A5072066406- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Parkinson's Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Genetic Neurodegenerative Diseases
- Inflammation biomarkers and pathways
- Adipose Tissue and Metabolism
- Neurological disorders and treatments
- RNA Interference and Gene Delivery
- Medicinal Plants and Neuroprotection
- Adipokines, Inflammation, and Metabolic Diseases
Beijing Shijitan Hospital
2021-2025
Capital Medical University
2020-2025
Baoding People's Hospital
2020
Tetrahydroxy stilbene glycoside (TSG), which is the primary active substance of Chinese herbal medicine called Polygonum multiflorum, has been acknowledged to alleviate Alzheimer's disease (AD)-induced learning disorder in transgene mice. Because microglia activation really important during AD progression, herein, we determined effects TSG on neuropathology, polarization and its underlying mechanism. We used APP/PS1 mice along with immunohistochemistry immunofluorescence techniques evaluate...
Diagnosis of multiple system atrophy (MSA) remains a challenge, due to the complexity and overlapping its symptoms with other Parkinsonian disorders. The critical role alpha-synuclein ( α -syn) in pathogenesis MSA makes it an ideal biomarker for diagnosis MSA. Although -syn alterations cerebrospinal fluid (CSF) blood plasma have been extensively assessed utility diagnosing MSA, inconsistent results obtained, presumably contamination by hemolysis confounding factors. In this study, levels...
Abstract MicroRNAs (miRs) have been extensively studied for their involvement in multiple sclerosis (MS). We investigated the of miR‐134‐3p on MS. The MS rat model was established, and positive expression interleukin‐17 (IL‐17) detected using immunohistochemical method while serine protease 57 (PRSS57) determined by means reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) Western blot analysis. Second, overexpression or short hairpin RNA against PRSS57 introduced into...