A5000258830- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Molecular Sensors and Ion Detection
- Mass Spectrometry Techniques and Applications
- DNA and Nucleic Acid Chemistry
- Chemical Reaction Mechanisms
- Molecular Communication and Nanonetworks
Freie Universität Berlin
2017-2018
Microbial rhodopsins are well known as versatile and ubiquitous light-driven ion transporters photosensors. While the proton transport mechanism has been studied in great detail, much less is about various modes of anion transport. Until recently, only two main groups pumps were known, archaeal halorhodopsins (HRs) bacterial chloride (known ClRs or NTQs). Last year, another group cyanobacterial with a very distinct primary structure was reported. Here, we chloride-transporting photocycle...
Channelrhodopsins (ChRs) are light-gated cation channels. In spite of their wide use to activate neurons with light, the photocurrents ChRs rapidly decay in intensity under both continuous illumination and fast trains light pulses, broadly referred as desensitization. This undesirable phenomenon has been explained by two interconnected photocycles, each them containing a nonconductive dark state (D1 D2) conductive (O1 O2). While D1 O1 states correspond dark-state P3520 intermediate primary...