A5023507402- Neutropenia and Cancer Infections
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Blood disorders and treatments
- Acute Lymphoblastic Leukemia research
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Renal and related cancers
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Neonatal Health and Biochemistry
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Transplantation Outcomes and Treatments
- Chemotherapy-induced organ toxicity mitigation
- Nutrition and Health in Aging
- Hematological disorders and diagnostics
- Potassium and Related Disorders
- Nausea and vomiting management
- Urological Disorders and Treatments
- Methemoglobinemia and Tumor Lysis Syndrome
- Renal cell carcinoma treatment
- Neuroblastoma Research and Treatments
Sapporo Hokuyu Hospital
2015-2024
Suzuki (Japan)
2020
Pediatrics and Genetics
2016
Infection, especially invasive fungal infection (IFI), is an important complication of chemotherapy and stem cell transplantation. It also a well-known risk factor in pediatric hematologic malignancy, acute myelogenous leukemia, recurrent disease allogeneic We previously revealed that diagnosis >10 years age were factors for IFI patients with malignancies. examined compared the incidence, mortality rate from between 276 2007 to 2016 our past report. The cumulative incidence was 10.5%; this...
Introduction Children and adolescents with mature B cell non-Hodgkin lymphoma (B-NHL) are treated short-intensive chemotherapy. The burden of short-term long-term toxicity is highly relative to its high cure rate in good-risk patients. Although the addition rituximab standard lymphome Malin (LMB) chemotherapy markedly prolongs event-free survival overall high-risk patients, benefit patients remains be elucidated. This clinical trial will examine whether eliminates anthracyclines without...
Abstract Background This randomized prospective study was designed to assess whether piperacillin/tazobactam (PIPC/TAZ) is as effective meropenem (MEPM) a first‐line antibiotic treatment for febrile neutropenia (FN). Procedure FN episodes were randomly assigned receive either PIPC/TAZ (337.5 mg/kg per day in three doses, 1‐hr DIV, maximum 13.5 g day) or MEPM (120 3 day). Clinical responses evaluated 120 hr after the DIV. Results A total of 434 105 patients (42 females and 63 males) with...
Abstract Background Mucormycosis is one of the most refractory invasive fungal infections and often causes fatal infection in immunocompromised patients, such as those with severe diabetes mellitus hematologic malignancies. Methods We retrospectively evaluated efficacy stem cell transplantation for a pediatric patient acute myeloid leukemia (AML) who developed mucormycosis. Results An 8‐year‐old boy received chemotherapy, but relapsed 3 months after discontinuation treatment. Subsequent...
Pediatric patients under treatment for acute myeloid leukemia (AML) are at high risk invasive fungal infection (IFI). We evaluated the efficacy of prophylactic administration voriconazole (VRCZ) with two different doses.Between October 2005 and June 2011, 17 children adolescents (aged 0-20 years) undergoing chemotherapy AML were prophylactically administered 5 mg/kg/d oral VRCZ. Furthermore, 22 0-19 10 VRCZ between July 2011 December 2014. The incidences IFI doses compared.Irrespective...
Abstract Background Urolithiasis is an extremely rare complication in childhood acute lymphoblastic leukemia (ALL), and some reports have implicated corticosteroids during chemotherapy as a risk factor for it. However, only few analyzed urinary electrolytes this context. Methods We retrospectively 55 patients with ALL who underwent between October 2007 January 2019. Their median age was 9.3 years (range, 0.3–24.0 years) 30 males 25 females. Lineages were B‐cell precursor (BCP‐ALL) 42...
The aim of the present study was to determine if febuxostat could prevent tumor lysis syndrome (TLS) in children who received induction chemotherapy for hematologic malignancies.A retrospective analysis performed 45 pediatric patients with hematological malignancies (10 mg daily, n=20) or allopurinol (300 mg/m2 n=25) as a prophylaxis TLS.A significant decrease serum uric acid (UA) level observed over first 2 days (6.6±3.8 mg/dl vs. 4.5±2.8 mg/dl, p<0.001). group also showed reduction urinary...
Background: Long-term venous access is essential when treating malignant diseases. As an alternative to conventional central catheters, peripherally inserted catheter (PICC) are now widely used. The aim of this study evaluate the safety, efficacy, and reliability PICCs in comparison with previous reports, describe significant complications associated their use. Patients Methods: From June 2009 November 2017, were 258 times a total 160 pediatric young adult patients at our institution. We...
Extrarenal nephroblastoma (ERNB) is a rare disease. We report case of ERNB in 4-year-old boy complaining abdominal pain and vomiting. Imaging showed retroperitoneal mass left hydronephrosis. The was completely removed by surgery. pathologic diagnosis with favorable histology. Postoperative chemotherapy administered for 24 weeks actinomycin D, vincristine, doxorubicin. No signs recurrence were found the next 3 years. consider 53 reports our own. Median age at 42 months. most common site space...
Abstract Background Stem cell transplantation (SCT) outcomes have improved over the last three decades, with many patients being rescued this treatment. However, led to issues long‐term sequelae. One of these sequelae in children is renal dysfunction, an index which estimated using glomerular filtration rate (eGFR). Procedure We retrospectively analyzed eGFR 83 pediatric who received SCT. Data from all extended up 12 months or more post The median follow‐up time was 127.7 (range 12.0‐268.8...
Antibiotics have been widely and efficaciously used for febrile neutropenia in pediatric patients. However, reports are scant regarding the risk factors recurrent fever after discontinuation of antibiotics a neutropenic state. Here, we investigated these using data from our previously reported randomized study meropenem piperacillin/tazobactam patients with neutropenia.We analyzed total 170 episodes where first line antibiotic treatment was effective discontinued before neutrophil...
Although survival of children with hematological diseases and cancer has increased dramatically, life-threatening complications due to bacterial infections occur in 5–10% febrile episodes pediatric patients. A prospective randomized study was performed clarify the usefulness meropenem (MEPM) piperacillin/tazobactam (PIPC/TAZ) or without intravenous immunoglobulin (IVIG) as second-line therapy for patients neutropenia (FN). As first-line FN, 105 434 were randomly assigned receive MEPM...
Liposomal amphotericin (L-AMB) is a widely used broad-spectrum antifungal drug. Although L-AMB demonstrates better safety compared with amphotericin, renal dysfunction and hypokalemia are well-known adverse effects of L-AMB.We analyzed 56 episodes in 40 children adolescents who received therapy to determine risk factors hypokalemia.Hypokalemia (<3.0 mEq/L continuously for more than 2 episodes) was observed 31 (55.4%). The median onset at 10 days on (range, 3-54 days), the cumulative dose...
Adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) are more likely to have chemotherapy-related complications than children. In addition, several reports shown that infections account for most of the therapy-related mortality during cancer treatment in AYAs. Thus, we hypothesized chemotherapy-induced myelosuppression is severe AYAs children, state neutropenia was compared between children using D-index, a numerical value calculated from duration depth...
Abstract Peripheral T‐cell lymphoma (PTCL) is rare in children, and it has a poor prognosis compared with other types of lymphoma. We report the case 7‐year‐old boy spontaneous improvement PTCL complicated by hemophagocytic syndrome as initial symptom. He complained pain swelling right neck presented high fever. Pancytopenia, liver dysfunction, elevated ferritin soluble interleukin 2 receptor were noted on laboratory tests. blood plasma white cells positive for Epstein–Barr virus (EBV)...
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