
  • COVID-19 Impact on Reproduction
  • Global Maternal and Child Health
  • HIV/AIDS Research and Interventions
  • COVID-19 and healthcare impacts
  • HIV/AIDS Impact and Responses
  • Data-Driven Disease Surveillance
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • SARS-CoV-2 detection and testing
  • HIV, Drug Use, Sexual Risk
  • Renal Diseases and Glomerulopathies
  • Suicide and Self-Harm Studies
  • Chronic Kidney Disease and Diabetes
  • Urban Transport and Accessibility
  • Adolescent Sexual and Reproductive Health
  • Long-Term Effects of COVID-19
  • Public Health Policies and Education
  • Air Quality and Health Impacts
  • Posttraumatic Stress Disorder Research
  • COVID-19 Digital Contact Tracing

Boston University
2019-2024

Pfizer (United States)
2023-2024

Icahn School of Medicine at Mount Sinai
2016-2018

Health Resources and Services Administration
2017

Mount Sinai Hospital
2017

New York Stem Cell Foundation
2015

The basic reproductive number (R0) is a function of contact rates among individuals, transmission probability, and duration infectiousness. We sought to determine the association between population density R0 SARS-CoV-2 across U.S. counties. conducted cross-sectional analysis using linear mixed models with random intercept fixed slopes assess R0, controlled for state-level effects intercepts. also assessed whether was differential county-level main mode transportation percentage as proxy...

10.1371/journal.pone.0249271 article EN cc-by PLoS ONE 2021-04-21

We paired high-resolution travel-time metrics with a SARS-CoV-2 testing location database in the United States. Median travel time to sites is longer counties lower population density, and higher percent of minority uninsured individuals. Differential geographic accessibility can recapitulate healthcare disparities bias transmission estimates.

10.1093/jtm/taaa076 article EN cc-by-nc Journal of Travel Medicine 2020-05-13

Background There is a growing literature on the association of SARS-CoV-2 and other chronic conditions, such as noncommunicable diseases. However, little known about impact coinfection with tuberculosis. We aimed to compare risk death recovery, well time-to-death time-to-recovery, in COVID-19 patients without

10.1080/23744235.2020.1806353 article EN Infectious Diseases 2020-08-18

Using data from New York City January 2020 to April 2020, we found an estimated 28-day lag between the onset of reduced subway use and end exponential growth period severe acute respiratory syndrome coronavirus 2 within boroughs. We also conducted a cross-sectional analysis associations human mobility (i.e., ridership) on week 11, sociodemographic factors, disease 2019 (COVID-19) incidence as 26, 2020. Areas with lower median income, greater percentage individuals who identify non-White...

10.1093/aje/kwaa277 article EN cc-by-nc American Journal of Epidemiology 2020-12-24

Background: The United States CDC has reported that racial and ethnic disparities in the COVID-19 pandemic may part be due to socioeconomic disadvantages require individuals continue work outside their home a lack of paid sick leave. However, data-driven analyses determinants burden are still needed. Using data from New York City (NYC), we aimed determine how factors impact human mobility burden. Methods/Summary: large amount heterogeneity status (SES) demographics among neighborhoods. We...

10.1101/2020.05.28.20115949 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2020-05-30

Abstract The basic reproductive number (R 0 ) is a function of contact rates among individuals, transmission probability, and duration infectiousness. We sought to determine the association between population density R SARS-CoV-2 across U.S. counties, whether could be used as proxy for rates. conducted cross-sectional analysis using linear mixed models with random intercept fixed slopes assess . also assessed this was differential county-level main mode transportation-to-work percentage....

10.1101/2020.06.12.20130021 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2020-06-13

Since 2000, there has been a substantial global reduction in the vertical transmission of HIV. Despite effective interventions, gaps still remain progress towards elimination many low-income and middle-income countries. We developed mathematical model to determine most cost-effective combinations interventions prevent transmission.

10.1016/s2214-109x(23)00588-0 article EN cc-by The Lancet Global Health 2024-02-15

Traumatic brain injury (TBI) often results in cognitive impairment, and trajectories of functioning can vary tremendously over time across survivors. Traditional approaches to measuring performance require face-to-face administration a battery objective neuropsychological tests, which be time- labor-intensive. There are numerous clinical research contexts in-person testing is undesirable or unfeasible, including monitoring older adults individuals with disability for whom travel challenging,...

10.1089/neu.2017.5347 article EN Journal of Neurotrauma 2018-03-29

The Philippines confirmed local transmission of COVID-19 on 7 March 2020. We described the characteristics and epidemiological time-to-event distributions for laboratory-confirmed cases in recorded up to 29 April 2020 followed until 22 May median age 8212 was 46 years (IQR 32-61), with 46.2% being female 68.8% living National Capital Region. Health care workers represented 24.7% all detected infections. Mean length hospitalisation those who were discharged or died 16.00 days (95% CI...

10.1017/s0950268820002137 article EN cc-by-nc-nd Epidemiology and Infection 2020-01-01

To examine the relationship between traumatic brain injury (TBI) and criminal behavior in youth who are incarcerated or on probation Texas.Seven juvenile justice facilities.Juvenile offenders state county correctional facilities probation.Screening for TBI was conducted among adolescents at 7 centers.Participants were administered Brain Injury Screening Questionnaire, results linked to participants' offense history psychiatric diagnoses.One 4 met criteria TBI, majority of injuries occurred...

10.1097/htr.0000000000000274 article EN Journal of Head Trauma Rehabilitation 2017-01-06

Differentiated service delivery (DSD) models aim to improve the access of human immunodeficiency virus treatment on clients and reduce requirements for facility visits by extending dispensing intervals. With advent COVID-19 pandemic, minimising client contact with healthcare facilities other clients, while maintaining continuity avoiding loss care, has become more urgent, resulting in efforts increase DSD uptake. We assessed extent which coverage antiretroviral (ART) intervals have changed...

10.1002/jia2.25808 article EN cc-by Journal of the International AIDS Society 2021-10-01

Abstract Tuberculosis (TB) is a risk factor for chronic obstructive pulmonary disease (COPD), but COPD also predictor of TB. The excess life-years lost to caused by TB can potentially be saved screening and treating infection. We examined the number that could preventing TB-attributable COPD. compared observed (no intervention) counterfactual microsimulation models constructed from rates in Danish National Patient Registry (covering all hospitals between 1995 2014). In population COPD-naive...

10.1093/aje/kwad042 article EN American Journal of Epidemiology 2023-02-22

Abstract Importance Access to testing is key a successful response the COVID-19 pandemic. Objective To determine geographic accessibility SARS-CoV-2 sites in United States, as quantified by travel time. Design Cross-sectional analysis of April 7, 2020 relation Setting States Participants The including 48 contiguous states and District Columbia. Exposures Population density, percent minority, uninsured, median income county from 2018 American Community Survey demographic data. Main Outcome...

10.1101/2020.04.25.20074419 preprint EN cc-by medRxiv (Cold Spring Harbor Laboratory) 2020-04-30

Abstract Background Recovery from alcohol use disorders (AUDs) consists of salutary changes in behavior and affect. While evidence suggests that recovery‐related behavioral changes, such as abstinence, emerge tandem with both neural affective the precise relationships among these are unknown. To understand relationships, we examined associations between duration abstinence (DOA), states, neuroimaging‐based structural measures brain reward system (BRS) AUD men (AUD M ) women W ). Methods...

10.1111/acer.14658 article EN Alcoholism Clinical and Experimental Research 2021-08-01

Abstract Tuberculosis (TB) remains a leading infectious disease killer globally. Treatment outcomes are especially poor among people with extensively drug-resistant (XDR) TB, until recently defined as rifampicin-resistant (RR) TB resistance to an aminoglycoside (amikacin) and fluoroquinolone (ofloxacin). We used laboratory test results from Western Cape province, South Africa between 2012 2015 identify XDR-TB pre-XDR-TB (RR-TB one second-line drug) spatial hotspots. mapped the percentage...

10.1038/s41598-022-14581-4 article EN cc-by Scientific Reports 2022-06-27

Countries around the world have implemented restrictions on mobility, especially cross-border travel to reduce or prevent SARS-CoV-2 community transmission. Rapid antigen testing (Ag-RDT), with on-site administration and rapid turnaround time may provide a valuable screening measure ease while minimizing risk of local To maximize impact, we developed an optimal Ag-RDT algorithm for entry. Using previously mathematical model, determined daily number imported COVID-19 cases that would generate...

10.1371/journal.pgph.0000086 article EN cc-by PLOS Global Public Health 2022-05-16

Abstract Rare kidney diseases are not well characterised, despite making a significant contribution to the burden of disease globally. The National Registry Kidney Diseases (RaDaR) collects longitudinal and treatment-related data from people living with rare across UK, is largest registry in world. We present clinical demographics renal function 25,880 prevalent patients evaluate for any potential recruitment bias RaDaR. RaDaR has automatic linkage UK Renal (UKRR, which all receiving...

10.1101/2023.09.24.23296009 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-09-25

Despite expanded antiretroviral therapy (ART) eligibility in South Africa, many people diagnosed with HIV do not initiate ART promptly, yet understanding of the reasons is limited. Using data from an 8-month prospective cohort interview study women and men newly-diagnosed three public-sector primary care clinics eThekwini (Durban) region, 2010–2014, we examined if theoretically-relevant social-structural, social-cognitive, psychosocial, health status indicators were associated time to...

10.1371/journal.pone.0246744 article EN cc-by PLoS ONE 2021-02-19

Summary The Philippines confirmed local transmission of COVID-19 on 7 March 2020. We described the characteristics and epidemiological time-to-event distributions for laboratory-confirmed cases in Philippines. median age 8,212 was 46 years (IQR: 32-61), with 46.2% being female 68.8% living National Capital Region. Health care workers represented 24.7% all detected infections. Mean length hospitalization those who were discharged or died 16.00 days (95% CI: 15.48, 16.54) 7.27 6.59, 8.24)....

10.1101/2020.07.15.20154336 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2020-07-20

ABSTRACT Data from non-traditional data sources, such as social media, search engines, and remote sensing, have previously demonstrated utility for disease surveillance. Few studies, however, focused on countries in Africa, particularly during the SARS-CoV-2 pandemic. In this study, we use searches of COVID-19 symptoms, questions, at-home remedies submitted to Google model South assess how well forecast short-term trends. Our findings suggest that information seeking trends could guide...

10.1101/2020.11.04.20226092 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2020-11-06

ABSTRACTABSTRACTObjective To test the hypothesis that a history of traumatic brain injury (TBI) prior to collegiate pre-season is associated with risk for re-injury. We also investigate sex differences, cognitive functioning, and self-reported concussion symptoms their associations risk.Methods A longitudinal cohort study consisting athletes (n = 212) who completed consecutive preseason evaluations (P1 P2) between 2012 2015, averaging 12.9 (SD 4.2) months apart.Results There were 40 new...

10.1080/02699052.2023.2203521 article EN Brain Injury 2023-04-19
Coming Soon ...