A5061665398- Cutaneous Melanoma Detection and Management
- Pancreatic and Hepatic Oncology Research
- Nonmelanoma Skin Cancer Studies
- Gastric Cancer Management and Outcomes
- Melanoma and MAPK Pathways
- Cutaneous lymphoproliferative disorders research
- COVID-19 and healthcare impacts
- Gallbladder and Bile Duct Disorders
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Pancreatitis Pathology and Treatment
- Immunotherapy and Immune Responses
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal Cancer Research and Treatment
- Polyomavirus and related diseases
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Thyroid and Parathyroid Surgery
- CAR-T cell therapy research
- Reconstructive Facial Surgery Techniques
- Airway Management and Intubation Techniques
University of California, Irvine
2008-2025
University of California, Irvine Medical Center
2007-2024
Symbiosis International University
2018
Symbiosis Group
2018
Moffitt Cancer Center
2013-2016
Penn State Milton S. Hershey Medical Center
2015
Zero to Three
2015
City Of Hope National Medical Center
2010
Toho University
2005
ABSTRACT Background Although most patients with cutaneous melanoma (CM) will have a negative sentinel lymph node biopsy (SLNB), up to 20%–30% of these recur. The 31‐gene expression profile (31‐GEP) test has been prospectively validated identify at low (Class 1A), intermediate 1B/2A), and high 2B) risk SLN positivity recurrence. Methods DECIDE is prospective, multicenter study assess the effect 31‐GEP testing on SLNB performance rates in T1–T2 tumors considering long‐term outcomes. Here, we...
The clinical value and prognostic implications of histologic response to neoadjuvant chemotherapy in gastric cancer is unknown.Tumor regression grade (TRG) was recorded 58 patients identified from two institutional surgical databases. TRG 1a/b represented responders (<10% viable tumor), while 2/3 non-responders (>10% tumor).TRG 10 (17%), 48 (83%) had a response. Larger tumor size (OR 0.24; 95%CI 0.09, 0.64; P = 0.004) downstaging 30.0; 3.26, 276; 0.003) were the only factors predictive...
<h3>Objective</h3> To investigate the use of Seamguard, a bioabsorbable staple line–reinforcement product, to prevent pancreatic leak after distal pancreatectomy. <h3>Design, Setting, and Participants</h3> A retrospective study examined 85 consecutive patients undergoing pancreatectomy at an academic institution from September 5, 1997, 30, 2007. <h3>Main Outcome Measures</h3> Pancreatic fistula overall mortality morbidity. <h3>Results</h3> In February 2004, Seamguard in pancreas resections...
Sentinel lymph node biopsy (SLNB) is indicated for the staging of clinically node-negative melanoma intermediate thickness, but its use controversial in patients with thick melanoma.From 2002 to 2012, measuring ≥4 mm thickness were evaluated at a single institution. Associations between survival and clinicopathologic characteristics explored.Of 571 melanomas no distant metastases, median age was 66 years 401 (70.2%) male. The Breslow 6.2 mm; predominant subtype nodular (45.4%). SLNB...
Background The 31-gene expression profile test (Class 1A: low-risk; 1B/2A: intermediate-risk; 2B: high-risk) is validated to identify patients with cutaneous melanoma who can safely forego sentinel lymph node biopsy (SLNB). objective of the current study quantify SLNB reduction by clinicians using 31-GEP.Methods Patients T1-T2 tumors eligible for were seen surgical oncologists (89.1%), dermatologists (7.8%), and medical (3.1%). After receiving 31-GEP results but before SLNB, asked which...
Abstract Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with steadily increasing incidence and poor prognosis. Despite recent success immunotherapy, 50% of patients still succumb to their diseases. To date, there no Food Drug Administration-approved targeted therapy for advanced MCC. Aberrant activation phosphatidylinositide-3-kinase (PI3K)/AKT/mTOR pathway frequently detected in MCC, making it an attractive therapeutic target. We previously found PI3K human...
This phase II study evaluated the safety and clinical activity of pazopanib, a potent mutlitargeted tyrosine kinase inhibitor (TKI) vascular endothelial growth factor receptors (VEGFRs)-1, -2 -3, platelet-derived receptor (PDGFR)-α β, cKit, in combination with metronomic paclitaxel patients metastatic melanoma. Sixty chemotherapy-naive received pazopanib at starting dose 800 mg daily dosing 80 mg/m2 weekly thrice every 4 weeks. The primary endpoint was 6-month progression-free survival (PFS)...
<h3>Background</h3> Checkpoint inhibitors have shown improvement in recurrence-free survival the post-operative setting for node-positive melanoma and were first approved late 2015. However, single-agent checkpoint therapies yet to show benefit overall (OS) lower-risk stage III cancers. We evaluated OS of immunotherapy National Cancer Database (NCDB). <h3>Patients methods</h3> Patient cases selected from NCDB 2020 Participant Use File. Patients diagnosed with cutaneous between 2016 2019 who...
The delivery of cancer care has never changed as rapidly and dramatically we have seen with the coronavirus disease 2019 (COVID-19) pandemic. During early phase pandemic, recommendations for management oncology patients issued by various professional societies government agencies did not recognize significant regional differences in impact California initially experienced lower than expected numbers cases, health system experience same degree burden that had been case other parts country. In...
Because the islets of Langerhans are more prevalent in body and tail pancreas, distal pancreatectomy (DP) is believed to increase likelihood developing new onset diabetes mellitus (NODM). To determine whether development postoperative was patients undergoing DP or Whipple procedure, 472 either a (n = 122) 350), regardless underlying pathology, were analyzed at one month postoperatively. Insulin oral hypoglycemic requirements assessed stratified into preoperative diabetic status: NODM...
With the increasing usage of neoadjuvant chemotherapy (NAC) in locally advanced breast cancer (LABC), there is need to investigate routine axillary node dissections performed this group patients. Controversy exists about utility sentinel biopsy (SNB), either before or after NAC. addition trastuzumab treatment Her2/neu-positive LABC patients, validity SNB subset population needs be investigated. A retrospective study 20 patients who underwent NAC for was undertaken. The pathology nodes, and...
Because PD continues to be a high-risk procedure, the overall 30-day readmission rate is approximately 15-25%.[6][7][8][9].Readmission rates of up 38% have been reported during 90 day peri-operative period [10].Previous studies