A5014626717- Rheumatoid Arthritis Research and Therapies
- Inflammasome and immune disorders
- Medicinal Plants and Neuroprotection
- Neuroinflammation and Neurodegeneration Mechanisms
- Mycobacterium research and diagnosis
- Pharmacological Effects of Natural Compounds
- Inflammation biomarkers and pathways
- Systemic Lupus Erythematosus Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Tetrahydroxy stilbene glycoside (TSG), which is the primary active substance of Chinese herbal medicine called Polygonum multiflorum, has been acknowledged to alleviate Alzheimer's disease (AD)-induced learning disorder in transgene mice. Because microglia activation really important during AD progression, herein, we determined effects TSG on neuropathology, polarization and its underlying mechanism. We used APP/PS1 mice along with immunohistochemistry immunofluorescence techniques evaluate...
Objective: To investigate the mechanism of Simiao Yong’an Decoction in alleviating damage rheumatoid arthritis (RA), and accordingly provide pharmacological evidence further experimental support for application Decoction, as well a reference direction development new drugs RA treatments. Materials methods: Arthritis was induced Balb/c mice. The animals were randomly divided into 4 groups: control, model, methotrexate (MTX), group (n = 6). orally administered 4.5 g·kg −1 every day, MTX...