A5067735057- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Retinoids in leukemia and cellular processes
- Tissue Engineering and Regenerative Medicine
- Cell death mechanisms and regulation
- Cutaneous lymphoproliferative disorders research
- RNA Interference and Gene Delivery
- DNA Repair Mechanisms
- Autophagy in Disease and Therapy
- Radiopharmaceutical Chemistry and Applications
- Urological Disorders and Treatments
- Cell Adhesion Molecules Research
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Acute Myeloid Leukemia Research
- Heat shock proteins research
- Mesenchymal stem cell research
- Cancer Treatment and Pharmacology
- Cancer therapeutics and mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- Nuclear Structure and Function
- Genomics, phytochemicals, and oxidative stress
Collegium Medicum in Bydgoszcz
2016-2025
Nicolaus Copernicus University
2016-2025
University of Bydgoszcz
1991-2015
Poznan University of Medical Sciences
2010
Kazimierz Wielki University in Bydgoszcz
2001-2003
Pedagogical University
2000
Institute of Molecular Pathology and Pathomorphology
1991
The use of the dietary polyphenols as chemosensitizing agents to enhance efficacy conventional cytostatic drugs has recently gained attention scientists and clinicians a plausible approach for overcoming limitations chemotherapy (e.g. drug resistance cytotoxicity). aim this study was investigate whether naturally occurring diet-based flavonoid, fisetin, at physiologically attainable concentrations, could act synergistically with clinically achievable doses paclitaxel produce growth...
Lung cancer is one of the most common tumors and its treatment still inefficient. In our previous work we proved that ciprofloxacin has a different influence on five cell lines. Here, aimed to compare biological effect lines representing responses after treatment, thus A549 was chosen as sensitive model, C6 B16 highly resistant. Three were analyzed (A549, C6). The characterization continuous growth with Real-Time Cell Analyzer (RTCA)-DP system. Cytoskeletal changes demonstrated using...
Senescence in the population of cells is often described as a program restricted proliferative capacity, which manifested by broad morphological and biochemical changes including metabolic shift towards an autophagic-like response genotoxic-stress related induction polyploidy. Concomitantly, cell cycle progression senescent believed to be irreversibly arrested. Recent reports suggest that this phenomenon may have influence on therapeutic outcome anticancer treatment. The aim study was verify...
Lamins are the major components of nuclear lamina and play important roles in many cellular processes. The role lamins cancer development progression is still unclear but it known that reduced expression lamin B1 has been observed colon cancer. Thus, aim present study was to elucidate influence LMNB1 upregulation on cell line after treatment with 5-FU. results indicate, overexpression induced dose-dependent death mainly by mitotic catastrophe pathway. Furthermore, this intermediate protein,...
Metastasis is one of the most urgent issues in breast cancer patients. One factors necessary migration process remodeling extracellular matrix (ECM). Metalloproteinases (MMPs) can break down elements ECM, which facilitates cell movement. Many highly aggressive tumors are characterized by high levels MMPs. In case cancer, association between MMP-9 and potential invasiveness cells has been demonstrated. addition, reports indicating increased after administration commonly used cytostatic...
The identification and development of new agents with a therapeutic potential as well novel drug combinations are gaining the attention scientists clinicians plausible approach to improve regimens for chemoresistant tumors. We have recently reported that flavonoid fisetin (FIS), at physiologically attainable concentrations, acts synergistically clinically achievable doses paclitaxel (PTX) produce growth inhibitory pro-death effects on A549 human non-small cell lung cancer (NSCLC) cells. To...
In the present study, we aimed to assess selected components of cell cycle machinery, checkpoint, DNA repair, and synthesis, namely RRM2, cyclin F, SPDL1 in pancreatic adenocarcinomas (PAC) by in-house immunohistochemistry (IHC) bioinformatic analysis public datasets, terms expression, correlation with clinicopathological parameters, patient survival. Sixty eight patients ductal adenocarcinoma (PDAC) were included our cohort IHC was performed on tissue macroarrays. RNA-Seq-based...
Tumor necrosis factor α (TNFα) is one of the most important proinflammatory cytokines, which affects many processes associated with growth and characteristics endothelial, smooth muscle, immune system cells. However, there no correlation between in vivo vitro studies on its role endothelial cell proliferation migration. In this study, we examined effect recombinant human (rh) TNFα produced HEK293 cells primary coronary artery (pHCAECs) context F-actin organization such as migration adhesion....
Abstract Jurkat human lymphoblastoid cells were incubated in increasing concentrations of doxorubicin (0.05, 0.1 and 0.15 μM) to induce cell death, their expression cyclin A, B1 D1 was evaluated by flow cytometry (cell cycle progression, Annexin V assay, percentages levels each the cyclins), transmission electron microscopy (ultrastructure) confocal fluorescence (expression intracellular localization cyclins). After low‐dose treatment, responded mainly G2/M arrest, which related increased...
A variety of tissue engineering techniques utilizing different cells and biomaterials are currently being explored to construct urinary bladder walls de novo, but so far no approach is clearly superior. The aim this study was determine whether mesenchymal stem (MSCs) isolated from sources, (bone marrow [BM-MSCs] adipose [ADSCs]), differ in their potential regenerate smooth muscles tissue-engineered bladders an optimal number MSCs for muscle regeneration. Forty-eight rats underwent...
Background: Cancers are one of the leading causes deaths nowadays. The development new treatment schemes for oncological diseases is an interesting direction in experimental medicine. Therefore, evaluation influence two alkaloids—piperlongumine (PL), sanguinarine (SAN) and their combination—on basic life processes A549 cell line was considered reasonable. Methods: aim achieved by analyzing cytotoxic effects PL SAN combination ratio 4:1 on induction death, changes distribution cycle phases,...
Available biomarkers for pancreatic adenocarcinoma (PAC) are inadequate to guide individual patient prognosis or therapy. Therefore, herein we aimed verify the hypothesis that differences in expression of KIF11 and KIF14, i.e., molecular motor proteins being primarily implicated cell division events could account clinical outcome PAC patients. In-house immunohistochemistry was used evaluate protein expressions KIF14 PAC, whereas RNA-seq datasets providing transcript data were obtained from...