A5065718227- Bat Biology and Ecology Studies
- Viral Infections and Vectors
- interferon and immune responses
- Environmental and Biological Research in Conflict Zones
- Physiological and biochemical adaptations
- Immune responses and vaccinations
- Immune Response and Inflammation
- Viral Infections and Outbreaks Research
- Animal Vocal Communication and Behavior
- Marine animal studies overview
- Mosquito-borne diseases and control
Tel Aviv University
2022-2025
Zoonoses are infectious diseases transmitted from animals to humans. Bats have been suggested harbour more zoonotic viruses than any other mammalian order1. Infections in bats largely asymptomatic2,3, indicating limited tissue-damaging inflammation and immunopathology. To investigate the genomic basis of disease resistance, Bat1K project generated reference-quality genomes ten bat species, including potential viral reservoirs. Here we describe a systematic analysis covering 115 that revealed...
Abstract Bats have adapted to pathogens through diverse mechanisms, including increased resistance – rapid pathogen elimination, and tolerance limiting tissue damage following infection. In the Egyptian fruit bat (an important model in comparative immunology) several mechanisms conferring disease were discovered, but underpinning remain poorly understood. Previous studies on other species suggested that elevated basal expression of innate immune genes may lead Here, we test whether such...
Abstract Bats carry viruses that can cause severe disease in other mammals. Asymptomatic infections bats suggest limited tissue-damaging inflammation and immunopathology. To investigate the genomic basis of resistance, Bat1K project generated reference-quality genomes ten bat species. A systematic analysis showed signatures selection immune genes are more prevalent compared with We found an excess gene adaptations ancestral Chiroptera many descending lineages, highlighting viral entry...
Bats host a range of disease-causing viruses without displaying clinical symptoms. The mechanisms behind this are continuous source interest. Here, we studied the antiviral response in Egyptian fruit bat and Kuhl's pipistrelle, representing two subordinal clades. We profiled fibroblasts using RNA sequencing compared with primate rodent responses. Both bats upregulate similar genes; however, subset these genes is transcriptionally divergent between them. These also evolve rapidly sequence,...
Hearing loss is a hallmark of aging, typically initially affecting the higher frequencies. In echolocating bats, ability to discern high frequencies essential. However, nothing known about age-related hearing in and they are often assumed be immune it. We tested 47 wild Egyptian fruit bats by recording their auditory brainstem response cochlear microphonics, we also assessed histology four these bats. used bats' DNA methylation profile evaluate age found that exhibit loss, with more...
Abstract The Egyptian fruit bat displays tolerance to lethal viruses and unique dietary adaptations, but the molecular basis for this is poorly understood. To end, we generated detailed maps of gut, lung blood cells using spatial single-cell transcriptomics. We compared with mouse human reveal divergence in genetic programs associated environmental interactions immune responses. Complement system genes are transcriptionally divergent, uniquely expressed gut epithelium, undergo rapid...
Abstract Bats host a range of viruses that cause severe disease in humans without displaying clinical symptoms to these infections. The mechanisms bat adaptation are continuous source interest but remain largely unknown. To understand the landscape antiviral response comprehensive and comparative manner, we studied this two species - Egyptian fruit insectivore Kuhl’s pipistrelle, representing major subordinal clades. We profiled transcriptional dsRNA – triggers rapid innate immune skin...