A5084319446- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Diabetes and associated disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Carbohydrate Chemistry and Synthesis
- Blood groups and transfusion
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Musculoskeletal pain and rehabilitation
- Protease and Inhibitor Mechanisms
- Respiratory and Cough-Related Research
- Pancreatic function and diabetes
- Pneumonia and Respiratory Infections
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Microbial Metabolites in Food Biotechnology
- Blood properties and coagulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Proteoglycans and glycosaminoglycans research
- Machine Learning in Bioinformatics
- Acute Myocardial Infarction Research
- Tuberculosis Research and Epidemiology
- RNA modifications and cancer
University of Rijeka
2022-2025
Science Research Laboratory
2015-2024
Genos (Croatia)
2015-2024
University of Split
2011-2023
Yale University
2020-2023
University of New Haven
2023
King's College London
2018
Heinrich Heine University Düsseldorf
2017
Deutsches Diabetes-Zentrum e.V.
2017
German Center for Diabetes Research
2017
Objective Glycans attached to the Fc portion of IgG are important modulators effector functions. Interindividual differences in glycome composition large and they associate strongly with different inflammatory autoimmune diseases. IKZF1 , HLA–DQ2A/B BACH2 genetic loci that affect show pleiotropy systemic lupus erythematosus (SLE), indicating a potentially causative role aberrant glycosylation SLE. We undertook this multicenter case–control study determine whether SLE is associated altered...
The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To investigate potential cellular diversity, we profiled single-nucleus transcriptomes five subregions humans, macaques, pigs. Integrated cross-species analysis revealed robust transcriptomic histologic signatures of neurogenesis the adult mouse, pig, macaque but not humans. Doublecortin (DCX), a widely accepted marker...
Effector functions of immunoglobulin G (IgG) are regulated by the composition a glycan moiety, thus affecting activity immune system. Aberrant glycosylation IgG has been observed in many diseases, but little is understood about underlying mechanisms. We performed genome-wide association study N-glycosylation (
One measure of protein glycosylation (GlycA) has been reported to predict higher cardiovascular risk by reflecting inflammatory pathways.The main objective this study is assess the role a comprehensive panel IgG traits on traditional factors for disease and presence subclinical atherosclerosis in addition GlycA.We measured 76 2970 women (age range, 40-79 years) from TwinsUK cohort correlated it their estimated 10-year atherosclerotic score carotid femoral plaque ultrasound imaging. Eight...
Posttranslational glycosylation of IgG can modulate its inflammatory capacity through structural variations. We examined the association baseline N-glycans and an glycan score with incident cardiovascular disease (CVD).
Antibodies are known to have an important role in the development of rheumatoid arthritis (RA), one most prevalent chronic inflammatory diseases which primarily involves joints. Most RA patients develop autoantibodies against immunoglobulin G (IgG) and changes IgG glycosylation been associated with RA. We undertook this study determine whether altered precedes disease diagnosis. studied two prospective cohorts (N = 14,749) by measuring 28 glycan traits 179 subjects who developed within...
Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through attachment of various sugar moieties called glycans. Composition IgG N-glycome changes with age an individual in different diseases. Variability glycosylation within a population well studied known to be affected by both genetic environmental factors. However, global inter-population differences have never been properly addressed. Here we present...
Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted hospitals Europe and China. In addition, we evaluated progress symptoms 37,187 individuals reporting into COVID Symptom Study application. Findings: Meta-analysis mortality risk seven European estimated odds ratios per 1-day increase admission date 0.981 (0.973–0.988, p < 0.001)...
Coronary artery disease (CAD) is the most common cardiovascular (CVD), and previous studies have shown a significant association between N-glycosylation, highly regulated posttranslational modification, development of atherosclerotic plaques. Our aim was to determine whether N-glycome immunoglobulin G (IgG) associated with CAD, as N-glycans are known alter effector functions IgG, which may enhance inflammatory response in CAD. Therefore, this study, we isolated IgG from subjects coronary...
Exercise and exercise-induced weight loss have a beneficial effect on overall health, including positive effects molecular pathways associated with immune function, especially in overweight individuals. However, prolonged intense exercise training periods without sufficient recovery energy intake aiming to accomplish very low levels of body fat may lead temporary immunodepression. Here, we applied high-throughput systems biology approach better characterize potential key system modulation...
Atrial fibrillation is a disease with complex pathophysiology, whose occurrence and persistence are caused not only by aberrant electrical signaling in the heart, but development of susceptible heart substrate. These changes, such as accumulation adipose tissue interstitial fibrosis, characterized presence inflammation. N-glycans have shown great promise biomarkers different diseases, specifically those involving inflammatory changes. To assess changes N-glycosylation plasma proteins IgG...
Glycosylation is one of the most common post-translation modifications with large influences on protein structure and function. The effector function immunoglobulin G (IgG) alters between pro- anti-inflammatory, based its glycosylation. IgG glycan synthesis highly complex dynamic.With use two different analytical methods for assessing glycosylation, we aim to elucidate link DNA methylation glycosylation by means epigenome-wide association studies. In total, 3000 individuals from 4 cohorts...
Increasing evidence implicates lysosomal dysfunction in the pathogenesis of neurodegenerative diseases, including rare inherited storage disorders (LSDs) and most common such as Alzheimer's Parkinson's disease (AD PD). Although triggers impairment may involve accumulated macromolecules or enzymes, role glycocalyx (dys)function has not been studied. The goal this work was to analyze whether there are changes a cellular model LSD Niemann-Pick type C (NPC). Using ferrofluid nanoparticles we...
Aim: The study sought to apply N-glycosylation profiles understand the interplay between suboptimal health status (SHS) and metabolic syndrome (MetS). Materials & methods: In this study, 262 Ghanaians were recruited from May July 2016. After completing a survey, plasma samples collected for clinical assessments while ultra performance liquid chromatography was used measure N-glycans. Results: Four glycan peaks found predict case (MetS SHS) using step-wise Akaike's information criterion...
Comparative "omics" studies have revealed unique aspects of human neurobiology, yet an evolutionary perspective the brain N-glycome is lacking. We performed multiregional characterization rat, macaque, chimpanzee, and N-glycomes using chromatography mass spectrometry then integrated these data with complementary glycotranscriptomic data. found that, in primates, has diverged more rapidly than underlying transcriptomic framework, providing a means for generating additional interspecies...
Abstract Low back pain (LBP) is a common debilitating condition which aetiology and pathogenesis are poorly understood. We carried out first so far analysis of associations between LBP plasma IgG N-glycome in sample 4511 twins from TwinsUK database assessed for LBP, lumbar disc degeneration (LDD) as its possible cause, IgG-glycan levels. Using weighted correlation network analysis, we established glycan modules featured by glycans that either promote or block antibody-dependent cell-mediated...
Abstract Systemic inflammation participates to the complex healing process occurring after major surgery, thus directly affecting surgical outcome and patient recovery. Total plasma N-glycome might be an indicator of as well anti-inflammatory therapy response marker, since protein glycosylation plays essential role in inflammatory cascade. Therefore, we assessed effects surgery on total association with self-administration postoperative morphine two cohorts patients that underwent abdominal...
Obesity-induced inflammation activates the adaptive immune system by altering immunoglobulin G (IgG) glycosylation in a way to produce more proinflammatory antibodies. The IgG glycome has already been well studied, and its alterations are correlated with high body mass index (BMI) central adiposity. Still, N-glycome susceptibility different dietary regimes for weight control after initial loss not studied. To explore changes induced subsequent weight-maintenance diets, we analyzed 1,850...