A5051053824- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Neuroblastoma Research and Treatments
- Melanoma and MAPK Pathways
- Nail Diseases and Treatments
- RNA Research and Splicing
- Hepatitis B Virus Studies
- Biomarkers in Disease Mechanisms
- PARP inhibition in cancer therapy
- Ocular Oncology and Treatments
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- Urinary and Genital Oncology Studies
- Neuroendocrine Tumor Research Advances
- Circular RNAs in diseases
- Bone Tumor Diagnosis and Treatments
- Male Breast Health Studies
- Genital Health and Disease
- Urological Disorders and Treatments
- Lung Cancer Research Studies
- Cancer and Skin Lesions
- Skin Protection and Aging
Nicolaus Copernicus University
2017-2021
Collegium Medicum in Bydgoszcz
2017-2021
Available biomarkers for pancreatic adenocarcinoma (PAC) are inadequate to guide individual patient prognosis or therapy. Therefore, herein we aimed verify the hypothesis that differences in expression of KIF11 and KIF14, i.e., molecular motor proteins being primarily implicated cell division events could account clinical outcome PAC patients. In-house immunohistochemistry was used evaluate protein expressions KIF14 PAC, whereas RNA-seq datasets providing transcript data were obtained from...
The existence, the functional role and clinical relevance of GDF15 its signaling through a GFRAL/RET-dependent complex in gastric cancer (GC) other human tumors remain to be elucidated, despite widespread recognition obesity as an important cancer-predisposing factor.Therefore, we aimed analyze expression levels GDF15, GFRAL RET GC tissues relation each clinicopathological features, including patient survival, order establish potential implication body-weight pathway pathology outcome...
Prostate cancer (PCa) is the second most commonly diagnosed malignant tumor and fifth leading cause of death in men world. The common types tumors are adenocarcinomas. a slow-growing cancer. incidence increases with age. Evaluation proinflammatory factors such as IL-17A, IL-17F, IL-17RA, IL-17RC expression makes it possible to assess impact inflammatory process on progression PCa. aim study was retrospectively histological material PCa divided into few groups using Gleason score. Studies...
Gastric cancer (GC) is currently recognized as one of the most common and fatal tumor worldwide. The identification novel biomarkers in relation to clinical information well extending knowledge on a multiple crosstalk between various oncogenic pathways implicated GC carcinogenesis seems pivotal limit disease-associated mortality. Therefore, we assessed expression HER2, NF- κ B, SATB1 total 104 gastric adenocarcinomas 30 normal samples correlated patterns with each other some...
The BRAF V600E mutation is an important oncological target in certain central nervous system (CNS) tumors, for which a possible application of BRAF-targeted therapy grows continuously. In the present study, we aim to determine prevalence mutations series ganglioglioma (GG) and pilocytic astrocytoma (PA) cases. Simultaneously, decided verify whether combination fully automated tests—BRAF-VE1 immunohistochemistry (IHC) Idylla assay—may be useful accurately predict it case specified CNS tumors....
<B>Purpose</B>: Disseminated malignancies are a diagnostic and therapeutic challenge that is often encountered in radiology. Finding the primary tumour crucial for planning proper surgical oncological treatment. Computed tomography (CT) of thorax abdomen typically initial examination. However, abdominal magnetic resonance imaging (MRI) or positron emission (PET/CT) PET/MRI subsequently performed. Histopathological examination metastatic tumours performed as well, followed by...
Chondrosarcoma is a malignant mesenchymal tumour that the second most common bone after osteosarcoma. Its diagnosis among difficult ones in pathology. Here, we report very unique case of chondrosarcoma maxillary sinus. A 45-year-old woman presented with on left side sinus. CT and MRI imaging showed an abnormal mass destructing surrounding tissues. The final could not be made for long time due to lack correlation between clinical microscopic examinations. patient underwent left subtotal...
The purpose of this research was to explore the correlation between Gleason score and pattern expression MLH1, MSH2, MDC1, TP53BP1 proteins in prostate cancer (PC). Prostate development is related errors DNA, among others double-strand breaks (DSB) changes base sequence DNA. These should be repaired through mismatch (MMR) or DSB repair such as MDC1 TP53BP1.A total 500 specimens were recruited study. From all gathered 52 most suitable cases selected. examined detected by immunohistochemistry,...
Desmoplasia is crucial for the development, progression and treatment of immune-resistant malignancies. Targeting desmoplasia-related metabolic pathways appears to be an interesting approach expand our stock disposable anti-tumor agents. CXCL12/CXCR4 axis inhibition reduces fibrosis, alleviates immunosuppression significantly enhances efficacy PD-1 immunotherapy. CD40L substitute therapy may increase activity T-cells, downregulate CD40+, prolong patients' survival prevent cancer progression....